Source Human Mouse Function Location Target Human Mouse Function Location Effects Type of interaction PubMedID GLYCINE NA NA Ligand Extracellular NMDAR Q12879 P35436 Receptor Membrane + Binding 7870047 GLYCINE NA NA Ligand Extracellular NMDAR Q12879 P35436 Receptor Membrane + Binding 12646920 GLYCINE NA NA Ligand Extracellular NMDAR Q12879 P35436 Receptor Membrane + Binding 2433595 CAMKII Q9UQM7 P11798 Kinase Cytosol SYNAPSIN P17600 O88935 Vesicle Vesicles _ Phosphorylation 7890745 CAMKII Q9UQM7 P11798 Kinase Cytosol SYNAPSIN P17600 O88935 Vesicle Vesicles _ Phosphorylation 9016342 CAMKII Q9UQM7 P11798 Kinase Cytosol MAP2 P11137 P20357 Cytoskeleton Cytosol + Phosphorylation 7890745 CAMKII Q9UQM7 P11798 Kinase Cytosol MAP2 P11137 P20357 Cytoskeleton Cytosol + Phosphorylation 9341200 GLYT1 P48067 P28571 Transporter Membrane GLYCINE NA NA Ligand Extracellular _ Importing 9861038 GLYT1 P48067 P28571 Transporter Membrane GLYCINE NA NA Ligand Extracellular _ Importing 8183239 GLYT1 P48067 P28571 Transporter Membrane GLYCINE NA NA Ligand Extracellular _ Importing 8494645 CAMKII Q9UQM7 P11798 Kinase Cytosol AMPAR P42261 P23818 Channel Membrane + Phosphorylation 9197267 CAMKII Q9UQM7 P11798 Kinase Cytosol AMPAR P42261 P23818 Channel Membrane + Phosphorylation 10077673 CALCIUM NA NA Messenger Cytosol CALMODULIN P62158 P62204 Activator Cytosol + Binding 7356670 CASPASE3 P42574 P70677 Protease Cytosol ICAD O00273 O54786 Inhibitor Cytosol _ Cleavage 9422513 ICAD O00273 O54786 Inhibitor Cytosol CAD O76075 O54788 DNase Nucleus _ Binding 9422513 CASPASE3 P42574 P70677 Protease Cytosol ICAD O00273 O54786 Inhibitor Cytosol _ Cleavage 12655299 ICAD O00273 O54786 Inhibitor Cytosol CAD O76075 O54788 DNase Nucleus _ Binding 12655299 PDK1 O15530 Q9Z2A0 Kinase Cytosol S6K P23443 Q9Z1M4 Kinase Cytosol + Phosphorylation 9427642 GLUTAMATE NA NA Ligand Extracellular AMPAR P42261 P23818 Channel Membrane + Binding 1311100 GIRK P48549 P35562 Channel Membrane POTASSIUM NA NA Ion Cytosol + Opening 8355805 PIP2 NA NA Lipid Cytosol GIRK P48549 P35562 Channel Membrane + Binding 10559906 GBETAGAMMA P11016 P11016 Gprotein Cytosol GIRK P48549 P35562 Channel Membrane + Binding 2433589 GBETAGAMMA P11016 P11016 Gprotein Cytosol GIRK P48549 P35562 Channel Membrane + Binding 8145826 SODIUM NA NA Ion Cytosol GIRK P48549 P35562 Channel Membrane + Binding 8804710 AMPAR P42261 P23818 Channel Membrane SODIUM NA NA Ion Cytosol + Opening 1380467 AMPAR P42261 P23818 Channel Membrane SODIUM NA NA Ion Cytosol + Opening 1652753 GABA NA NA Ligand Extracellular GABABR Q9UBS5 Q8K452 Receptor Membrane _ Binding 9069281 GABAAR P14867 P18504 Receptor Membrane GABARAP Q9BY60 P60518 Adapter Cytosol 0 Binding 9892355 GABAAR P14867 P18504 Receptor Membrane GABARAP Q9BY60 P60518 Adapter Cytosol 0 Binding 10984509 TUBULIN P05209 P05209 Cytoskeleton Cytosol GABARAP Q9BY60 P60518 Adapter Cytosol 0 Binding 9892355 TRKA P04629 Q9Z139 Receptor Membrane SHC P29353 Q61120 Adapter Cytosol + Binding 8552402 TRKA P04629 Q9Z139 Receptor Membrane SHC P29353 Q61120 Adapter Cytosol + Binding 8226808 TRKA P04629 Q9Z139 Receptor Membrane SHC P29353 Q61120 Adapter Cytosol + Binding 15056278 GABAAR P14867 P18504 Receptor Membrane GABARAP Q9BY60 P60518 Adapter Cytosol 0 Binding 11414770 GEPHYRIN Q9NQX3 Q8BUV3 Adapter Membrane GABARAP Q9BY60 P60518 Adapter Cytosol 0 Binding 10900017 GEPHYRIN Q9NQX3 Q8BUV3 Adapter Membrane TUBULIN P05209 P05209 Cytoskeleton Cytosol 0 Binding 1319186 CALMODULIN P62158 P62204 Activator Cytosol CAMKII Q9UQM7 P11798 Kinase Cytosol + Binding 3006921 TRKA P04629 Q9Z139 Receptor Membrane GRIT Q8IUG4 Q91V57 GAP Cytosol + Binding 12446789 TRKA P04629 Q9Z139 Receptor Membrane CRK P46108 Q64010 Adapter Cytosol + Binding 12446789 TRKA P04629 Q9Z139 Receptor Membrane CRK P46108 Q64010 Adapter Cytosol + Binding 8552402 CRK P46108 Q64010 Adapter Cytosol GRIT Q8IUG4 Q91V57 GAP Cytosol + Binding 12446789 JNK P45983 Q91Y86 Kinase Nucleus AP1 P05412 P05627 TF Nucleus + Phosphorylation 1608942 CASPASE9 P55211 Q9R0T0 Protease Cytosol CASPASE6 P55212 O08738 Protease Cytosol + Cleavage 9651578 CASPASE9 P55211 Q9R0T0 Protease Cytosol CASPASE6 P55212 O08738 Protease Cytosol + Cleavage 12097334 CASPASE9 P55211 Q9R0T0 Protease Cytosol CASPASE3 P42574 P70677 Protease Cytosol + Cleavage 9390557 CASPASE9 P55211 Q9R0T0 Protease Cytosol CASPASE7 P55210 P97864 Protease Cytosol + Cleavage 9651578 ATF2 P15336 Q60765 TF Nucleus AP1 P05412 P05627 TF Nucleus + Binding 2320002 ATF2 P15336 Q60765 TF Nucleus CRE NA NA DNA Nucleus + Binding 2320002 ATF2 P15336 Q60765 TF Nucleus TRE NA NA DNA Nucleus + Binding 2320002 VRK1 Q99986 Q80X41 Kinase Cytosol ATF2 P15336 Q60765 TF Nucleus + Phosphorylation 15105425 MGLUR1 Q13255 P97772 Receptor Membrane GBETAGAMMA P11016 P11016 Gprotein Cytosol + Binding 1847995 MGLUR1 Q13255 P97772 Receptor Membrane GALPHAQ P50148 P21279 Gprotein Cytosol + Binding 1847995 MGLUR5 Q13255 P97772 Receptor Membrane GBETAGAMMA P11016 P11016 Gprotein Cytosol + Binding 12351712 MGLUR5 Q13255 P97772 Receptor Membrane GBETAGAMMA P11016 P11016 Gprotein Cytosol + Binding 1320017 MGLUR5 Q13255 P97772 Receptor Membrane GALPHAQ P50148 P21279 Gprotein Cytosol + Binding 12351712 MGLUR5 Q13255 P97772 Receptor Membrane GALPHAQ P50148 P21279 Gprotein Cytosol + Binding 1320017 MGLUR5 Q13255 P97772 Receptor Membrane DYNAMIN Q05193 P09922 GTPase Vesicles 0 Binding 12646135 HOMER Q9NSB8 Q99JP6 Adapter Cytosol DYNAMIN Q05193 P09922 GTPase Vesicles 0 Binding 12646135 GLUTAMATE NA NA Ligand Extracellular NMDAR Q12879 P35436 Receptor Membrane + Binding 8768735 GLYCINE NA NA Ligand Extracellular NMDAR Q12879 P35436 Receptor Membrane + Binding 8768735 PSD95 P78352 Q62108 Adapter Cytosol SYNGAP Q96PV0 Q60790 GEF Cytosol 0 Binding 9581761 PSD95 P78352 Q62108 Adapter Cytosol SYNGAP Q96PV0 Q60790 GEF Cytosol 0 Binding 9620694 CALMODULIN P62158 P62204 Activator Cytosol IQGAP P46940 Q9JKF1 GAP Cytosol + Binding 8670801 CALMODULIN P62158 P62204 Activator Cytosol IQGAP P46940 Q9JKF1 GAP Cytosol + Binding 11809768 IQGAP P46940 Q9JKF1 GAP Cytosol RAS P01111 P08556 GTPase Cytosol _ GAP 8670801 INTEGRIN P05556 P09055 CellAdhesion Membrane ILK Q13418 O55222 Kinase Cytosol + Binding 8538749 TCF P36402 Q00417 TF Nucleus LEF1 Q9UJU2 P27782 TF Nucleus + Binding 12032083 LEF1 Q9UJU2 P27782 TF Nucleus MITF O75030 Q08874 TF Nucleus + Binding 12032083 GSK3 P49840 Q9WV60 Kinase Cytosol MITF O75030 Q08874 TF Nucleus + Phosphorylation 10587587 NGF P01138 P20181 Ligand Extracellular TRKA P04629 Q9Z139 Receptor Membrane + Binding 9547236 NGF P01138 P20181 Ligand Extracellular TRKA P04629 Q9Z139 Receptor Membrane + Binding 9290260 NGF P01138 P20181 Ligand Extracellular TRKA P04629 Q9Z139 Receptor Membrane + Binding 1706478 TRKA P04629 Q9Z139 Receptor Membrane PLCGAMMA P19174 Q62077 Phospholipase Cytosol + Binding 8552402 APS O14492 Q9JID9 Adapter Cytosol GRB2 P62993 Q60631 Adapter Cytosol 0 Binding 9856458 APS O14492 Q9JID9 Adapter Cytosol VAV P52735 Q60992 GEF Cytosol + Binding 12400014 LCK P06239 P08103 Kinase Cytosol VAV P52735 Q60992 GEF Cytosol + Phosphorylation 12400014 LCK P06239 P08103 Kinase Cytosol SOS Q07889 Q02384 GEF Cytosol 0 Binding 9856337 GRB2 P62993 Q60631 Adapter Cytosol SOS Q07889 Q02384 GEF Cytosol + Binding 8493579 GRB2 P62993 Q60631 Adapter Cytosol SOS Q07889 Q02384 GEF Cytosol + Binding 8479540 SOS Q07889 Q02384 GEF Cytosol RAS P01111 P08556 GTPase Cytosol + GEF 8493579 SOS Q07889 Q02384 GEF Cytosol RAS P01111 P08556 GTPase Cytosol + GEF 9690470 SOS Q07889 Q02384 GEF Cytosol RAS P01111 P08556 GTPase Cytosol + GEF 7923364 IRS1 P35568 P35569 Adapter Cytosol PI3K P42336 P42337 Kinase Cytosol + Binding 1381348 PI3K P42336 P42337 Kinase Cytosol PIP3 NA NA Lipid Membrane + Phosphorylation 2833705 PI3K P42336 P42337 Kinase Cytosol PIP2 NA NA Lipid Membrane _ Phosphorylation 2833705 PIP3 NA NA Lipid Membrane PDK1 O15530 Q9Z2A0 Kinase Cytosol + Binding 9094314 PDK1 O15530 Q9Z2A0 Kinase Cytosol PKB P31749 Q60823 Kinase Cytosol + Phosphorylation 9094314 PKA P17612 P05132 Kinase Cytosol BAD Q92934 Q61337 Bcl2Family Mitochondria _ Phosphorylation 10851172 RSK Q15418 P18653 Kinase Cytosol BAD Q92934 Q61337 Bcl2Family Mitochondria _ Phosphorylation 10976111 P1433 Q04917 P11576 Adapter Cytosol BAD Q92934 Q61337 Bcl2Family Mitochondria _ Binding 8929531 RIM Q86UR5 Q99NE5 Adapter Vesicles RABPHILIN Q9Y2J0 P47708 Vesicle Vesicles + Binding 11431472 RIM Q86UR5 Q99NE5 Adapter Vesicles P1433 Q04917 P11576 Adapter Cytosol + Binding 12871946 RIM Q86UR5 Q99NE5 Adapter Vesicles RAB3 P20336 P05713 GTPase Vesicles + Binding 9252191 RIM Q86UR5 Q99NE5 Adapter Vesicles RAB3 P20336 P05713 GTPase Vesicles + Binding 11431472 RIM Q86UR5 Q99NE5 Adapter Vesicles MUNC13 O14795 Q9Z1N9 Vesicle Vesicles + Binding 11343654 RIM Q86UR5 Q99NE5 Adapter Vesicles SYNAPTOTAGMIN P21579 P46096 Vesicle Vesicles + Binding 11438518 RIM Q86UR5 Q99NE5 Adapter Vesicles SNAP25 P60878 P60881 Vesicle Vesicles + Binding 11438518 cAMPGEFII Q8WZA2 Q8WZA2 GEF Cytosol RIM Q86UR5 Q99NE5 Adapter Vesicles + Binding 1105653 cAMP NA NA Messenger Cytosol cAMPGEFII Q8WZA2 Q8WZA2 GEF Cytosol + Binding 11056535 BAD Q92934 Q61337 Bcl2Family Mitochondria BCLXL Q07817 P70345 Bcl2Family Mitochondria + Binding 9305851 BAD Q92934 Q61337 Bcl2Family Mitochondria BCLXL Q07817 P70345 Bcl2Family Mitochondria + Binding 9388232 CREB P16220 Q01147 TF Nucleus ATF1 P39905 P81269 TF Nucleus + Binding 1655749 PKA P17612 P05132 Kinase Cytosol ATF1 P39905 P81269 TF Nucleus + Phosphorylation 1655749 PKA P17612 P05132 Kinase Cytosol CREB P16220 Q01147 TF Nucleus + Phosphorylation 2875459 PKA P17612 P05132 Kinase Cytosol CREB P16220 Q01147 TF Nucleus + Phosphorylation 2885756 MAPK P28482 P27703 Kinase Cytosol RSK Q15418 P18653 Kinase Cytosol + Phosphorylation 8202512 MEK1 Q92918 Q8BPM2 Kinase Cytosol MAPK P28482 P27703 Kinase Cytosol + Phosphorylation 1381507 MEK1 Q92918 Q8BPM2 Kinase Cytosol MAPK P28482 P27703 Kinase Cytosol + Phosphorylation 8226933 RAF1 P04049 Q99N57 Kinase Cytosol MEK1 Q92918 Q8BPM2 Kinase Cytosol + Phosphorylation 7624324 PLA2 Q9Y263 Q9Z0Y2 Phospholipase Cytosol AA NA NA Lipid Cytosol + Synthesis 2119631 PLA2 Q9Y263 Q9Z0Y2 Phospholipase Cytosol AA NA NA Lipid Cytosol + Synthesis 874074 AA NA NA Lipid Cytosol PKC P17252 P05697 Kinase Cytosol + Binding 2119631 AA NA NA Lipid Cytosol PKC P17252 P05697 Kinase Cytosol + Binding 3934001 PIP3 NA NA Lipid Membrane PKB P31749 Q60823 Kinase Cytosol + Binding 9445477 PIP2 NA NA Lipid Membrane PKB P31749 Q60823 Kinase Cytosol + Binding 9445477 PIP2 NA NA Lipid Cytosol PMCA P20020 Q9R0K7 Pump Membrane + Binding 11734659 PIP2 NA NA Lipid Cytosol PMCA P20020 Q9R0K7 Pump Membrane + Binding 6455424 PMCA P20020 Q9R0K7 Pump Membrane CALCIUM NA NA Messenger Cytosol _ Pumping 6455424 CALMODULIN P62158 P62204 Activator Cytosol PMCA P20020 Q9R0K7 Pump Membrane + Binding 6455424 CAMP NA NA Messenger Cytosol PKA P17612 P05132 Kinase Cytosol + Binding 2423884 CREB P16220 Q01147 TF Nucleus CRE NA NA DNA Nucleus + Binding 2885756 DAG NA NA Lipid Cytosol PKC P17252 P05697 Kinase Cytosol + Binding 438153 CALCIUM NA NA Messenger Cytosol PKC P17252 P05697 Kinase Cytosol + Binding 438153 FIVEHT1AR P08908 Q64264 Receptor Membrane GALPHAI P08754 Q9DC51 Gprotein Cytosol + Binding 1589591 GALPHAQ P50148 P21279 Gprotein Cytosol PLCBETA Q9NQ66 P51432 Phospholipase Cytosol + Binding 1846707 GALPHAQ P50148 P21279 Gprotein Cytosol PLCBETA Q9NQ66 P51432 Phospholipase Cytosol + Binding 1322796 GALPHAQ P50148 P21279 Gprotein Cytosol PLCBETA Q9NQ66 P51432 Phospholipase Cytosol + Binding 1309799 RSK Q15418 P18653 Kinase Cytosol CREB P16220 Q01147 TF Nucleus + Phosphorylation 8688081 MAPK P28482 P27703 Kinase Cytosol MAPKAPK2 P49137 P49138 Kinase Cytosol + Phosphorylation 1327754 PKA P17612 P05132 Kinase Cytosol SYNAPSIN P17600 O88935 Vesicle Vesicles _ Phosphorylation 3118371 CAMKI Q14012 Q91YS8 Kinase Cytosol SYNAPSIN P17600 O88935 Vesicle Vesicles _ Phosphorylation 3118371 CAMKII Q9UQM7 P11798 Kinase Cytosol SYNAPSIN P17600 O88935 Vesicle Vesicles _ Phosphorylation 3118371 MAPK P28482 P27703 Kinase Cytosol SYNAPSIN P17600 O88935 Vesicle Vesicles _ Phosphorylation 8622996 MAPK P28482 P27703 Kinase Cytosol SYNAPSIN P17600 O88935 Vesicle Vesicles _ Phosphorylation 8702879 CDK5 Q00535 P49615 Kinase Cytosol SYNAPSIN P17600 O88935 Vesicle Vesicles 0 Phosphorylation 8702879 CALCIUM NA NA Messenger Cytosol SYNAPSIN P17600 O88935 Vesicle Vesicles + Binding 9463376 VAV P52735 Q60992 GEF Cytosol RAC P15154 P15154 GTPase Cytosol + GEF 8990121 CAMKII Q9UQM7 P11798 Kinase Cytosol TIAM1 Q13009 Q60610 GEF Cytosol + Phosphorylation 10212259 PKC P17252 P05697 Kinase Cytosol TIAM1 Q13009 Q60610 GEF Cytosol 0 Phosphorylation 10212259 PKC P17252 P05697 Kinase Cytosol TIAM1 Q13009 Q60610 GEF Cytosol 0 Phosphorylation 9407095 TIAM1 Q13009 Q60610 GEF Cytosol RAC P15154 P15154 GTPase Cytosol + GEF 10212259 GRB2 P62993 Q60631 Adapter Cytosol VAV P52735 Q60992 GEF Cytosol + Binding 7809090 ZAP70 P43403 P05480 Kinase Cytosol VAV P52735 Q60992 GEF Cytosol + Binding 7798261 SRC P12931 P05480 Kinase Cytosol VAV P52735 Q60992 GEF Cytosol + Phosphorylation 1311423 SRC P12931 P05480 Kinase Cytosol VAV P52735 Q60992 GEF Cytosol + Phosphorylation 1531699 RASGRP3 Q8IV61 Q91ZC8 GEF Cytosol RAS P01111 P08556 GTPase Cytosol + GEF 10934204 RASGRP3 Q8IV61 Q91ZC8 GEF Cytosol RAP1 P10113 P10113 GTPase Cytosol + GEF 10934204 PKC P17252 P05697 Kinase Cytosol RASGRP3 Q8IV61 Q91ZC8 GEF Cytosol + Phosphorylation 12730099 RAS P01111 P08556 GTPase Cytosol RALGDS Q12967 Q03385 GEF Cytosol + Binding 7809086 RAP1 P10113 P10113 GTPase Cytosol RALGDS Q12967 Q03385 GEF Cytosol + Binding 7809086 RALGDS Q12967 Q03385 GEF Cytosol RAL P11233 P05810 GTPase Cytosol + GEF 8094051 ABL P00519 P00520 Kinase Cytosol GRB2 P62993 Q60631 Adapter Cytosol 0 Binding 8112292 ABL P00519 P00520 Kinase Cytosol SHC P29353 Q61120 Adapter Cytosol 0 Binding 8112292 PSD95 P78352 Q62108 Adapter Cytosol NEUROLIGIN Q8N2Q7 Q99K10 CellAdhesion Membrane 0 Binding 9278515 NOS P29475 Q9Z0J4 Synthase Cytosol NO NA NA Messenger Cytosol + Synthesis 7528745 NOS P29475 Q9Z0J4 Synthase Cytosol NO NA NA Messenger Cytosol + Synthesis 1722402 CALMODULIN P62158 P62204 Activator Cytosol NOS P29475 Q9Z0J4 Synthase Cytosol + Binding 1722402 CALMODULIN P62158 P62204 Activator Cytosol NOS P29475 Q9Z0J4 Synthase Cytosol + Binding 7493936 RAC P15154 P15154 GTPase Cytosol PAK Q13153 O88643 Kinase Cytosol + Binding 8107774 CDC42 P60953 P60766 GTPase Cytosol PAK Q13153 O88643 Kinase Cytosol + Binding 810774 NEUROLIGIN Q8N2Q7 Q99K10 CellAdhesion Membrane NEUREXIN P78357 O54991 CellAdhesion Membrane 0 Binding 7736595 CALCIUM NA NA Messenger Cytosol DREAM Q9Y2W7 Q9QXT8 TF Nucleus + Binding 10078534 DREAM Q9Y2W7 Q9QXT8 TF Nucleus DRE NA NA DNA Nucleus _ Binding 10078534 CREM Q03060 Q01147 TF Nucleus DREAM Q9Y2W7 Q9QXT8 TF Nucleus _ Binding 11094064 DREAM Q9Y2W7 Q9QXT8 TF Nucleus CREB P16220 Q01147 TF Nucleus _ Binding 12198160 MSK1 O75582 Q8C050 Kinase Cytosol CREB P16220 Q01147 TF Nucleus + Phosphorylation 9687510 P38 Q16539 P47811 Kinase Cytosol MSK1 O75582 Q8C050 Kinase Cytosol + Phosphorylation 9687510 MAPK P28482 P27703 Kinase Cytosol MSK1 O75582 Q8C050 Kinase Cytosol + Phosphorylation 9687510 S6K P23443 Q9Z1M4 Kinase Cytosol CREM Q03060 Q01147 TF Nucleus + Phosphorylation 7923380 P38 Q16539 P47811 Kinase Cytosol MAPKAPK2 P49137 P49138 Kinase Cytosol + Phosphorylation 7923353 P38 Q16539 P47811 Kinase Cytosol MAPKAPK2 P49137 P49138 Kinase Cytosol + Phosphorylation 7592979 MAPK P28482 P27703 Kinase Cytosol MAPKAPK2 P49137 P49138 Kinase Cytosol + Phosphorylation 7592979 NCK P16333 Q60631 Adapter Cytosol PAK Q13153 O88643 Kinase Cytosol + Binding 9024622 NCK P16333 Q60631 Adapter Cytosol PAK Q13153 O88643 Kinase Cytosol + Binding 11096073 NCK P16333 Q60631 Adapter Cytosol PAK Q13153 O88643 Kinase Cytosol + Binding 8824201 NCK P16333 Q60631 Adapter Cytosol PAK Q13153 O88643 Kinase Cytosol + Binding 9755165 MEK6 Q8N4C8 Q8N4C8 Kinase Cytosol P38 Q16539 P47811 Kinase Cytosol + Phosphorylation 8626699 P38 Q16539 P47811 Kinase Cytosol MNK1 Q9BXL6 Q99KF0 Kinase Cytosol + Phosphorylation 9155018 MAPK P28482 P27703 Kinase Cytosol MNK1 Q9BXL6 Q99KF0 Kinase Cytosol + Phosphorylation 9155018 P38 Q16539 P47811 Kinase Cytosol MNK1 Q9BXL6 Q99KF0 Kinase Cytosol + Phosphorylation 9155017 MAPK P28482 P27703 Kinase Cytosol MNK1 Q9BXL6 Q99KF0 Kinase Cytosol + Phosphorylation 9155017 MNK1 Q9BXL6 Q99KF0 Kinase Cytosol EIF4E P06730 P20415 Adapter Ribosomes + Phosphorylation 9155017 MNK1 Q9BXL6 Q99KF0 Kinase Cytosol EIF4E P06730 P20415 Adapter Ribosomes + Phosphorylation 10022874 CBP Q92793 P45481 TF Nucleus SRF P11831 NA TF Nucleus 0 Binding 9388250 SRF P11831 NA TF Nucleus SRE NA NA DNA Nucleus 0 Binding 3203386 TCF P36402 Q00417 TF Nucleus SRE NA NA DNA Nucleus 0 Binding 2492906 SRF P11831 NA TF Nucleus SRE NA NA DNA Nucleus 0 Binding 2108863 TCF P36402 Q00417 TF Nucleus SRE NA NA DNA Nucleus 0 Binding 2108863 TCF P36402 Q00417 TF Nucleus SRF P11831 NA TF Nucleus + Binding 2108863 ELK1 P19419 P41969 TF Nucleus SRE NA NA DNA Nucleus + Binding 1722028 ELK1 P19419 P41969 TF Nucleus TCF P36402 Q00417 TF Nucleus 0 Binding 1722028 MAPK P28482 P27703 Kinase Cytosol ELK1 P19419 P41969 TF Nucleus + Phosphorylation 8477450 MAPK P28482 P27703 Kinase Cytosol ELK1 P19419 P41969 TF Nucleus + Phosphorylation 9501095 CBP Q92793 P45481 TF Nucleus AP1 P05412 P05627 TF Nucleus + Binding 8545107 CBP Q92793 P45481 TF Nucleus STAT P42224 P42227 TF Nucleus 0 Binding 8848048 CBP Q92793 P45481 TF Nucleus ELK1 P19419 P41969 TF Nucleus + Binding 8941362 CBP Q92793 P45481 TF Nucleus TCF P36402 Q00417 TF Nucleus _ Binding 9388250 CALMODULIN P62158 P62204 Activator Cytosol CAMKIV Q16566 P08414 Kinase Cytosol + Binding 8340352 CALMODULIN P62158 P62204 Activator Cytosol AC1 Q08828 Q01341 Cyclase Cytosol + Binding 8417150 CALMODULIN P62158 P62204 Activator Cytosol AC1 Q08828 Q01341 Cyclase Cytosol + Binding 7685187 CALMODULIN P62158 P62204 Activator Cytosol AC1 Q08828 Q01341 Cyclase Cytosol + Binding 2022671 CALMODULIN P62158 P62204 Activator Cytosol CALCINEURIN P06705 P61023 Phosphatase Cytosol + Binding 293720 GBETAGAMMA P11016 P11016 Gprotein Cytosol PLCBETA Q9NQ66 P51432 Phospholipase Cytosol + Binding 1465133 GBETAGAMMA P11016 P11016 Gprotein Cytosol PLCBETA Q9NQ66 P51432 Phospholipase Cytosol + Binding 8387502 GBETAGAMMA P11016 P11016 Gprotein Cytosol PLCBETA Q9NQ66 P51432 Phospholipase Cytosol + Binding 8306983 GBETAGAMMA P11016 P11016 Gprotein Cytosol PLCBETA Q9NQ66 P51432 Phospholipase Cytosol + Binding 1465134 GBETAGAMMA P11016 P11016 Gprotein Cytosol PLCBETA Q9NQ66 P51432 Phospholipase Cytosol + Binding 9307019 GALPHAQ P50148 P21279 Gprotein Cytosol PLCBETA Q9NQ66 P51432 Phospholipase Cytosol + Binding 8387502 CAMKIV Q16566 P08414 Kinase Cytosol CREB P16220 Q01147 TF Nucleus + Phosphorylation 8195196 CAMKIV Q16566 P08414 Kinase Cytosol CREB P16220 Q01147 TF Nucleus + Phosphorylation 11970865 NMDAR Q12879 P35436 Receptor Membrane CALCIUM NA NA Messenger Cytosol + Opening 3012362 ACH NA NA Ligand Extracellular M2R P08172 Q9ERZ4 Receptor Membrane + Binding 3037705 ACH NA NA Ligand Extracellular M2R P08172 Q9ERZ4 Receptor Membrane + Binding 3107123 ACH NA NA Ligand Extracellular M2R P08172 Q9ERZ4 Receptor Membrane + Binding 12799142 M2R P08172 Q9ERZ4 Receptor Membrane GALPHAI P08754 Q9DC51 Gprotein Cytosol + Binding 8786435 M2R P08172 Q9ERZ4 Receptor Membrane GALPHAI P08754 Q9DC51 Gprotein Cytosol + Binding 3919024 M2R P08172 Q9ERZ4 Receptor Membrane GALPHAI P08754 Q9DC51 Gprotein Cytosol + Binding 3929139 M2R P08172 Q9ERZ4 Receptor Membrane GBETAGAMMA P11016 P11016 Gprotein Cytosol + Binding 8786435 M2R P08172 Q9ERZ4 Receptor Membrane GBETAGAMMA P11016 P11016 Gprotein Cytosol + Binding 3037705 GBETAGAMMA P11016 P11016 Gprotein Cytosol RASGAP Q8IV61 Q91ZC8 GAP Cytosol + Binding 8714559 GBETAGAMMA P11016 P11016 Gprotein Cytosol bARK P25098 O70293 Kinase Cytosol + Binding 1325672 GBETAGAMMA P11016 P11016 Gprotein Cytosol AC2 Q08462 Q91WF3 Cyclase Cytosol + Binding 1962211 GBETAGAMMA P11016 P11016 Gprotein Cytosol AC2 Q08462 Q91WF3 Cyclase Cytosol + Binding 1312225 GBETAGAMMA P11016 P11016 Gprotein Cytosol bARK P25098 O70293 Kinase Cytosol + Binding 1962211 GBETAGAMMA P11016 P11016 Gprotein Cytosol bARK P25098 O70293 Kinase Cytosol + Binding 8416978 CALMODULIN P62158 P62204 Activator Cytosol NOS P29475 Q9Z0J4 Synthase Cytosol + Binding 7685187 BETACATENIN P35222 Q02248 TF Cytosol LEF Q9UJU2 P27782 TF Nucleus + Binding 8892228 BETACATENIN P35222 Q02248 TF Cytosol LEF Q9UJU2 P27782 TF Nucleus + Binding 8757136 RAS P01111 P08556 GTPase Cytosol PI3K P42336 P42337 Kinase Cytosol + Binding 9150145 RAS P01111 P08556 GTPase Cytosol PI3K P42336 P42337 Kinase Cytosol + Binding 7820549 RAS P01111 P08556 GTPase Cytosol PI3K P42336 P42337 Kinase Cytosol + Binding 8052307 GBETAGAMMA P11016 P11016 Gprotein Cytosol PI3K P42336 P42337 Kinase Cytosol + Binding 8156600 BETACATENIN P35222 Q02248 TF Cytosol TCF P36402 Q00417 TF Nucleus + Binding 9065401 GBETAGAMMA P11016 P11016 Gprotein Cytosol NTYPECA Q00975 P97445 Channel Membrane _ Binding 9009193 GBETAGAMMA P11016 P11016 Gprotein Cytosol NTYPECA Q00975 P97445 Channel Membrane _ Binding 10692440 IRS1 P35568 P35569 Adapter Cytosol GRB2 P62993 Q60631 Adapter Cytosol + Binding 8491186 IRS1 P35568 P35569 Adapter Cytosol GRB2 P62993 Q60631 Adapter Cytosol + Binding 8114695 SHC P29353 Q61120 Adapter Cytosol GRB2 P62993 Q60631 Adapter Cytosol 0 Binding 8491186 SHC P29353 Q61120 Adapter Cytosol GRB2 P62993 Q60631 Adapter Cytosol 0 Binding 9566877 SHC P29353 Q61120 Adapter Cytosol GRB2 P62993 Q60631 Adapter Cytosol 0 Binding 1465135 SHC P29353 Q61120 Adapter Cytosol GRB2 P62993 Q60631 Adapter Cytosol 0 Binding 8114695 INSULIN NA NA Ligand Extracellular IR P06213 P15208 Receptor Membrane + Binding 6986652 INSULIN NA NA Ligand Extracellular IR P06213 P15208 Receptor Membrane + Binding 2983222 INSULIN NA NA Ligand Extracellular IR P06213 P15208 Receptor Membrane + Binding 205798 IRS1 P35568 P35569 Adapter Cytosol PI3K P42336 P42337 Kinase Cytosol + Binding 1380456 IRS1 P35568 P35569 Adapter Cytosol NCK P16333 Q60631 Adapter Cytosol + Binding 8265614 IR P06213 P15208 Receptor Membrane IRS1 P35568 P35569 Adapter Cytosol + Phosphorylation 1385403 IR P06213 P15208 Receptor Membrane IRS1 P35568 P35569 Adapter Cytosol + Phosphorylation 2159922 PA NA NA Messenger Cytosol SHP1 Q96B97 Q9JLQ0 Phosphatase Cytosol + Binding 10508402 PIP3 NA NA Lipid Membrane SHP1 Q96B97 Q9JLQ0 Phosphatase Cytosol + Binding 10508402 JAK O60674 Q62120 Kinase Cytosol STAT P42224 P42227 TF Nucleus + Phosphorylation 7504784 JAK O60674 Q62120 Kinase Cytosol STAT P42224 P42227 TF Nucleus + Phosphorylation 7504785 GBETAGAMMA P11016 P11016 Gprotein Cytosol IRS1 P35568 P35569 Adapter Cytosol + Binding 7619809 PIP2 NA NA Lipid Cytosol bARK P25098 O70293 Kinase Cytosol _ Binding 7673171 PKC P17252 P05697 Kinase Cytosol NMDAR Q12879 P35436 Receptor Membrane _ Phosphorylation 8316301 SSTR1 P30872 P30873 Receptor Membrane GALPHAI P08754 Q9DC51 Gprotein Cytosol + Binding 8145728 SSTR1 P30872 P30873 Receptor Membrane GBETAGAMMA P11016 P11016 Gprotein Cytosol + Binding 8145728 SSTR1 P30872 P30873 Receptor Membrane GALPHAO P09471 P18872 Gprotein Cytosol + Binding 8145728 SS NA NA Ligand Extracellular SSTR1 P30872 P30873 Receptor Membrane + Binding 8145728 SS NA NA Ligand Extracellular SSTR2 P30874 O08858 Receptor Membrane + Binding 15181094 SS NA NA Ligand Extracellular SSTR1 P30872 P30873 Receptor Membrane + Binding 1346068 SS NA NA Ligand Extracellular SSTR2 P30874 O08858 Receptor Membrane + Binding 1346068 SSTR2 P30874 O08858 Receptor Membrane SHP1 Q96B97 Q9JLQ0 Phosphatase Cytosol + Binding 9305905 D1R P21728 Q61616 Receptor Membrane GALPHAS P04895 P04894 Gprotein Cytosol + Binding 1832710 D1R P21728 Q61616 Receptor Membrane GALPHAI P08754 Q9DC51 Gprotein Cytosol + Binding 1832710 SSTR2 P30874 O08858 Receptor Membrane GALPHAO P09471 P18872 Gprotein Cytosol + Binding 1374909 SSTR2 P30874 O08858 Receptor Membrane GALPHAI P08754 Q9DC51 Gprotein Cytosol + Binding 1374909 SSTR2 P30874 O08858 Receptor Membrane GBETAGAMMA P11016 P11016 Gprotein Cytosol + Binding 1374909 PAF NA NA Ligand Extracellular PAFR P25105 Q62035 Receptor Membrane + Binding 1323312 PAF NA NA Ligand Extracellular PAFR P25105 Q62035 Receptor Membrane + Binding 12106349 PAF NA NA Ligand Extracellular PAFR P25105 Q62035 Receptor Membrane + Binding 2831903 PAF NA NA Ligand Extracellular PAFR P25105 Q62035 Receptor Membrane + Binding 1846231 FIVEHT2AR P28223 P35363 Receptor Membrane GALPHAQ P50148 P21279 Gprotein Cytosol + Binding 6483122 PAFR P25105 Q62035 Receptor Membrane GALPHAO P09471 P18872 Gprotein Cytosol + Binding 1311408 PAFR P25105 Q62035 Receptor Membrane GALPHAO P09471 P18872 Gprotein Cytosol + Binding 3013161 PAFR P25105 Q62035 Receptor Membrane GALPHAQ P50148 P21279 Gprotein Cytosol + Binding 8576109 M1R P11229 P12657 Receptor Membrane GALPHAQ P50148 P21279 Gprotein Cytosol + Binding 1341877 M1R P11229 P12657 Receptor Membrane GALPHAQ P50148 P21279 Gprotein Cytosol + Binding 3110621 M1R P11229 P12657 Receptor Membrane GALPHAQ P50148 P21279 Gprotein Cytosol + Binding 8576109 PAFR P25105 Q62035 Receptor Membrane GBETAGAMMA P11016 P11016 Gprotein Cytosol + Binding 1311408 PAFR P25105 Q62035 Receptor Membrane GBETAGAMMA P11016 P11016 Gprotein Cytosol + Binding 8858930 PAFR P25105 Q62035 Receptor Membrane GBETAGAMMA P11016 P11016 Gprotein Cytosol + Binding 7797472 ACH NA NA Ligand Extracellular M1R P11229 P12657 Receptor Membrane + Binding 1341877 ACH NA NA Ligand Extracellular M1R P11229 P12657 Receptor Membrane + Binding 12859343 M2R P08172 Q9ERZ4 Receptor Membrane GALPHAO P09471 P18872 Gprotein Cytosol + Binding 2850835 M2R P08172 Q9ERZ4 Receptor Membrane GALPHAO P09471 P18872 Gprotein Cytosol + Binding 2823384 M1R P11229 P12657 Receptor Membrane GALPHA11 P29992 P21279 Gprotein Cytosol + Binding 12200418 GALPHA13 Q14344 P27601 Gprotein Cytosol PYK2 Q14289 Q60629 Kinase Cytosol + Binding 10821841 FIVEHT1AR P08908 Q64264 Receptor Membrane GALPHAS P04895 P04894 Gprotein Cytosol + Binding 2941565 FIVEHT1AR P08908 Q64264 Receptor Membrane GBETAGAMMA P11016 P11016 Gprotein Cytosol + Binding 2941565 PDK1 O15530 Q9Z2A0 Kinase Cytosol RSK Q15418 P18653 Kinase Cytosol + Phosphorylation 10480933 GRB2 P62993 Q60631 Adapter Cytosol SAM68 Q8TCZ4 Q64213 Adapter Cytosol + Binding 12112020 FIVEHT4R Q13639 P97288 Receptor Membrane GALPHAS P04895 P04894 Gprotein Cytosol + Binding 2314390 FIVEHT2AR P28223 P35363 Receptor Membrane GBETAGAMMA P11016 P11016 Gprotein Cytosol + Binding 6483122 FIVEHT4R Q13639 P97288 Receptor Membrane GBETAGAMMA P11016 P11016 Gprotein Cytosol + Binding 2314390 SEROTONIN NA NA Ligand Extracellular FIVEHT4R Q13639 P97288 Receptor Membrane + Binding 2314390 SEROTONIN NA NA Ligand Extracellular FIVEHT2AR P28223 P35363 Receptor Membrane + Binding 6483122 SAM68 Q8TCZ4 Q64213 Adapter Cytosol RASGAP Q8IV61 Q91ZC8 GAP Cytosol 0 Binding 9571195 SAM68 Q8TCZ4 Q64213 Adapter Cytosol RASGAP Q8IV61 Q91ZC8 GAP Cytosol 0 Binding 9743338 FYN P06241 P39688 Kinase Cytosol SAM68 Q8TCZ4 Q64213 Adapter Cytosol 0 Phosphorylation 14647465 SAM68 Q8TCZ4 Q64213 Adapter Cytosol PLCGAMMA P19174 Q62077 Phospholipase Cytosol 0 Binding 14647465 SAM68 Q8TCZ4 Q64213 Adapter Cytosol mRNA NA NA RNA Ribosomes 0 Binding 7512694 SRC P12931 P05480 Kinase Cytosol SAM68 Q8TCZ4 Q64213 Adapter Cytosol + Phosphorylation 7512694 SRC P12931 P05480 Kinase Cytosol SAM68 Q8TCZ4 Q64213 Adapter Cytosol + Phosphorylation 2236073 SRC P12931 P05480 Kinase Cytosol SAM68 Q8TCZ4 Q64213 Adapter Cytosol + Phosphorylation 14643926 DOPAMINE NA NA Ligand Extracellular D1R P21728 Q61616 Receptor Membrane + Binding 2898118 DOPAMINE NA NA Ligand Extracellular D1R P21728 Q61616 Receptor Membrane + Binding 2168556 DOPAMINE NA NA Ligand Extracellular D2R P14416 P61168 Receptor Membrane + Binding 2898118 DOPAMINE NA NA Ligand Extracellular D2R P14416 P61168 Receptor Membrane + Binding 2532362 DOPAMINE NA NA Ligand Extracellular D2R P14416 P61168 Receptor Membrane + Binding 2532359 D2R P14416 P61168 Receptor Membrane GALPHAI P08754 Q9DC51 Gprotein Cytosol + Binding 2898118 D1R P21728 Q61616 Receptor Membrane GALPHAS P04895 P04894 Gprotein Cytosol + Binding 2898118 D2R P14416 P61168 Receptor Membrane GBETAGAMMA P11016 P11016 Gprotein Cytosol + Binding 12869650 PKA P17612 P05132 Kinase Cytosol PLCGAMMA P19174 Q62077 Phospholipase Cytosol _ Phosphorylation 2479646 PLCGAMMA P19174 Q62077 Phospholipase Cytosol DAG NA NA Lipid Cytosol + Synthesis 2831461 PLCGAMMA P19174 Q62077 Phospholipase Cytosol IP3 NA NA Lipid Cytosol + Synthesis 2831461 PLCGAMMA P19174 Q62077 Phospholipase Cytosol IP3 NA NA Lipid Cytosol + Synthesis 3541924 PLCGAMMA P19174 Q62077 Phospholipase Cytosol IP3 NA NA Lipid Cytosol + Synthesis 3040753 PLCGAMMA P19174 Q62077 Phospholipase Cytosol IP3 NA NA Lipid Cytosol + Synthesis 2840660 PLCBETA Q9NQ66 P51432 Phospholipase Cytosol IP3 NA NA Lipid Cytosol + Cleavage 6325926 PLCBETA Q9NQ66 P51432 Phospholipase Cytosol IP3 NA NA Lipid Cytosol + Cleavage 6095092 PLCBETA Q9NQ66 P51432 Phospholipase Cytosol DAG NA NA Lipid Cytosol + Cleavage 6325926 PLCBETA Q9NQ66 P51432 Phospholipase Cytosol DAG NA NA Lipid Cytosol + Cleavage 7076678 PLCBETA Q9NQ66 P51432 Phospholipase Cytosol IP3 NA NA Lipid Cytosol + Cleavage 7076678 PLCBETA Q9NQ66 P51432 Phospholipase Cytosol DAG NA NA Lipid Cytosol + Cleavage 7142213 PLCBETA Q9NQ66 P51432 Phospholipase Cytosol IP3 NA NA Lipid Cytosol + Cleavage 7142213 GLUTAMATE NA NA Ligand Extracellular MGLUR1 Q13255 P97772 Receptor Membrane + Binding 2559758 GLUTAMATE NA NA Ligand Extracellular MGLUR1 Q13255 P97772 Receptor Membrane + Binding 1656524 MGLUR1 Q13255 P97772 Receptor Membrane GALPHA11 P29992 P21279 Gprotein Cytosol + Binding 12351712 MGLUR1 Q13255 P97772 Receptor Membrane GALPHAQ P50148 P21279 Gprotein Cytosol + Binding 12351712 MGLUR1 Q13255 P97772 Receptor Membrane GBETAGAMMA P11016 P11016 Gprotein Cytosol + Binding 1656524 SHP1 Q96B97 Q9JLQ0 Phosphatase Cytosol RET P09455 Q00915 Receptor Membrane _ Dephosphorylation 11564708 RET P09455 Q00915 Receptor Membrane IRS1 P35568 P35569 Adapter Cytosol 0 Binding 11313948 RET P09455 Q00915 Receptor Membrane SHC P29353 Q61120 Adapter Cytosol 0 Binding 11313948 GDNF NA NA Ligand Extracellular RET P09455 Q00915 Receptor Membrane + Binding 10995764 RET P09455 Q00915 Receptor Membrane GRB2 P62993 Q60631 Adapter Cytosol + Binding 10995764 RET P09455 Q00915 Receptor Membrane SHC P29353 Q61120 Adapter Cytosol 0 Binding 10995764 PKA P17612 P05132 Kinase Cytosol NFKB P19838 P25799 TF Nucleus + Phosphorylation 15197457 MAPK P28482 P27703 Kinase Cytosol CBP Q92793 P45481 TF Nucleus + Phosphorylation 8941362 CALCINEURIN P06705 P61023 Phosphatase Cytosol NFAT O95644 O88942 TF Nucleus + Dephosphorylation 8631904 CALCINEURIN P06705 P61023 Phosphatase Cytosol NFAT O95644 O88942 TF Nucleus + Dephosphorylation 15364589 APAF1 O14727 O88879 Adapter Cytosol CASPASE9 P55211 Q9R0T0 Protease Cytosol + Cleavage 10617566 BAP31 P51572 Q61335 Adapter ER CASPASE8 Q14790 O89110 Protease Cytosol _ Binding 9334338 BAP31 P51572 Q61335 Adapter ER BCL2 P10415 Q64373 Bcl2Family Mitochondria + Binding 9334338 BAP31 P51572 Q61335 Adapter ER BCLXL Q07817 P70345 Bcl2Family Mitochondria + Binding 9334338 CASPASE8 Q14790 O89110 Protease Cytosol CASPASE3 P42574 P70677 Protease Cytosol + Cleavage 8962078 CASPASE8 Q14790 O89110 Protease Cytosol BID P55957 P70444 Bcl2Family Cytosol + Cleavage 9727492 FADD Q13158 Q61160 Adapter Cytosol CASPASE8 Q14790 O89110 Protease Cytosol + Binding 8681377 FAS P25445 P25446 Receptor Membrane FADD Q13158 Q61160 Adapter Cytosol + Binding 8521815 BID P55957 P70444 Bcl2Family Cytosol CYTOCHROMEC P10606 P19536 Activator Mitochondria + Binding 9727492 FASL P48023 P41047 Ligand Extracellular FAS P25445 P25446 Receptor Membrane + Binding 1375228 FASL P48023 P41047 Ligand Extracellular FAS P25445 P25446 Receptor Membrane + Binding 1713127 FASL P48023 P41047 Ligand Extracellular FAS P25445 P25446 Receptor Membrane + Binding 7505205 BAX Q07812 Q07813 Bcl2Family Mitochondria CYTOCHROMEC P10606 P19536 Activator Mitochondria + Binding 11139284 PHAP P39687 O35381 Activator Cytosol APAF1 O14727 O88879 Adapter Cytosol + Binding 12522243 CALCIUM NA NA Messenger Cytosol CALNEXIN P27824 P35564 Chaperone ER + Binding 1918067 SRC P12931 P05480 Kinase Cytosol SHC P29353 Q61120 Adapter Cytosol + Phosphorylation 1409579 SRC P12931 P05480 Kinase Cytosol SHC P29353 Q61120 Adapter Cytosol + Phosphorylation 10329689 PYK2 Q14289 Q60629 Kinase Cytosol SRC P12931 P05480 Kinase Cytosol + Binding 10329689 CALCIUM NA NA Messenger Cytosol CALRETICULIN P27797 P14211 Chaperone ER + Binding 3968084 SEC63P Q9UGP8 Q9QYI4 Adapter ER BIP P11021 P08109 Chaperone ER + Binding 10400622 PIP2 NA NA Lipid Cytosol ARNO Q99418 P97695 GEF Cytosol + Binding 9268368 PIP2 NA NA Lipid Cytosol ARNO Q99418 P97695 GEF Cytosol + Binding 10801341 PIP3 NA NA Lipid Membrane ARNO Q99418 P97695 GEF Cytosol + Binding 10449335 FOUREBP1 O60516 Q80VV3 TF Nucleus EIF4E P06730 P20415 Adapter Ribosomes + Binding 9472019 FOUREBP1 O60516 Q80VV3 TF Nucleus EIF4E P06730 P20415 Adapter Ribosomes + Binding 7935836 MTOR P42345 Q9JLN9 Kinase Cytosol PHAS Q13541 P70445 Inhibitor Ribosomes _ Phosphorylation 8895571 TRKB Q16620 Q9Z139 Receptor Membrane FYN P06241 P39688 Kinase Cytosol + Binding 9648856 BDNF P23560 P21237 Ligand Extracellular TRKB Q16620 Q9Z139 Receptor Membrane + Binding 9648856 FYN P06241 P39688 Kinase Cytosol NMDAR Q12879 P35436 Receptor Membrane + Phosphorylation 11677266 FYN P06241 P39688 Kinase Cytosol NMDAR Q12879 P35436 Receptor Membrane + Phosphorylation 9670010 SRC P12931 P05480 Kinase Cytosol NMDAR Q12879 P35436 Receptor Membrane + Phosphorylation 11677266 CALPAIN P07384 O35350 Protease Cytosol NMDAR Q12879 P35436 Receptor Membrane _ Cleavage 11677266 NMDAR Q12879 P35436 Receptor Membrane SPECTRIN O15020 Q62261 Cytoskeleton Cytosol 0 Binding 11677266 NMDAR Q12879 P35436 Receptor Membrane SPECTRIN O15020 Q62261 Cytoskeleton Cytosol 0 Binding 9670010 NMDAR Q12879 P35436 Receptor Membrane PSD95 P78352 Q62108 Adapter Cytosol 0 Binding 11677266 FYN P06241 P39688 Kinase Cytosol BETACATENIN P35222 Q02248 TF Cytosol + Phosphorylation 12640114 FER P16591 NA Kinase Cytosol BETACATENIN P35222 Q02248 TF Cytosol + Phosphorylation 12640114 ALPHACATENIN P35221 P26231 Cytoskeleton Cytosol BETACATENIN P35222 Q02248 TF Cytosol 0 Binding 12640114 NEUROLIGIN Q8N2Q7 Q99K10 CellAdhesion Membrane NEUREXIN P78357 O54991 CellAdhesion Membrane 0 Binding 9325340 D2R P14416 P61168 Receptor Membrane GALPHAO P09471 P18872 Gprotein Cytosol + Binding 1445393 D2R P14416 P61168 Receptor Membrane GALPHAI P08754 Q9DC51 Gprotein Cytosol + Binding 1445393 LIMK P53667 P53668 Kinase Cytosol COFILIN P23528 P18760 Cytoskeleton Cytosol _ Phosphorylation 9655398 LIMK P53667 P53668 Kinase Cytosol COFILIN P23528 P18760 Cytoskeleton Cytosol _ Phosphorylation 12361576 PAK Q13153 O88643 Kinase Cytosol RAF1 P04049 Q99N57 Kinase Cytosol + Phosphorylation 9823899 PAK Q13153 O88643 Kinase Cytosol COOL Q14155 Q9ES28 GEF Cytosol + Binding 9659915 COOL Q14155 Q9ES28 GEF Cytosol RHO Q07960 Q8C0D4 GTPase Cytosol + Binding 9659915 COOL Q14155 Q9ES28 GEF Cytosol RAC P15154 P15154 GTPase Cytosol + GEF 9659915 COOL Q14155 Q9ES28 GEF Cytosol CDC42 P60953 P60766 GTPase Cytosol + GEF 9659915 RHO Q07960 Q8C0D4 GTPase Cytosol ROCK O75116 P70336 Kinase Cytosol + Binding 8772201 P1433 Q04917 P11576 Adapter Cytosol COFILIN P23528 P18760 Cytoskeleton Cytosol _ Binding 12361576 PAK Q13153 O88643 Kinase Cytosol LIMK P53667 P53668 Kinase Cytosol + Phosphorylation 11413130 ROCK O75116 P70336 Kinase Cytosol LIMK P53667 P53668 Kinase Cytosol + Phosphorylation 10436159 LIMK P53667 P53668 Kinase Cytosol COFILIN P23528 P18760 Cytoskeleton Cytosol _ Phosphorylation 10436159 IP3 NA NA Lipid Cytosol IP3R Q14643 P11881 Channel ER + Binding 1374893 IP3 NA NA Lipid Cytosol IP3R Q14643 P11881 Channel ER + Binding 2826483 IP3 NA NA Lipid Cytosol IP3R Q14643 P11881 Channel ER + Binding 3027583 PKA P17612 P05132 Kinase Cytosol IP3R Q14643 P11881 Channel ER _ Phosphorylation 2847175 PKA P17612 P05132 Kinase Cytosol IP3R Q14643 P11881 Channel ER _ Phosphorylation 1847804 IP3 NA NA Lipid Cytosol IP3R Q14643 P11881 Channel ER + Binding 2847175 SYNDECAN P18827 P18828 Receptor Membrane SYNTENIN O00560 Q99JZ0 Adapter Cytosol 0 Binding 9391086 SYNDECAN P18827 P18828 Receptor Membrane SYNTENIN O00560 Q99JZ0 Adapter Cytosol 0 Binding 11179419 SYNDECAN P18827 P18828 Receptor Membrane SYNTENIN O00560 Q99JZ0 Adapter Cytosol 0 Binding 10770943 SYNTENIN O00560 Q99JZ0 Adapter Cytosol MGLUR7 Q14831 P35400 Receptor Membrane 0 Binding 11891216 GRIP Q96CN9 Q9QYE6 Adapter Cytosol MGLUR7 Q14831 P35400 Receptor Membrane 0 Binding 11891216 SYNTENIN O00560 Q99JZ0 Adapter Cytosol MERLIN P35240 P46662 Adapter Cytosol 0 Binding 11891216 SYNTENIN O00560 Q99JZ0 Adapter Cytosol AMPAR P42261 P23818 Channel Membrane 0 Binding 11891216 CAMKII Q9UQM7 P11798 Kinase Cytosol AMPAR P42261 P23818 Channel Membrane + Phosphorylation 7509863 PKC P17252 P05697 Kinase Cytosol NOS P29475 Q9Z0J4 Synthase Cytosol _ Phosphorylation 7694293 CAMKII Q9UQM7 P11798 Kinase Cytosol NOS P29475 Q9Z0J4 Synthase Cytosol _ Phosphorylation 10874031 CAMKII Q9UQM7 P11798 Kinase Cytosol NOS P29475 Q9Z0J4 Synthase Cytosol _ Phosphorylation 10400690 CAMKIV Q16566 P08414 Kinase Cytosol NOS P29475 Q9Z0J4 Synthase Cytosol _ Phosphorylation 10400690 PKA P17612 P05132 Kinase Cytosol NOS P29475 Q9Z0J4 Synthase Cytosol _ Phosphorylation 7532810 CALMODULIN P62158 P62204 Activator Cytosol MLCK Q15746 Q8VDF3 Kinase Cytosol + Binding 6893940 CALMODULIN P62158 P62204 Activator Cytosol MLCK Q15746 Q8VDF3 Kinase Cytosol + Binding 6934518 MLCK Q15746 Q8VDF3 Kinase Cytosol MYOSIN Q92614 Q9JMH9 Cytoskeleton Cytosol + Phosphorylation 6893940 MLCK Q15746 Q8VDF3 Kinase Cytosol MYOSIN Q92614 Q9JMH9 Cytoskeleton Cytosol + Phosphorylation 4522294 MLCK Q15746 Q8VDF3 Kinase Cytosol MYOSIN Q92614 Q9JMH9 Cytoskeleton Cytosol + Phosphorylation 6934518 EEF2K O00418 O08796 GTPase Ribosomes EEF2 P13639 P58252 GTPase Ribosomes _ Phosphorylation 3693353 EEF2K O00418 O08796 GTPase Ribosomes EEF2 P13639 P58252 GTPase Ribosomes _ Phosphorylation 9133370 EEF2K O00418 O08796 GTPase Ribosomes EEF2 P13639 P58252 GTPase Ribosomes _ Phosphorylation 3906654 EEF2K O00418 O08796 GTPase Ribosomes EEF2 P13639 P58252 GTPase Ribosomes _ Phosphorylation 2704236 EEF2K O00418 O08796 GTPase Ribosomes EEF2 P13639 P58252 GTPase Ribosomes _ Phosphorylation 2458772 CALMODULIN P62158 P62204 Activator Cytosol EEF2K O00418 O08796 GTPase Ribosomes + Binding 3693353 CALMODULIN P62158 P62204 Activator Cytosol EEF2K O00418 O08796 GTPase Ribosomes + Binding 3906654 RSK Q15418 P18653 Kinase Cytosol EEF2K O00418 O08796 GTPase Ribosomes _ Phosphorylation 11500364 S6K P23443 Q9Z1M4 Kinase Cytosol EEF2K O00418 O08796 GTPase Ribosomes _ Phosphorylation 11500364 MTOR P42345 Q9JLN9 Kinase Cytosol S6K P23443 Q9Z1M4 Kinase Cytosol + Phosphorylation 11500364 MAPK P28482 P27703 Kinase Cytosol RSK Q15418 P18653 Kinase Cytosol + Phosphorylation 11500364 L1 P32004 P11627 CellAdhesion Membrane AP2 P53680 P61966 Adapter Vesicles 0 Binding 12070130 L1 P32004 P11627 CellAdhesion Membrane EZRIN P15311 P26041 Cytoskeleton Cytosol + Binding 12070130 THC NA NA Ligand Extracellular CB1R P21554 P47746 Receptor Membrane + Binding 2165569 THC NA NA Ligand Extracellular CB1R P21554 P47746 Receptor Membrane + Binding 2308954 CB1R P21554 P47746 Receptor Membrane GBETAGAMMA P11016 P11016 Gprotein Cytosol + Binding 2165569 FAK Q05397 Q60750 Kinase Cytosol FYN P06241 P39688 Kinase Cytosol + Binding 7505391 FAK Q05397 Q60750 Kinase Cytosol SRC P12931 P05480 Kinase Cytosol + Binding 7505391 RABPHILIN Q9Y2J0 P47708 Vesicle Vesicles RAB3 P20336 P05713 GTPase Vesicles + Binding 8262955 RABPHILIN Q9Y2J0 P47708 Vesicle Vesicles RAB3 P20336 P05713 GTPase Vesicles + Binding 8266731 CALCIUM NA NA Messenger Cytosol RABPHILIN Q9Y2J0 P47708 Vesicle Vesicles + Binding 8262955 PIP2 NA NA Lipid Cytosol RABPHILIN Q9Y2J0 P47708 Vesicle Vesicles + Binding 8262955 PKA P17612 P05132 Kinase Cytosol RABPHILIN Q9Y2J0 P47708 Vesicle Vesicles + Phosphorylation 7891174 PKA P17612 P05132 Kinase Cytosol RABPHILIN Q9Y2J0 P47708 Vesicle Vesicles + Phosphorylation 9425005 CAMKII Q9UQM7 P11798 Kinase Cytosol RABPHILIN Q9Y2J0 P47708 Vesicle Vesicles + Phosphorylation 7891174 CAMKII Q9UQM7 P11798 Kinase Cytosol RABPHILIN Q9Y2J0 P47708 Vesicle Vesicles + Phosphorylation 9425005 FAK Q05397 Q60750 Kinase Cytosol IRS1 P35568 P35569 Adapter Cytosol 0 Binding 9822703 PROFILIN P47756 P47757 Cytoskeleton Cytosol ACTIN P60712 P60711 Cytoskeleton Cytosol + Binding 9463375 PROFILIN P47756 P47757 Cytoskeleton Cytosol ACTIN P60712 P60711 Cytoskeleton Cytosol + Binding 6893804 PROFILIN P47756 P47757 Cytoskeleton Cytosol SYNAPSIN P17600 O88935 Vesicle Vesicles 0 Binding 9463375 PROFILIN P47756 P47757 Cytoskeleton Cytosol DYNAMIN Q05193 P09922 GTPase Vesicles 0 Binding 9463375 SRC P12931 P05480 Kinase Cytosol CAS P56945 Q61140 Adapter Cytosol + Phosphorylation 8070403 CRK P46108 Q64010 Adapter Cytosol CAS P56945 Q61140 Adapter Cytosol 0 Binding 8070403 CRK P46108 Q64010 Adapter Cytosol C3G Q13905 P27671 GEF Cytosol + Binding 9560161 C3G Q13905 P27671 GEF Cytosol RAP1 P10113 P10113 GTPase Cytosol + GEF 9560161 C3G Q13905 P27671 GEF Cytosol RAP1 P10113 P10113 GTPase Cytosol + GEF 8524240 RAP1 P10113 P10113 GTPase Cytosol bRAF P15056 Q99N57 Kinase Cytosol + Binding 9560161 RAP1 P10113 P10113 GTPase Cytosol bRAF P15056 Q99N57 Kinase Cytosol + Binding 12446733 PAK Q13153 O88643 Kinase Cytosol ABL P00519 P00520 Kinase Cytosol + Phosphorylation 11121037 NCK P16333 Q60631 Adapter Cytosol ABL P00519 P00520 Kinase Cytosol + Phosphorylation 10488144 IRS1 P35568 P35569 Adapter Cytosol GRB2 P62993 Q60631 Adapter Cytosol + Binding 8196603 ADENOSINE NA NA Ligand Extracellular A1R P30542 Q60612 Receptor Membrane + Binding 6162091 A1R P30542 Q60612 Receptor Membrane GALPHAI P08754 Q9DC51 Gprotein Cytosol + Binding 6162091 A1R P30542 Q60612 Receptor Membrane GALPHAI P08754 Q9DC51 Gprotein Cytosol + Binding 3805010 A1R P30542 Q60612 Receptor Membrane GALPHAI P08754 Q9DC51 Gprotein Cytosol + Binding 6305455 A1R P30542 Q60612 Receptor Membrane GBETAGAMMA P11016 P11016 Gprotein Cytosol + Binding 6162091 ABL P00519 P00520 Kinase Cytosol VAV P52735 Q60992 GEF Cytosol + Phosphorylation 11790798 VAV P52735 Q60992 GEF Cytosol RAC P15154 P15154 GTPase Cytosol + GEF 11790798 ALPHA1AR P35348 P97718 Receptor Membrane GBETAGAMMA P11016 P11016 Gprotein Cytosol + Binding 1334487 ALPHA2AR P08913 Q01338 Receptor Membrane GBETAGAMMA P11016 P11016 Gprotein Cytosol + Binding 1849000 ALPHA1AR P35348 P97718 Receptor Membrane GALPHAQ P50148 P21279 Gprotein Cytosol + Binding 1334487 ALPHA1AR P35348 P97718 Receptor Membrane GALPHA11 P29992 P21279 Gprotein Cytosol + Binding 1334487 ALPHA2AR P08913 Q01338 Receptor Membrane GALPHAI P08754 Q9DC51 Gprotein Cytosol + Binding 1849000 ALPHA2AR P08913 Q01338 Receptor Membrane GALPHAO P09471 P18872 Gprotein Cytosol + Binding 1849000 PKC P17252 P05697 Kinase Cytosol ABL P00519 P00520 Kinase Cytosol + Phosphorylation 10713049 ABL P00519 P00520 Kinase Cytosol P53 Q12888 P70399 TF Nucleus + Binding 10629029 MEK2 Q9Y2U5 Q61083 Kinase Cytosol MAPK P28482 P27703 Kinase Cytosol + Phosphorylation 8226933 bRAF P15056 Q99N57 Kinase Cytosol MEK1 Q92918 Q8BPM2 Kinase Cytosol + Phosphorylation 7731720 bRAF P15056 Q99N57 Kinase Cytosol MEK1 Q92918 Q8BPM2 Kinase Cytosol + Phosphorylation 8073291 bRAF P15056 Q99N57 Kinase Cytosol MEK1 Q92918 Q8BPM2 Kinase Cytosol + Phosphorylation 1748651 bRAF P15056 Q99N57 Kinase Cytosol MEK1 Q92918 Q8BPM2 Kinase Cytosol + Phosphorylation 3043188 bRAF P15056 Q99N57 Kinase Cytosol MEK1 Q92918 Q8BPM2 Kinase Cytosol + Phosphorylation 8385802 P1433 Q04917 P11576 Adapter Cytosol bRAF P15056 Q99N57 Kinase Cytosol + Binding 7744815 P1433 Q04917 P11576 Adapter Cytosol bRAF P15056 Q99N57 Kinase Cytosol + Binding 8085159 P1433 Q04917 P11576 Adapter Cytosol bRAF P15056 Q99N57 Kinase Cytosol + Binding 8085158 RAP1 P10113 P10113 GTPase Cytosol RAF1 P04049 Q99N57 Kinase Cytosol _ Binding 12873387 RAP1 P10113 P10113 GTPase Cytosol RAF1 P04049 Q99N57 Kinase Cytosol _ Binding 12446733 PKB P31749 Q60823 Kinase Cytosol RAF1 P04049 Q99N57 Kinase Cytosol _ Phosphorylation 10576742 RAS P01111 P08556 GTPase Cytosol RAF1 P04049 Q99N57 Kinase Cytosol + Binding 7811320 RAS P01111 P08556 GTPase Cytosol RAF1 P04049 Q99N57 Kinase Cytosol + Binding 8636091 CALCINEURIN P06705 P61023 Phosphatase Cytosol AKAP P24588 Q9JL25 Adapter Cytosol 0 Binding 8599116 CALCINEURIN P06705 P61023 Phosphatase Cytosol NOS P29475 Q9Z0J4 Synthase Cytosol + Dephosphorylation 7694293 PKC P17252 P05697 Kinase Cytosol AKAP P24588 Q9JL25 Adapter Cytosol 0 Binding 8599116 PKC P17252 P05697 Kinase Cytosol AKAP P24588 Q9JL25 Adapter Cytosol 0 Binding 12359152 PKA P17612 P05132 Kinase Cytosol AKAP P24588 Q9JL25 Adapter Cytosol 0 Binding 8599116 PKA P17612 P05132 Kinase Cytosol AKAP P24588 Q9JL25 Adapter Cytosol 0 Binding 1512224 PKA P17612 P05132 Kinase Cytosol RAF1 P04049 Q99N57 Kinase Cytosol _ Phosphorylation 10862777 PKA P17612 P05132 Kinase Cytosol RAF1 P04049 Q99N57 Kinase Cytosol _ Phosphorylation 7935389 PKC P17252 P05697 Kinase Cytosol RAF1 P04049 Q99N57 Kinase Cytosol + Phosphorylation 7935389 LCK P06239 P08103 Kinase Cytosol RAF1 P04049 Q99N57 Kinase Cytosol + Phosphorylation 7935389 PKA P17612 P05132 Kinase Cytosol RAP1 P10113 P10113 GTPase Cytosol _ Phosphorylation 9867809 RAP1 P10113 P10113 GTPase Cytosol RAF1 P04049 Q99N57 Kinase Cytosol _ Binding 9867809 RAS P01111 P08556 GTPase Cytosol RAF1 P04049 Q99N57 Kinase Cytosol + Binding 9867809 PKA P17612 P05132 Kinase Cytosol CAMKK Q96RP1 Q9R054 Kinase Cytosol _ Phosphorylation 10187789 CAMKK Q96RP1 Q9R054 Kinase Cytosol CAMKI Q14012 Q91YS8 Kinase Cytosol + Phosphorylation 10187789 CALMODULIN P62158 P62204 Activator Cytosol CAMKK Q96RP1 Q9R054 Kinase Cytosol + Binding 10187789 pGC Q02153 Q9ERL9 Cyclase Cytosol CGMP NA NA Messenger Cytosol + Synthesis 7908417 pGC Q02153 Q9ERL9 Cyclase Cytosol CGMP NA NA Messenger Cytosol + Synthesis 4982201 CGMP NA NA Messenger Cytosol PKG Q13237 Q9Z0Z0 Kinase Cytosol + Binding 7908417 CGMP NA NA Messenger Cytosol PKG Q13237 Q9Z0Z0 Kinase Cytosol + Binding 5445796 CGMP NA NA Messenger Cytosol PKG Q13237 Q9Z0Z0 Kinase Cytosol + Binding 4331636 SPINOPHILIN O35274 Q99NH2 Cytoskeleton Cytosol PP1 P36873 P37139 Phosphatase Cytosol + Binding 9275233 CAMKII Q9UQM7 P11798 Kinase Cytosol CREB P16220 Q01147 TF Nucleus + Phosphorylation 1646483 CAMKI Q14012 Q91YS8 Kinase Cytosol CREB P16220 Q01147 TF Nucleus + Phosphorylation 1646483 CAMKII Q9UQM7 P11798 Kinase Cytosol SPINOPHILIN O35274 Q99NH2 Cytoskeleton Cytosol _ Phosphorylation 15228588 SPINOPHILIN O35274 Q99NH2 Cytoskeleton Cytosol ACTIN P60712 P60711 Cytoskeleton Cytosol 0 Binding 15228588 PKA P17612 P05132 Kinase Cytosol SPINOPHILIN O35274 Q99NH2 Cytoskeleton Cytosol + Phosphorylation 12417592 SPINOPHILIN O35274 Q99NH2 Cytoskeleton Cytosol ACTIN P60712 P60711 Cytoskeleton Cytosol 0 Binding 12417592 SPINOPHILIN O35274 Q99NH2 Cytoskeleton Cytosol ACTIN P60712 P60711 Cytoskeleton Cytosol 0 Binding 9452470 SPINOPHILIN O35274 Q99NH2 Cytoskeleton Cytosol PP1 P36873 P37139 Phosphatase Cytosol + Binding 12417592 MP1 Q9UHA4 O88653 Adapter Cytosol MEK1 Q92918 Q8BPM2 Kinase Cytosol + Binding 9733512 MP1 Q9UHA4 O88653 Adapter Cytosol MAPK P28482 P27703 Kinase Cytosol + Binding 9733512 JIP Q9UQF2 Q9WVI9 Adapter Cytosol JNK P45983 Q91Y86 Kinase Nucleus _ Binding 9235893 JIP Q9UQF2 Q9WVI9 Adapter Cytosol JNK P45983 Q91Y86 Kinase Nucleus _ Binding 10490659 NIK Q99558 Q9WUL6 Kinase Cytosol MEKK1 Q13233 P53349 Kinase Cytosol + Binding 9135144 NIK Q99558 Q9WUL6 Kinase Cytosol NCK P16333 Q60631 Adapter Cytosol + Binding 9135144 JIP Q9UQF2 Q9WVI9 Adapter Cytosol MLK3 Q02779 Q60700 Kinase Cytosol + Binding 9733513 JIP Q9UQF2 Q9WVI9 Adapter Cytosol MEK7 O14733 P47809 Kinase Cytosol + Binding 9733513 JIP Q9UQF2 Q9WVI9 Adapter Cytosol DLK P80370 Q9JI71 Kinase Cytosol + Binding 9733513 MEKK3 Q99759 Q61084 Kinase Cytosol MEK3 Q8IVH8 Q8BPM2 Kinase Cytosol + Phosphorylation 9162092 MEKK2 Q9Y2U5 Q61083 Kinase Cytosol MEK4 P45985 P47809 Kinase Cytosol + Phosphorylation 9162092 MEKK4 Q9Y6R4 NA Kinase Cytosol MEK3 Q8IVH8 Q8BPM2 Kinase Cytosol + Phosphorylation 9305639 MEKK4 Q9Y6R4 NA Kinase Cytosol MEK6 Q8N4C8 Q8N4C8 Kinase Cytosol + Phosphorylation 9305639 PKC P17252 P05697 Kinase Cytosol CPI17 Q96A00 Q91VC7 Inhibitor Cytosol + Phosphorylation 15003508 PKC P17252 P05697 Kinase Cytosol CPI17 Q96A00 Q91VC7 Inhibitor Cytosol + Phosphorylation 12495628 CPI17 Q96A00 Q91VC7 Inhibitor Cytosol MYOSINPPASE O60237 Q8BG95 Phosphatase Cytosol _ Binding 12495628 PKN Q16512 P70268 Kinase Cytosol CPI17 Q96A00 Q91VC7 Inhibitor Cytosol + Phosphorylation 10924361 CASK Q9HCP0 Q8BTH8 Kinase Cytosol CPI17 Q96A00 Q91VC7 Inhibitor Cytosol 0 Binding 15003508 ILK Q13418 O55222 Kinase Cytosol CPI17 Q96A00 Q91VC7 Inhibitor Cytosol + Phosphorylation 12144526 ROCK O75116 P70336 Kinase Cytosol CPI17 Q96A00 Q91VC7 Inhibitor Cytosol + Phosphorylation 10869555 VDAC2 P45880 Q60930 Channel Mitochondria BAK Q16611 NA Bcl2Family Mitochondria _ Binding 12881569 BCLXL Q07817 P70345 Bcl2Family Mitochondria BAX Q07812 Q07813 Bcl2Family Mitochondria _ Binding 8596636 JNK P45983 Q91Y86 Kinase Nucleus BIM O43521 O54918 Bcl2Family Mitochondria + Phosphorylation 12818176 BCL2 P10415 Q64373 Bcl2Family Mitochondria BAX Q07812 Q07813 Bcl2Family Mitochondria _ Binding 8358790 BIM O43521 O54918 Bcl2Family Mitochondria BAX Q07812 Q07813 Bcl2Family Mitochondria + Binding 11301022 BIM O43521 O54918 Bcl2Family Mitochondria BCL2 P10415 Q64373 Bcl2Family Mitochondria _ Binding 11301022 JNK P45983 Q91Y86 Kinase Nucleus ELK1 P19419 P41969 TF Nucleus + Phosphorylation 8846788 JNK P45983 Q91Y86 Kinase Nucleus ELK1 P19419 P41969 TF Nucleus + Phosphorylation 9501095 P38 Q16539 P47811 Kinase Cytosol ATF2 P15336 Q60765 TF Nucleus + Phosphorylation 8663524 MEK3 Q8IVH8 Q8BPM2 Kinase Cytosol P38 Q16539 P47811 Kinase Cytosol + Phosphorylation 8622669 MEK6 Q8N4C8 Q8N4C8 Kinase Cytosol P38 Q16539 P47811 Kinase Cytosol + Phosphorylation 8622669 P38 Q16539 P47811 Kinase Cytosol ELK1 P19419 P41969 TF Nucleus + Phosphorylation 8622669 P38 Q16539 P47811 Kinase Cytosol MEF2 Q02080 O55087 TF Nucleus + Phosphorylation 10531066 ARH2 Q92974 P97433 GEF Cytosol RAC P15154 P15154 GTPase Cytosol + GEF 9857026 ARH2 Q92974 P97433 Adapter Cytosol RHO Q07960 Q8C0D4 GTPase Cytosol + GEF 9857026 TUBULIN P05209 P05209 Cytoskeleton Cytosol ARH2 Q92974 P97433 Adapter Cytosol 0 Binding 9857026 JIP Q9UQF2 Q9WVI9 Adapter Cytosol RHOGEF Q92888 Q8R4H2 GEF Cytosol 0 Binding 10574993 JIP Q9UQF2 Q9WVI9 Adapter Cytosol MEK4 P45985 P47809 Kinase Cytosol + Binding 9733513 MEK7 O14733 P47809 Kinase Cytosol JNK P45983 Q91Y86 Kinase Nucleus + Phosphorylation 9733513 BETAARRESTIN P49407 Q91YI4 Adapter Cytosol FRIZZLED Q9UP38 O70421 Receptor Membrane + Binding 11742073 CASK Q9HCP0 Q8BTH8 Kinase Cytosol DISHEVELED O14640 P51141 Adapter Membrane + Phosphorylation 9214626 CASK Q9HCP0 Q8BTH8 Kinase Cytosol DISHEVELED O14640 P51141 Adapter Membrane + Phosphorylation 10409711 CASK Q9HCP0 Q8BTH8 Kinase Cytosol DISHEVELED O14640 P51141 Adapter Membrane + Phosphorylation 10806215 DISHEVELED O14640 P51141 Adapter Membrane PAR1 P25116 P30558 Adapter Cytosol + Binding 11433294 BETAARRESTIN P49407 Q91YI4 Adapter Cytosol SRC P12931 P05480 Kinase Cytosol + Binding 10753943 SRC P12931 P05480 Kinase Cytosol SAM68 Q8TCZ4 Q64213 Adapter Cytosol + Phosphorylation 7537265 SRC P12931 P05480 Kinase Cytosol SAM68 Q8TCZ4 Q64213 Adapter Cytosol + Phosphorylation 7512695 PDZGEF Q9Y4G8 Q8CHG7 GEF Cytosol RAP1 P10113 P10113 GTPase Cytosol + GEF 10608883 PDZGEF Q9Y4G8 Q8CHG7 GEF Cytosol RAP2 P10114 Q8BU31 GTPase Cytosol + GEF 10608883 CALMODULIN P62158 P62204 Activator Cytosol RAB3 P20336 P05713 GTPase Vesicles _ Binding 9252412 CALCIUM NA NA Messenger Cytosol SYNAPTOTAGMIN P21579 P46096 Vesicle Vesicles + Binding 1589771 CALCIUM NA NA Messenger Cytosol DYNAMIN Q05193 P09922 GTPase Vesicles + Binding 8063723 PKC P17252 P05697 Kinase Cytosol DYNAMIN Q05193 P09922 GTPase Vesicles _ Phosphorylation 8063723 PKC P17252 P05697 Kinase Cytosol MARCKS P29966 P26645 Adapter Cytosol _ Phosphorylation 6957862 PKC P17252 P05697 Kinase Cytosol MARCKS P29966 P26645 Adapter Cytosol _ Phosphorylation 15316066 PKC P17252 P05697 Kinase Cytosol GAP43 P17677 P06837 Adapter Cytosol + Phosphorylation 7891109 PKC P17252 P05697 Kinase Cytosol GAP43 P17677 P06837 Adapter Cytosol + Phosphorylation 2562806 RABGDI P31150 P50396 Inhibitor Cytosol RAB3 P20336 P05713 GTPase Vesicles _ Binding 9252412 PKC P17252 P05697 Kinase Cytosol AC2 Q08462 Q91WF3 Cyclase Cytosol + Phosphorylation 8383119 PKC P17252 P05697 Kinase Cytosol AC2 Q08462 Q91WF3 Cyclase Cytosol + Phosphorylation 9268695 PKC P17252 P05697 Kinase Cytosol AC2 Q08462 Q91WF3 Cyclase Cytosol + Phosphorylation 9366262 PKC P17252 P05697 Kinase Cytosol AC2 Q08462 Q91WF3 Cyclase Cytosol + Phosphorylation 7938004 PKC P17252 P05697 Kinase Cytosol AC2 Q08462 Q91WF3 Cyclase Cytosol + Phosphorylation 8900209 GALPHAS P04895 P04894 Gprotein Cytosol AC1 Q08828 Q01341 Cyclase Cytosol + Binding 210183 GALPHAS P04895 P04894 Gprotein Cytosol AC1 Q08828 Q01341 Cyclase Cytosol + Binding 6935665 GALPHAS P04895 P04894 Gprotein Cytosol AC1 Q08828 Q01341 Cyclase Cytosol + Binding 2022671 AC5 O95622 Q01341 Cyclase Membrane CAMP NA NA Messenger Cytosol + Synthesis 1618857 PKC P17252 P05697 Kinase Cytosol AC5 O95622 Q01341 Cyclase Membrane + Phosphorylation 8206971 GALPHAS P04895 P04894 Gprotein Cytosol AC5 O95622 Q01341 Cyclase Membrane + Binding 9748257 NO NA NA Messenger Cytosol pGC Q02153 Q9ERL9 Cyclase Cytosol + Binding 20623 NO NA NA Messenger Cytosol pGC Q02153 Q9ERL9 Cyclase Cytosol + Binding 2903071 GALPHAS P04895 P04894 Gprotein Cytosol AC2 Q08462 Q91WF3 Cyclase Cytosol + Binding 1719547 GALPHAS P04895 P04894 Gprotein Cytosol AC2 Q08462 Q91WF3 Cyclase Cytosol + Binding 9395396 AC1 Q08828 Q01341 Cyclase Cytosol CAMP NA NA Messenger Cytosol + Synthesis 2022671 AC2 Q08462 Q91WF3 Cyclase Cytosol CAMP NA NA Messenger Cytosol + Binding 1719547 BETA2AR P07550 P18762 Receptor Membrane GALPHAS P04895 P04894 Gprotein Cytosol + Binding 6149763 BETA2AR P07550 P18762 Receptor Membrane GBETAGAMMA P11016 P11016 Gprotein Cytosol + Binding 6149763 SEROTONIN NA NA Ligand Extracellular FIVEHT1CR P28335 P34968 Receptor Membrane + Binding 3473504 SEROTONIN NA NA Ligand Extracellular FIVEHT1CR P28335 P34968 Receptor Membrane + Binding 3399891 RHEB Q15382 Q921J2 Adapter Cytosol RAF1 P04049 Q99N57 Kinase Cytosol + Binding 9001246 PKA P17612 P05132 Kinase Cytosol RAF1 P04049 Q99N57 Kinase Cytosol _ Phosphorylation 9001246 RAS P01111 P08556 GTPase Cytosol RAF1 P04049 Q99N57 Kinase Cytosol + Binding 9001246 EGFR P00533 Q01279 Receptor Membrane GRB2 P62993 Q60631 Adapter Cytosol + Binding 8479540 EGFR P00533 Q01279 Receptor Membrane GRB2 P62993 Q60631 Adapter Cytosol + Binding 1322798 PYK2 Q14289 Q60629 Kinase Cytosol GRB2 P62993 Q60631 Adapter Cytosol + Binding 10329689 PYK2 Q14289 Q60629 Kinase Cytosol GRB2 P62993 Q60631 Adapter Cytosol + Binding 9560226 PYK2 Q14289 Q60629 Kinase Cytosol SRC P12931 P05480 Kinase Cytosol + Binding 9560226 PYK2 Q14289 Q60629 Kinase Cytosol KV12 P16389 P15386 Channel Membrane _ Phosphorylation 7544443 PYK2 Q14289 Q60629 Kinase Cytosol KV12 P16389 P15386 Channel Membrane _ Phosphorylation 9560226 KV12 P16389 P15386 Channel Membrane POTASSIUM NA NA Ion Cytosol + Opening 2555158 SYNTAXIN Q13277 O35526 Vesicle Vesicles KV11 Q09470 P16388 Channel Membrane + Binding 12114518 GBETAGAMMA P11016 P11016 Gprotein Cytosol KV11 Q09470 P16388 Channel Membrane + Binding 12114518 KV11 Q09470 P16388 Channel Membrane POTASSIUM NA NA Ion Cytosol + Opening 2451788 SYNTAXIN Q13277 O35526 Vesicle Vesicles NTYPECA Q00975 P97445 Channel Membrane _ Binding 10692440 SYNTAXIN Q13277 O35526 Vesicle Vesicles NTYPECA Q00975 P97445 Channel Membrane _ Binding 7993624 GBETAGAMMA P11016 P11016 Gprotein Cytosol SYNTAXIN Q13277 O35526 Vesicle Vesicles + Binding 10692440 SYNTAXIN Q13277 O35526 Vesicle Vesicles MUNC18 P61763 P61765 Vesicle Vesicles 0 Binding 15175344 SYNAPTOTAGMIN P21579 P46096 Vesicle Vesicles LTYPECA Q13936 Q13936 Channel Membrane + Binding 12645522 SYNAPTOTAGMIN P21579 P46096 Vesicle Vesicles RTYPECA Q15878 Q61290 Channel Membrane + Binding 12645522 RTYPECA Q15878 Q61290 Channel Membrane CALCIUM NA NA Messenger Cytosol + Opening 8071363 CALMODULIN P62158 P62204 Activator Cytosol MUNC13 O14795 Q9Z1N9 Vesicle Vesicles + Binding 15294163 CALMODULIN P62158 P62204 Activator Cytosol MUNC13 O14795 Q9Z1N9 Vesicle Vesicles + Binding 12917685 MUNC18 P61763 P61765 Vesicle Vesicles MINT Q02410 P98084 Vesicle Vesicles 0 Binding 9395480 MINT Q02410 P98084 Vesicle Vesicles CASK Q9HCP0 Q8BTH8 Kinase Cytosol 0 Binding 12040031 CASKIN Q8WXD9 Q8VHK1 Vesicle Vesicles CASK Q9HCP0 Q8BTH8 Kinase Cytosol 0 Binding 12040031 CASK Q9HCP0 Q8BTH8 Kinase Cytosol TBR1 Q16650 Q64336 TF Nucleus + Binding 10749215 CASK Q9HCP0 Q8BTH8 Kinase Cytosol PMCA P20020 Q9R0K7 Pump Membrane + Binding 12511555 SHPTP2 Q06124 P29351 Phosphatase Cytosol GRB2 P62993 Q60631 Adapter Cytosol + Binding 7523381 PDGFR P09619 P05622 Receptor Membrane SHPTP2 Q06124 P29351 Phosphatase Cytosol + Binding 8226787 PDGFR P09619 P05622 Receptor Membrane SHPTP2 Q06124 P29351 Phosphatase Cytosol + Binding 7688466 PDGFR P09619 P05622 Receptor Membrane APS O14492 Q9JID9 Adapter Cytosol + Binding 9989826 PDGF NA NA Ligand Extracellular PDGFR P09619 P05622 Receptor Membrane + Binding 2550144 PDGFR P09619 P05622 Receptor Membrane NHERF O14745 P70441 Adapter Cytosol 0 Binding 11882663 BETA2AR P07550 P18762 Receptor Membrane NHERF O14745 P70441 Adapter Cytosol 0 Binding 11882663 RACK P25388 P25388 Adapter Cytosol PKC P17252 P05697 Kinase Cytosol 0 Binding 11956211 RACK P25388 P25388 Adapter Cytosol PKC P17252 P05697 Kinase Cytosol 0 Binding 1831196 RACK P25388 P25388 Adapter Cytosol PKC P17252 P05697 Kinase Cytosol 0 Binding 7831317 RACK P25388 P25388 Adapter Cytosol NHERF O14745 P70441 Adapter Cytosol 0 Binding 11956211 RYR P21817 Q80X16 Channel ER CALCIUM NA NA Messenger Cytosol + Opening 2445748 SHPTP2 Q06124 P29351 Phosphatase Cytosol GAB1 Q13480 Q9QYY0 Adapter Cytosol _ Dephosphorylation 14701753 SHPTP2 Q06124 P29351 Phosphatase Cytosol SPROUTY O43609 Q9QXV9 Adapter Cytosol _ Dephosphorylation 15031289 GRB2 P62993 Q60631 Adapter Cytosol SPROUTY O43609 Q9QXV9 Adapter Cytosol 0 Binding 15031289 SHPTP2 Q06124 P29351 Phosphatase Cytosol PAXILLIN P49023 Q8CI51 Adapter Cytosol _ Dephosphorylation 14665621 GAB1 Q13480 Q9QYY0 Adapter Cytosol PAXILLIN P49023 Q8CI51 Adapter Cytosol 0 Binding 14665621 CSK P41240 P00520 Kinase Cytosol PAXILLIN P49023 Q8CI51 Adapter Cytosol + Phosphorylation 9890993 CSK P41240 P00520 Kinase Cytosol FAK Q05397 Q60750 Kinase Cytosol + Phosphorylation 9890993 CSK P41240 P00520 Kinase Cytosol SRC P12931 P05480 Kinase Cytosol _ Binding 14665621 CSK P41240 P00520 Kinase Cytosol SRC P12931 P05480 Kinase Cytosol _ Binding 1383688 SHPTP2 Q06124 P29351 Phosphatase Cytosol GRB2 P62993 Q60631 Adapter Cytosol + Binding 7522233 SHPTP2 Q06124 P29351 Phosphatase Cytosol PI3K P42336 P42337 Kinase Cytosol + Binding 7522233 DENSIN Q15003 Q9JI18 Adapter Cytosol CAMKII Q9UQM7 P11798 Kinase Cytosol 0 Binding 11160423 DENSIN Q15003 Q9JI18 Adapter Cytosol CAMKII Q9UQM7 P11798 Kinase Cytosol 0 Binding 10827168 NMDAR Q12879 P35436 Receptor Membrane CAMKII Q9UQM7 P11798 Kinase Cytosol 0 Binding 12379661 CALMODULIN P62158 P62204 Activator Cytosol NMDAR Q12879 P35436 Receptor Membrane _ Binding 12379661 NMDAR Q12879 P35436 Receptor Membrane ALPHAACTININ Q08043 O88990 Cytoskeleton Cytosol 0 Binding 12379661 CAMKII Q9UQM7 P11798 Kinase Cytosol ALPHAACTININ Q08043 O88990 Cytoskeleton Cytosol 0 Binding 11160423 DENSIN Q15003 Q9JI18 Adapter Cytosol ALPHAACTININ Q08043 O88990 Cytoskeleton Cytosol 0 Binding 11160423 SEROTONIN NA NA Ligand Extracellular FIVEHT1AR P08908 Q64264 Receptor Membrane + Binding 3041227 SEROTONIN NA NA Ligand Extracellular FIVEHT1AR P08908 Q64264 Receptor Membrane + Binding 3138543 SEROTONIN NA NA Ligand Extracellular FIVEHT1AR P08908 Q64264 Receptor Membrane + Binding 2156831 SEROTONIN NA NA Ligand Extracellular FIVEHT2AR P28223 P35363 Receptor Membrane + Binding 2300586 SEROTONIN NA NA Ligand Extracellular FIVEHT2AR P28223 P35363 Receptor Membrane + Binding 1722404 SEROTONIN NA NA Ligand Extracellular FIVEHT4R Q13639 P97288 Receptor Membrane + Binding 7796807 ADENOSINE NA NA Ligand Extracellular A1R P30542 Q60612 Receptor Membrane + Binding 1646713 ADENOSINE NA NA Ligand Extracellular A1R P30542 Q60612 Receptor Membrane + Binding 1857334 ADENOSINE NA NA Ligand Extracellular A2AR P29274 Q60613 Receptor Membrane + Binding 2541503 ADENOSINE NA NA Ligand Extracellular A2AR P29274 Q60613 Receptor Membrane + Binding 2125216 A2AR P29274 Q60613 Receptor Membrane GALPHAS P04895 P04894 Gprotein Cytosol + Binding 8995267 A2AR P29274 Q60613 Receptor Membrane GALPHAS P04895 P04894 Gprotein Cytosol + Binding 6162091 A2AR P29274 Q60613 Receptor Membrane GBETAGAMMA P11016 P11016 Gprotein Cytosol + Binding 8995267 VAV P52735 Q60992 GEF Cytosol RHO Q07960 Q8C0D4 GTPase Cytosol + GEF 9822605 VAV P52735 Q60992 GEF Cytosol RHO Q07960 Q8C0D4 GTPase Cytosol + GEF 9032261 VAV P52735 Q60992 GEF Cytosol RHO Q07960 Q8C0D4 GTPase Cytosol + GEF 8994827 VAV P52735 Q60992 GEF Cytosol CDC42 P60953 P60766 GTPase Cytosol + GEF 8994827 VAV P52735 Q60992 GEF Cytosol CDC42 P60953 P60766 GTPase Cytosol + GEF 9032261 RHOGEF Q92888 Q8R4H2 GEF Cytosol RHO Q07960 Q8C0D4 GTPase Cytosol + GEF 8810315 GALPHA12 Q03113 P27601 Gprotein Cytosol RHOGEF Q92888 Q8R4H2 GEF Cytosol + Binding 9641916 GALPHA13 Q14344 P27601 Gprotein Cytosol RHOGEF Q92888 Q8R4H2 GEF Cytosol + Binding 9641916 PIP3 NA NA Lipid Membrane VAV P52735 Q60992 GEF Cytosol + Binding 9438848 ARNO Q99418 P97695 GEF Cytosol ARF P32889 P32889 GTPase Vesicles + GEF 8945478 EFA6 Q9NYI0 O08967 GEF Cytosol ARF P32889 P32889 GTPase Vesicles + GEF 11342560 BDNF P23560 P21237 Ligand Extracellular TRKB Q16620 Q9Z139 Receptor Membrane + Binding 1645620 RAP1 P10113 P10113 GTPase Cytosol bRAF P15056 Q99N57 Kinase Cytosol + Binding 9094716 RAS P01111 P08556 GTPase Cytosol bRAF P15056 Q99N57 Kinase Cytosol + Binding 7935411 PKA P17612 P05132 Kinase Cytosol bRAF P15056 Q99N57 Kinase Cytosol + Phosphorylation 10931830 D1R P21728 Q61616 Receptor Membrane GBETAGAMMA P11016 P11016 Gprotein Cytosol + Binding 1832710 M1R P11229 P12657 Receptor Membrane GBETAGAMMA P11016 P11016 Gprotein Cytosol + Binding 8196770 RAP1 P10113 P10113 GTPase Cytosol RALGDS Q12967 Q03385 GEF Cytosol + Binding 8636102 PKC P17252 P05697 Kinase Cytosol PLA2 Q9Y263 Q9Z0Y2 Phospholipase Cytosol + Phosphorylation 12423237 MAPK P28482 P27703 Kinase Cytosol PLA2 Q9Y263 Q9Z0Y2 Phospholipase Cytosol + Phosphorylation 8381049 P38 Q16539 P47811 Kinase Cytosol PLA2 Q9Y263 Q9Z0Y2 Phospholipase Cytosol + Phosphorylation 8910365 RHO Q07960 Q8C0D4 GTPase Cytosol CITRON O14578 Q02566 Kinase Cytosol + Binding 9697773 PKG Q13237 Q9Z0Z0 Kinase Cytosol NOS P29475 Q9Z0J4 Synthase Cytosol + Phosphorylation 7532810 STARGAZIN Q9BXT1 Q9BXT1 Chaperone Cytosol PSD95 P78352 Q62108 Adapter Cytosol 0 Binding 12359873 AMPAR P42261 P23818 Channel Membrane STARGAZIN Q9BXT1 Q9BXT1 Chaperone Cytosol 0 Binding 11140673 ELK1 P19419 P41969 TF Nucleus SRE NA NA DNA Nucleus + Binding 8614640 L1 P32004 P11627 CellAdhesion Membrane ANKYRIN P16157 Q02357 Cytoskeleton Cytosol 0 Binding 7961622 L1 P32004 P11627 CellAdhesion Membrane ANKYRIN P16157 Q02357 Cytoskeleton Cytosol 0 Binding 12070130 NRCAM Q92823 Q810U4 CellAdhesion Membrane ANKYRIN P16157 Q02357 Cytoskeleton Cytosol 0 Binding 7961622 FAK Q05397 Q60750 Kinase Cytosol ALPHAACTININ Q08043 O88990 Cytoskeletal Cytosol _ Phosphorylation 11369769 BRADYKININ NA NA Ligand Extracellular BR1R P46663 Q61125 Receptor Membrane + Binding 6113593 BRADYKININ NA NA Ligand Extracellular BR1R P46663 Q61125 Receptor Membrane + Binding 2907120 BR1R P46663 Q61125 Receptor Membrane GBETAGAMMA P11016 P11016 Gprotein Cytosol + Binding 1645526 BRADYKININ NA NA Ligand Extracellular BR1R P46663 Q61125 Receptor Membrane + Binding 1652448 PYK2 Q14289 Q60629 Kinase Cytosol SRC P12931 P05480 Kinase Cytosol + Binding 8849729 BR1R P46663 Q61125 Receptor Membrane GALPHAQ P50148 P21279 Gprotein Cytosol + Binding 11713280 BR1R P46663 Q61125 Receptor Membrane GBETAGAMMA P11016 P11016 Gprotein Cytosol + Binding 11713280 BR1R P46663 Q61125 Receptor Membrane GALPHAI P08754 Q9DC51 Gprotein Cytosol + Binding 11713280 BR1R P46663 Q61125 Receptor Membrane GALPHA11 P29992 P21279 Gprotein Cytosol + Binding 11379050 BR1R P46663 Q61125 Receptor Membrane GALPHAQ P50148 P21279 Gprotein Cytosol + Binding 11379050 DAG NA NA Lipid Cytosol RASGRP Q8IV61 Q91ZC8 GAP Cytosol + Binding 9582122 CALCIUM NA NA Messenger Cytosol RASGRP Q8IV61 Q91ZC8 GAP Cytosol + Binding 9582122 RASGRF Q13972 P27671 GEF Cytosol RAS P01111 P08556 GTPase Cytosol + GEF 7828890 RASGRF Q13972 P27671 GEF Cytosol RAC P15154 P15154 GTPase Cytosol + GEF 10220378 CAMKII Q9UQM7 P11798 Kinase Cytosol RASGRF Q13972 P27671 GEF Cytosol + Phosphorylation 9281359 CALMODULIN P62158 P62204 Activator Cytosol IP3R Q14643 P11881 Channel ER _ Binding 10456332 RASGRP Q8IV61 Q91ZC8 GAP Cytosol RAS P01111 P08556 GTPase Cytosol + GEF 9582122 PKC P17252 P05697 Kinase Cytosol RASGRP Q8IV61 Q91ZC8 GAP Cytosol + Phosphorylation 15213298 NMDAR Q12879 P35436 Receptor Membrane RASGRF Q13972 P27671 GEF Cytosol 0 Binding 14622581 RASGRF Q13972 P27671 GEF Cytosol RAS P01111 P08556 GTPase Cytosol + GEF 9430727 RASGRF Q13972 P27671 GEF Cytosol RAS P01111 P08556 GTPase Cytosol + GEF 11560935 MKP5 Q9Y6W6 Q9ESS0 Phosphatase Cytosol P38 Q16539 P47811 Kinase Cytosol _ Dephosphorylation 11790549 MKP5 Q9Y6W6 Q9ESS0 Phosphatase Cytosol JNK P45983 Q91Y86 Kinase Nucleus _ Dephosphorylation 11790549 RASGRF Q13972 P27671 GEF Cytosol RAS P01111 P08556 GTPase Cytosol + GEF 9379834 CALCIUM NA NA Messenger Cytosol CAPRI O43374 Q91ZC8 GAP Cytosol + Binding 11448776 CALCIUM NA NA Messenger Cytosol CAPRI O43374 Q91ZC8 GAP Cytosol + Binding 12845332 CAPRI O43374 Q91ZC8 GAP Cytosol RAS P01111 P08556 GTPase Cytosol _ GAP 11448776 CAPRI O43374 Q91ZC8 GAP Cytosol RAS P01111 P08556 GTPase Cytosol _ GAP 12845332 RASGRF Q13972 P27671 GEF Cytosol RAS P01111 P08556 GTPase Cytosol + GEF 9032266 RASGRF Q13972 P27671 GEF Cytosol RAS P01111 P08556 GTPase Cytosol + GEF 1379346 RASGRF Q13972 P27671 GEF Cytosol RAC P15154 P15154 GTPase Cytosol + GEF 10544264 CALMODULIN P62158 P62204 Activator Cytosol RASGRF Q13972 P27671 GEF Cytosol + Binding 7637786 CALMODULIN P62158 P62204 Activator Cytosol RASGRF Q13972 P27671 GEF Cytosol + Binding 8756648 CAMP NA NA Messenger Cytosol EPAC O95398 Q8VCC8 GEF Cytosol + Binding 12888551 CAMP NA NA Messenger Cytosol EPAC O95398 Q8VCC8 GEF Cytosol + Binding 9853756 EPAC O95398 Q8VCC8 GEF Cytosol RAP1 P10113 P10113 GTPase Cytosol + GEF 9853756 CALMODULIN P62158 P62204 Activator Cytosol RIN1 Q13671 Q921Q7 Activator Cytosol + Binding 8824319 RIN1 Q13671 Q921Q7 Activator Cytosol RAS P01111 P08556 GTPase Cytosol _ Binding 12574403 P1433 Q04917 P11576 Adapter Cytosol RIN1 Q13671 Q921Q7 Activator Cytosol _ Binding 11784866 RIN1 Q13671 Q921Q7 Activator Cytosol RAS P01111 P08556 GTPase Cytosol _ Binding 11784866 PKD Q15139 Q62101 Kinase Cytosol P1433 Q04917 P11576 Adapter Cytosol + Phosphorylation 11784866 GLYCINE NA NA Ligand Extracellular GLYR P23415 Q61603 Receptor Membrane + Binding 2998565 PKA P17612 P05132 Kinase Cytosol GLYR P23415 Q61603 Receptor Membrane + Phosphorylation 8294452 PKC P17252 P05697 Kinase Cytosol GLYR P23415 Q61603 Receptor Membrane _ Phosphorylation 8294452 SRC P12931 P05480 Kinase Cytosol GLYR P23415 Q61603 Receptor Membrane + Phosphorylation 11882681 SRC P12931 P05480 Kinase Cytosol GABAAR P14867 P18504 Receptor Membrane + Phosphorylation 7566089 BID P55957 P70444 Bcl2Family Cytosol BAX Q07812 Q07813 Bcl2Family Mitochondria + Binding 8918887 TRKB Q16620 Q9Z139 Receptor Membrane SHC P29353 Q61120 Adapter Cytosol + Binding 8808684 EGFR P00533 Q01279 Receptor Membrane SHC P29353 Q61120 Adapter Cytosol + Binding 8808684 SHC P29353 Q61120 Adapter Cytosol GRB2 P62993 Q60631 Adapter Cytosol 0 Binding 8808684 GSK3 P49840 Q9WV60 Kinase Cytosol CREB P16220 Q01147 TF Nucleus + Phosphorylation 7798217 PKB P31749 Q60823 Kinase Cytosol GSK3 P49840 Q9WV60 Kinase Cytosol _ Phosphorylation 8524413 PP2A Q13362 Q80W65 Phosphatase Cytosol GSK3 P49840 Q9WV60 Kinase Cytosol + Dephosphorylation 8524413 SHP1 Q96B97 Q9JLQ0 Phosphatase Cytosol JAK O60674 Q62120 Kinase Cytosol + Dephosphorylation 8943354 AP2 P53680 P61966 Adapter Vesicles SYNAPTOTAGMIN P21579 P46096 Vesicle Vesicles 0 Binding 8087843 GALPHA13 Q14344 P27601 Gprotein Cytosol RADIXIN P35241 P26041 Adapter Cytosol + Binding 10816569 RADIXIN P35241 P26041 Adapter Cytosol ACTIN P60712 P60711 Cytoskeleton Cytosol 0 Binding 10816569 PKA P17612 P05132 Kinase Cytosol RAP1 P10113 P10113 GTPase Cytosol _ Phosphorylation 8463283 PAFR P25105 Q62035 Receptor Membrane GALPHAI P08754 Q9DC51 Gprotein Cytosol + Binding 8858930 CAMKIV Q16566 P08414 Kinase Cytosol CREM Q03060 Q01147 TF Nucleus + Phosphorylation 7799965 CAMKIV Q16566 P08414 Kinase Cytosol CREM Q03060 Q01147 TF Nucleus + Phosphorylation 8523736 AXIN O15169 O88566 Adapter Cytosol APC Q9H1A4 P53995 Adapter Cytosol 0 Binding 9734785 ANP NA NA Ligand Extracellular pGC Q02153 Q9ERL9 Cyclase Membrane + Binding 2571188 NWASP Q92558 P42337 Activator Cytosol ARP23 O15143 Q9WV32 Cytoskeleton Cytosol + Binding 10781580 NWASP Q92558 P42337 Activator Cytosol NIK Q99558 Q9WUL6 Kinase Cytosol 0 Binding 7565724 ARP23 O15143 Q9WV32 Cytoskeleton Cytosol ACTIN P60712 P60711 Cytoskeleton Cytosol + Binding 9600938 IKBB Q15653 O54910 Adapter Cytosol NFKB P19838 P25799 TF Nucleus _ Binding 8816457 IGF1 P01343 P05018 Ligand Extracellular IGF1R P08069 Q60751 Receptor Cytosol + Binding 8408032 PKG Q13237 Q9Z0Z0 Kinase Cytosol ADPRIBSYCYCLASE P28907 Q64277 Synthase Cytosol + Phosphorylation 8663443 M1R P11229 P12657 Receptor Membrane GALPHA11 P29992 P21279 Gprotein Cytosol + Binding 14976183 M1R P11229 P12657 Receptor Membrane RGS2 P41220 O08849 Gprotein Cytosol 0 Binding 14976183 RGS2 P41220 O08849 Gprotein Cytosol GALPHA11 P29992 P21279 Gprotein Cytosol _ GAP 14976183 RGS2 P41220 O08849 Gprotein Cytosol GALPHAQ P50148 P21279 Gprotein Cytosol _ GAP 14976183 M1R P11229 P12657 Receptor Membrane GBETAGAMMA P11016 P11016 Gprotein Cytosol + Binding 14976183 RGS2 P41220 O08849 Gprotein Cytosol GALPHAI P08754 Q9DC51 Gprotein Cytosol _ GAP 9736641 RGS2 P41220 O08849 Gprotein Cytosol GALPHAQ P50148 P21279 Gprotein Cytosol _ GAP 9736641 M2R P08172 Q9ERZ4 Receptor Membrane RGS2 P41220 O08849 Gprotein Cytosol 0 Binding 9736641 EGF NA NA Ligand Extracellular EGFR P00533 Q01279 Receptor Membrane + Binding 11331309 MAPK P28482 P27703 Kinase Cytosol KV42 Q9NZV8 Q9Z0V2 Channel Membrane + Phosphorylation 12077183 MAPK P28482 P27703 Kinase Cytosol KV42 Q9NZV8 Q9Z0V2 Channel Membrane + Phosphorylation 11080179 KV42 Q9NZV8 Q9Z0V2 Channel Membrane POTASSIUM NA NA Ion Cytosol + Opening 10551270 IGF1R P08069 Q60751 Receptor Cytosol VAV P52735 Q60992 GEF Cytosol + Phosphorylation 11094073 KV42 Q9NZV8 Q9Z0V2 Channel Membrane POTASSIUM NA NA Ion Cytosol + Opening 15269337 P38 Q16539 P47811 Kinase Cytosol STAT P42224 P42227 TF Nucleus + Phosphorylation 10201984 AXIN O15169 O88566 Adapter Cytosol GSK3 P49840 Q9WV60 Kinase Cytosol + Binding 10196136 AXIN O15169 O88566 Adapter Cytosol BETACATENIN P35222 Q02248 TF Cytosol _ Binding 10196136 AXIN O15169 O88566 Adapter Cytosol GSK3 P49840 Q9WV60 Kinase Cytosol + Binding 9482734 AXIN O15169 O88566 Adapter Cytosol BETACATENIN P35222 Q02248 TF Cytosol _ Binding 9482734 GSK3 P49840 Q9WV60 Kinase Cytosol BETACATENIN P35222 Q02248 TF Cytosol _ Phosphorylation 9482734 AXIN O15169 O88566 Adapter Cytosol APC Q9H1A4 P53995 Adapter Cytosol 0 Binding 9556553 APC Q9H1A4 P53995 Adapter Cytosol BETACATENIN P35222 Q02248 TF Cytosol _ Binding 9556553 AXIN O15169 O88566 Adapter Cytosol GSK3 P49840 Q9WV60 Kinase Cytosol + Binding 9501208 AXIN O15169 O88566 Adapter Cytosol BETACATENIN P35222 Q02248 TF Cytosol _ Binding 9501208 GSK3 P49840 Q9WV60 Kinase Cytosol APC Q9H1A4 P53995 Adapter Cytosol + Phosphorylation 9601641 GSK3 P49840 Q9WV60 Kinase Cytosol BETACATENIN P35222 Q02248 TF Cytosol _ Phosphorylation 9601641 AXIN O15169 O88566 Adapter Cytosol GSK3 P49840 Q9WV60 Kinase Cytosol + Binding 9601641 AXIN O15169 O88566 Adapter Cytosol BETACATENIN P35222 Q02248 TF Cytosol _ Binding 9601641 AXIN O15169 O88566 Adapter Cytosol APC Q9H1A4 P53995 Adapter Cytosol 0 Binding 9601641 GSK3 P49840 Q9WV60 Kinase Cytosol APC Q9H1A4 P53995 Adapter Cytosol + Phosphorylation 8638126 APC Q9H1A4 P53995 Adapter Cytosol BETACATENIN P35222 Q02248 TF Cytosol _ Binding 8638126 AXIN O15169 O88566 Adapter Cytosol MEKK1 Q13233 P53349 Kinase Cytosol + Binding 11408485 AXIN O15169 O88566 Adapter Cytosol MEKK1 Q13233 P53349 Kinase Cytosol + Binding 12878610 AXIN O15169 O88566 Adapter Cytosol MEKK4 Q9Y6R4 NA Kinase Cytosol + Binding 12878610 DISHEVELED O14640 P51141 Adapter Membrane AXIN O15169 O88566 Adapter Cytosol _ Binding 11027605 DISHEVELED O14640 P51141 Adapter Membrane AXIN O15169 O88566 Adapter Cytosol _ Binding 10862053 PLCBETA Q9NQ66 P51432 Phospholipase Cytosol PIP2 NA NA Messenger Cytosol _ Cleavage 11941371 GALPHAI P08754 Q9DC51 Gprotein Cytosol AC2 Q08462 Q91WF3 Cyclase Cytosol _ Binding 8327893 CREM Q03060 Q01147 TF Nucleus CREB P16220 Q01147 TF Nucleus _ Binding 1847666 GRB2 P62993 Q60631 Adapter Cytosol DYNAMIN Q05193 P09922 GTPase Vesicles + Binding 9452513 PIP2 NA NA Messenger Cytosol DYNAMIN Q05193 P09922 GTPase Vesicles + Binding 9452513 PIP2 NA NA Messenger Cytosol DYNAMIN Q05193 P09922 GTPase Vesicles + Binding 9325335 GRB2 P62993 Q60631 Adapter Cytosol DYNAMIN Q05193 P09922 GTPase Vesicles + Binding 8402898 GRB2 P62993 Q60631 Adapter Cytosol DYNAMIN Q05193 P09922 GTPase Vesicles + Binding 7505438 SRC P12931 P05480 Kinase Cytosol DYNAMIN Q05193 P09922 GTPase Vesicles + Binding 7505438 TUBULIN P05209 P05209 Cytoskeleton Cytosol DYNAMIN Q05193 P09922 GTPase Vesicles + Binding 7505438 PIP2 NA NA Messenger Cytosol DYNAMIN Q05193 P09922 GTPase Vesicles + Binding 8947047 JIP Q9UQF2 Q9WVI9 Adapter Cytosol RASGRF Q13972 P27671 GEF Cytosol + Binding 12024021 JIP Q9UQF2 Q9WVI9 Adapter Cytosol TIAM1 Q13009 Q60610 GEF Cytosol + Binding 12024021 P38 Q16539 P47811 Kinase Cytosol ATF2 P15336 Q60765 TF Nucleus + Phosphorylation 12024021 JIP Q9UQF2 Q9WVI9 Adapter Cytosol P38 Q16539 P47811 Kinase Cytosol + Binding 12024021 INTEGRIN P05556 P09055 CellAdhesion Membrane RACK P25388 P25388 Adapter Cytosol 0 Binding 9442085 ALPHA7NACHR P36544 P49582 Receptor Membrane SODIUM NA NA Ion Cytosol + Opening 977572 ALPHA7NACHR P36544 P49582 Receptor Membrane SODIUM NA NA Ion Cytosol + Opening 3753746 ACH NA NA Ligand Extracellular ALPHA7NACHR P36544 P49582 Receptor Membrane + Binding 977572 ACH NA NA Ligand Extracellular ALPHA7NACHR P36544 P49582 Receptor Membrane + Binding 3753746 ARFGEF Q9Y6D5 P97694 GEF Vesicles ARF P32889 P32889 GTPase Vesicles + GEF 8945478 ARFGEF Q9Y6D5 P97694 GEF Vesicles ARF P32889 P32889 GTPase Vesicles + GEF 8945477 PKA P17612 P05132 Kinase Cytosol CBP Q92793 P45481 TF Nucleus + Phosphorylation 15299023 STAT1 P42224 P42225 TF Nucleus CBP Q92793 P45481 TF Nucleus 0 Binding 9037008 STAT1 P42224 P42225 TF Nucleus CBP Q92793 P45481 TF Nucleus 0 Binding 9773981 STAT5 P42229 P42230 TF Nucleus CBP Q92793 P45481 TF Nucleus 0 Binding 9037008 STAT5 P42229 P42230 TF Nucleus CBP Q92793 P45481 TF Nucleus 0 Binding 9773981 NFKB P19838 P25799 TF Nucleus CBP Q92793 P45481 TF Nucleus + Binding 9660950 PKG Q13237 Q9Z0Z0 Kinase Cytosol CREB P16220 Q01147 TF Nucleus + Phosphorylation 10575022 CREB P16220 Q01147 TF Nucleus CBP Q92793 P45481 TF Nucleus + Binding 8004670 CREB P16220 Q01147 TF Nucleus CBP Q92793 P45481 TF Nucleus + Binding 7870178 CREB P16220 Q01147 TF Nucleus CBP Q92793 P45481 TF Nucleus + Binding 7870179 CBP Q92793 P45481 TF Nucleus PCAF Q92831 Q9JHD2 TF Nucleus + Binding 8945521 CREB P16220 Q01147 TF Nucleus TFIID P21675 Q8C092 TF Nucleus + Binding 7906413 CREB P16220 Q01147 TF Nucleus TFIID P21675 Q8C092 TF Nucleus + Binding 7615553 PKA P17612 P05132 Kinase Cytosol DARPP32 Q9UD71 Q60829 Inhibitor Cytosol + Phosphorylation 3339428 PKA P17612 P05132 Kinase Cytosol DARPP32 Q9UD71 Q60829 Inhibitor Cytosol + Phosphorylation 6296685 PKA P17612 P05132 Kinase Cytosol DARPP32 Q9UD71 Q60829 Inhibitor Cytosol + Phosphorylation 6319628 P53 Q12888 P70399 TF Nucleus CBP Q92793 P45481 TF Nucleus 0 Binding 9215639 CBP Q92793 P45481 TF Nucleus TCF P36402 Q00417 TF Nucleus _ Binding 9774110 CBP Q92793 P45481 TF Nucleus BETACATENIN P35222 Q02248 TF Cytosol + Binding 10769018 CARM1 Q86X55 NA TF Nucleus BETACATENIN P35222 Q02248 TF Cytosol + Binding 11983685 FIBRONECTIN P02751 Q80Z71 Matrix Extracellular INTEGRIN P05556 P09055 CellAdhesion Membrane + Binding 6284125 DARPP32 Q9UD71 Q60829 Inhibitor Cytosol PP1 P36873 P37139 Phosphatase Cytosol _ Binding 9108011 DARPP32 Q9UD71 Q60829 Inhibitor Cytosol PP1 P36873 P37139 Phosphatase Cytosol _ Binding 6087160 SPAL Q96FS4 Q61037 GAP Cytosol RAP1 P10113 P10113 GTPase Cytosol _ GAP 12059963 PKA P17612 P05132 Kinase Cytosol BETA2AR P07550 P18762 Receptor Membrane _ Phosphorylation 2987243 ARFGAP Q8N6T3 Q9EPJ9 GAP Vesicles ARF P32889 P32889 GTPase Vesicles _ GAP 1010276 RAP1GAP P47736 Q61037 GAP Cytosol RAP1 P10113 P10113 GTPase Cytosol _ GAP 15141215 P1433 Q04917 P11576 Adapter Cytosol bRAF P15056 Q99N57 Kinase Cytosol + Binding 10931830 RGS4 P49798 O08899 GAP Cytosol GALPHAQ P50148 P21279 Gprotein Cytosol _ GAP 9012799 GAIP P49795 O70521 GAP Cytosol GALPHAQ P50148 P21279 Gprotein Cytosol _ GAP 9012799 MYOSINPPASE O60237 Q8BG95 Phosphatase Cytosol MYOSIN Q92614 Q9JMH9 Cytoskeleton Cytosol _ Dephosphorylation 186030 MKP1 P28562 P28563 Phosphatase Cytosol P38 Q16539 P47811 Kinase Cytosol _ Dephosphorylation 8626452 MKP1 P28562 P28563 Phosphatase Cytosol MAPK P28482 P27703 Kinase Cytosol _ Dephosphorylation 8626452 MKP1 P28562 P28563 Phosphatase Cytosol MAPK P28482 P27703 Kinase Cytosol _ Dephosphorylation 8221888 MKP1 P28562 P28563 Phosphatase Cytosol JNK P45983 Q91Y86 Kinase Nucleus _ Dephosphorylation 8626452 DISHEVELED O14640 P51141 Adapter Membrane AXIN O15169 O88566 Adapter Cytosol _ Binding 10330181 FAK Q05397 Q60750 Kinase Cytosol SHC P29353 Q61120 Adapter Cytosol + Phosphorylation 10725339 PTEN P60483 O08586 Phosphatase Cytosol FAK Q05397 Q60750 Kinase Cytosol _ Dephosphorylation 9616126 PAR2 P55085 P30558 Receptor Membrane GBETAGAMMA P11016 P11016 Gprotein Cytosol + Binding 7937743 PAR2 P55085 P30558 Receptor Membrane GBETAGAMMA P11016 P11016 Gprotein Cytosol + Binding 8615752 PAR2 P55085 P30558 Receptor Membrane GBETAGAMMA P11016 P11016 Gprotein Cytosol + Binding 9349532 PAR2 P55085 P30558 Receptor Membrane GALPHAQ P50148 P21279 Gprotein Cytosol + Binding 9349532 TRYPSIN P07477 P07146 Protease Extracellular PAR2 P55085 P30558 Receptor Membrane + Binding 9349532 BETAARRESTIN P49407 Q91YI4 Adapter Cytosol PAR2 P55085 P30558 Receptor Membrane _ Binding 10725339 AP2 P53680 P61966 Adapter Vesicles CLATHRIN P09496 O08585 Vesicle Vesicles 0 Binding 2912448 AP2 P53680 P61966 Adapter Vesicles CLATHRIN P09496 O08585 Vesicle Vesicles 0 Binding 1902233 AP2 P53680 P61966 Adapter Vesicles CLATHRIN P09496 O08585 Vesicle Vesicles 0 Binding 7559550 AMPAR P42261 P23818 Channel Membrane AP2 P53680 P61966 Adapter Vesicles 0 Binding 12441055 PYK2 Q14289 Q60629 Kinase Cytosol EGFR P00533 Q01279 Receptor Membrane + Phosphorylation 11274221 PYK2 Q14289 Q60629 Kinase Cytosol SRC P12931 P05480 Kinase Cytosol + Binding 11274221 ACTIN P60712 P60711 Cytoskeleton Cytosol FASCIN O94856 Q810U3 CellAdhesion Membrane 0 Binding 8999969 PKC P17252 P05697 Kinase Cytosol FASCIN O94856 Q810U3 CellAdhesion Membrane _ Phosphorylation 8999969 SHC P29353 Q61120 Adapter Cytosol SOS Q07889 Q02384 GEF Cytosol + Binding 8114695 ABL P00519 P00520 Kinase Cytosol CDK5 Q00535 P49615 Kinase Cytosol + Phosphorylation 11113134 TRKA P04629 Q9Z139 Receptor Membrane GRB2 P62993 Q60631 Adapter Cytosol + Binding 10748052 MEK2 Q9Y2U5 Q61083 Kinase Cytosol PRK2 Q9HC23 Q9QXU7 Kinase Cytosol + Binding 10818102 RHO Q07960 Q8C0D4 GTPase Cytosol PKC P17252 P05697 Kinase Cytosol 0 Binding 11284700 GBETAGAMMA P11016 P11016 Gprotein Cytosol AC1 Q08828 Q01341 Cyclase Cytosol _ Binding 2022671 CALCIUM NA NA Messenger Cytosol AC5 O95622 Q01341 Cyclase Membrane _ Binding 12065575 GALPHAI P08754 Q9DC51 Gprotein Cytosol AC5 O95622 Q01341 Cyclase Membrane _ Binding 8327893 TUBERIN P49815 Q61037 GAP Cytosol RAP1 P10113 P10113 GTPase Cytosol _ GAP 7608212 SYNAPSIN P17600 O88935 Vesicle Vesicles GALPHAZ P19086 O70443 Gprotein Cytosol _ Binding 14557263 PKA P17612 P05132 Kinase Cytosol SYNAPSIN P17600 O88935 Vesicle Vesicles _ Phosphorylation 14557263 PAK Q13153 O88643 Kinase Cytosol SYNAPSIN P17600 O88935 Vesicle Vesicles _ Phosphorylation 14557263 D2R P14416 P61168 Receptor Membrane GALPHAZ P19086 O70443 Gprotein Cytosol + Binding 10384262 D2R P14416 P61168 Receptor Membrane GALPHAI P08754 Q9DC51 Gprotein Cytosol + Binding 10384262 FIVEHT1AR P08908 Q64264 Receptor Membrane GALPHAZ P19086 O70443 Gprotein Cytosol + Binding 9407078 GALPHAZ P19086 O70443 Gprotein Cytosol AC5 O95622 Q01341 Cyclase Membrane _ Binding 7829508 GALPHAZ P19086 O70443 Gprotein Cytosol AC1 Q08828 Q01341 Cyclase Cytosol _ Binding 7829508 IKBA P25963 Q9Z1E3 Inhibitor Cytosol NFKB P19838 P25799 TF Nucleus _ Binding 2184941 CBL Q13191 P22682 Ubiquitinase Cytosol VAV P52735 Q60992 GEF Cytosol _ Ubiquitination 12881521 CREM Q03060 Q01147 TF Nucleus DREAM Q9Y2W7 Q9QXT8 TF Nucleus _ Binding 12198160 CALCINEURIN P06705 P61023 Phosphatase Cytosol DARPP32 Q9UD71 Q60829 Inhibitor Cytosol _ Dephosphorylation 6330098 PKA P17612 P05132 Kinase Cytosol D1R P21728 Q61616 Receptor Membrane _ Phosphorylation 7609904 SIAH O43255 Q06986 Adapter Cytosol VAV P52735 Q60992 GEF Cytosol _ Binding 10207103 NMDAR Q12879 P35436 Receptor Membrane ALPHAACTININ Q08043 O88990 Cytoskeletal Cytosol 0 Binding 9009191 NMDAR Q12879 P35436 Receptor Membrane ALPHAACTININ Q08043 O88990 Cytoskeletal Cytosol 0 Binding 11246149 PSD95 P78352 Q62108 Adapter Cytosol ALPHAACTININ Q08043 O88990 Cytoskeletal Cytosol 0 Binding 9009191 DOK Q99704 O70469 Adapter Cytosol RASGAP Q8IV61 Q91ZC8 GAP Cytosol + Binding 9233798 DOK Q99704 O70469 Adapter Cytosol RASGAP Q8IV61 Q91ZC8 GAP Cytosol + Binding 9008161 ABL P00519 P00520 Kinase Cytosol DOK Q99704 O70469 Adapter Cytosol + Binding 9008161 ABL P00519 P00520 Kinase Cytosol DOK Q99704 O70469 Adapter Cytosol + Binding 12777393 EPHB2 P52799 P52800 Receptor Membrane DOK Q99704 O70469 Adapter Cytosol + Phosphorylation 9233798 EPHB2 P52799 P52800 Receptor Membrane RASGAP Q8IV61 Q91ZC8 GAP Cytosol + Phosphorylation 9233798 DOK Q99704 O70469 Adapter Cytosol NCK P16333 Q60631 Adapter Cytosol 0 Binding 10202139 EPHRIN NA NA Ligand Extracellular EPHB2 P52799 P52800 Receptor Membrane + Binding 9233798 DOK Q99704 O70469 Adapter Cytosol NCK P16333 Q60631 Adapter Cytosol 0 Binding 9233798 BETAARRESTIN P49407 Q91YI4 Adapter Cytosol BETA2AR P07550 P18762 Receptor Membrane _ Binding 11171997 AMPAR P42261 P23818 Channel Membrane STARGAZIN Q9BXT1 Q9BXT1 Chaperone Cytosol 0 Binding 12359873 WNT Q9Y6F9 P22724 Ligand Extracellular FRIZZLED Q9UP38 O70421 Receptor Membrane + Binding 8717036 WNT Q9Y6F9 P22724 Ligand Extracellular FRIZZLED Q9UP38 O70421 Receptor Membrane + Binding 12857724 WNT Q9Y6F9 P22724 Ligand Extracellular LRP Q9BQ69 P00755 Receptor Membrane + Binding 12857724 GABAAR P14867 P18504 Receptor Membrane CHLORIDE NA NA Ion Cytosol + Opening 2848320 NE NA NA Ligand Extracellular ALPHA1AR P35348 P97718 Receptor Membrane + Binding 9733758 NE NA NA Ligand Extracellular ALPHA2AR P08913 Q01338 Receptor Membrane + Binding 9733758 NE NA NA Ligand Extracellular BETA2AR P07550 P18762 Receptor Membrane + Binding 15102960 NE NA NA Ligand Extracellular ALPHA1AR P35348 P97718 Receptor Membrane + Binding 3016604 NE NA NA Ligand Extracellular ALPHA2AR P08913 Q01338 Receptor Membrane + Binding 3016604 NE NA NA Ligand Extracellular BETA2AR P07550 P18762 Receptor Membrane + Binding 3016604 NE NA NA Ligand Extracellular BETA2AR P07550 P18762 Receptor Membrane + Binding 6324206 CBL Q13191 P22682 Ubiquitinase Cytosol SRC P12931 P05480 Kinase Cytosol _ Ubiquitination 11448952 CBL Q13191 P22682 Ubiquitinase Cytosol PI3K P42336 P42337 Kinase Cytosol _ Ubiquitination 11087752 CBL Q13191 P22682 Ubiquitinase Cytosol SHC P29353 Q61120 Adapter Cytosol _ Ubiquitination 11375397 CBL Q13191 P22682 Ubiquitinase Cytosol EGFR P00533 Q01279 Receptor Membrane _ Ubiquitination 11375397 CBL Q13191 P22682 Ubiquitinase Cytosol GRB2 P62993 Q60631 Adapter Cytosol _ Ubiquitination 11375397 IRS1 P35568 P35569 Adapter Cytosol GRB2 P62993 Q60631 Adapter Cytosol + Binding 8265614 KV41 Q9NSA2 Q03719 Channel Membrane Potassium NA NA Ion Cytosol + Opening 11723117 KV41 Q9NSA2 Q03719 Channel Membrane Potassium NA NA Ion Cytosol + Opening 9437018 KV41 Q9NSA2 Q03719 Channel Membrane PSD95 P78352 Q62108 Adapter Cytosol 0 Binding 11723117 CAMKII Q9UQM7 P11798 Kinase Cytosol KV42 Q9NZV8 Q9Z0V2 Channel Membrane + Phosphorylation 15071113 DREAM Q9Y2W7 Q9QXT8 TF Nucleus KV42 Q9NZV8 Q9Z0V2 Channel Membrane _ Binding 12829703 DREAM Q9Y2W7 Q9QXT8 TF Nucleus KV42 Q9NZV8 Q9Z0V2 Channel Membrane _ Binding 12451113 PKA P17612 P05132 Kinase Cytosol KV42 Q9NZV8 Q9Z0V2 Channel Membrane _ Phosphorylation 12451113 DREAM Q9Y2W7 Q9QXT8 TF Nucleus KV41 Q9NSA2 Q03719 Channel Membrane _ Binding 12829703 KV14 P22459 Q61423 Channel Membrane Potassium NA NA Ion Cytosol + Opening 9437018 SNAP25 P60878 P60881 Vesicle Vesicles NTYPECA Q00975 P97445 Channel Membrane _ Binding 8559250 SYNTAXIN Q13277 O35526 Vesicle Vesicles NTYPECA Q00975 P97445 Channel Membrane _ Binding 8559250 PKA P17612 P05132 Kinase Cytosol TAU P10636 P20357 Activator Cytosol + Phosphorylation 6412713 CASK Q9HCP0 Q8BTH8 Kinase Cytosol TAU P10636 P20357 Activator Cytosol + Phosphorylation 6412713 PKA P17612 P05132 Kinase Cytosol TAU P10636 P20357 Activator Cytosol + Phosphorylation 1730702 CALPAIN P07384 O35350 Protease Cytosol TAU P10636 P20357 Activator Cytosol _ Cleavage 1730702 MAPK P28482 P27703 Kinase Cytosol TAU P10636 P20357 Activator Cytosol + Phosphorylation 7488031 MAPK P28482 P27703 Kinase Cytosol TAU P10636 P20357 Activator Cytosol + Phosphorylation 8166686 GRB2 P62993 Q60631 Adapter Cytosol GAB1 Q13480 Q9QYY0 Adapter Cytosol + Binding 8596638 GAB1 Q13480 Q9QYY0 Adapter Cytosol PI3K P42336 P42337 Kinase Cytosol + Binding 8596638 M4R P08173 P32211 Receptor Membrane EEF1A2 Q05639 P62631 Elongation Ribosomes + Binding 12048193 ACH NA NA Ligand Extracellular M4R P08173 P32211 Receptor Membrane + Binding 7916637 M4R P08173 P32211 Receptor Membrane GALPHAI P08754 Q9DC51 Gprotein Cytosol + Binding 7916637 M4R P08173 P32211 Receptor Membrane GBETAGAMMA P11016 P11016 Gprotein Cytosol + Binding 7916637 CALMODULIN P62158 P62204 Activator Cytosol PLCBETA Q9NQ66 P51432 Phospholipase Cytosol + Binding 12821674 M4R P08173 P32211 Receptor Membrane GALPHAI P08754 Q9DC51 Gprotein Cytosol + Binding 10347206 GLUTAMATE NA NA Ligand Extracellular KAR P39086 Q60934 Channel Membrane + Binding 1373382 KAR P39086 Q60934 Channel Membrane PSD95 P78352 Q62108 Adapter Cytosol 0 Binding 12597860 KAR P39086 Q60934 Channel Membrane SYNTENIN O00560 Q99JZ0 Adapter Cytosol 0 Binding 12597860 KAR P39086 Q60934 Channel Membrane SYNTENIN O00560 Q99JZ0 Adapter Cytosol 0 Binding 11891216 KAR P39086 Q60934 Channel Membrane PICK1 Q9NRD5 Q62083 Adapter Cytosol 0 Binding 12597860 KAR P39086 Q60934 Channel Membrane PICK1 Q9NRD5 Q62083 Adapter Cytosol 0 Binding 11891216 PKA P17612 P05132 Kinase Cytosol KAR P39086 Q60934 Channel Membrane + Phosphorylation 8094892 PKC P17252 P05697 Kinase Cytosol KAR P39086 Q60934 Channel Membrane + Phosphorylation 12597860 KAR P39086 Q60934 Channel Membrane GRIP Q96CN9 Q9QYE6 Adapter Cytosol 0 Binding 12597860 KAR P39086 Q60934 Channel Membrane GRIP Q96CN9 Q9QYE6 Adapter Cytosol 0 Binding 11891216 CALCINEURIN P06705 P61023 Phosphatase Cytosol GABAAR P14867 P18504 Receptor Membrane + Dephosphorylation 8888004 PKA P17612 P05132 Kinase Cytosol AMPAR P42261 P23818 Channel Membrane + Phosphorylation 12843287 GBETAGAMMA P11016 P11016 Gprotein Cytosol PQCaCh O00555 P97445 Channel Membrane + Binding 9009193 AMPAR P42261 P23818 Channel Membrane GRIP Q96CN9 Q9QYE6 Adapter Cytosol 0 Binding 9069286 PKC P17252 P05697 Kinase Cytosol NTYPECA Q00975 P97445 Channel Membrane + Phosphorylation 8380626 PKC P17252 P05697 Kinase Cytosol NTYPECA Q00975 P97445 Channel Membrane + Phosphorylation 9278528 CAMKII Q9UQM7 P11798 Kinase Cytosol NTYPECA Q00975 P97445 Channel Membrane + Phosphorylation 9278528 SYNTAXIN Q13277 O35526 Vesicle Vesicles NTYPECA Q00975 P97445 Channel Membrane _ Binding 9278528 SNAP25 P60878 P60881 Vesicle Vesicles NTYPECA Q00975 P97445 Channel Membrane _ Binding 9278528 SNAP25 P60878 P60881 Vesicle Vesicles NTYPECA Q00975 P97445 Channel Membrane _ Binding 11312277 PICK1 Q9NRD5 Q62083 Adapter Cytosol AMPAR P42261 P23818 Channel Membrane 0 Binding 10340301 PKC P17252 P05697 Kinase Cytosol PICK1 Q9NRD5 Q62083 Adapter Cytosol 0 Phosphorylation 10340301 PKC P17252 P05697 Kinase Cytosol AMPAR P42261 P23818 Channel Membrane _ Phosphorylation 12805550 CALMODULIN P62158 P62204 Activator Cytosol IP3R Q14643 P11881 Channel ER _ Binding 7755592 GLUTAMATE NA NA Ligand Extracellular AMPAR P42261 P23818 Channel Membrane + Binding 8589990 AMPAR P42261 P23818 Channel Membrane SODIUM NA NA Ion Cytosol + Opening 8589990 CAMKII Q9UQM7 P11798 Kinase Cytosol RYR P21817 Q80X16 Channel ER + Phosphorylation 1645727 CALCIUM NA NA Messenger Cytosol ALPHAACTININ Q08043 O88990 Cytoskeletal Cytosol _ Binding 9952395 CALMODULIN P62158 P62204 Activator Cytosol NMDAR Q12879 P35436 Receptor Membrane _ Binding 9952395 NMDAR Q12879 P35436 Receptor Membrane ALPHAACTININ Q08043 O88990 Cytoskeletal Cytosol 0 Binding 9952395 CALMODULIN P62158 P62204 Activator Cytosol NMDAR Q12879 P35436 Receptor Membrane _ Binding 8625412 SYNTAXIN Q13277 O35526 Vesicle Vesicles GAT1 P43003 P56564 Transporter Membrane 0 Binding 9698305 SYNTAPHILIN O15079 P42567 Vesicle Vesicles SYNTAXIN Q13277 O35526 Vesicle Vesicles _ Binding 10707983 GAT1 P43003 P56564 Transporter Membrane GABA NA NA Ligand Extracellular _ Importing 7472524 GAT1 P43003 P56564 Transporter Membrane GABA NA NA Ligand Extracellular _ Importing 1975955 SAP97 Q12959 P70175 Adapter Cytosol AMPAR P42261 P23818 Channel Membrane 0 Binding 12070168 SAP97 Q12959 P70175 Adapter Cytosol KAR P39086 Q60934 Channel Membrane _ Binding 9808460 HOMER Q9NSB8 Q99JP6 Adapter Cytosol RYR P21817 Q80X16 Channel ER + Binding 12223488 MLK3 Q02779 Q60700 Kinase Cytosol MEK4 P45985 P47809 Kinase Cytosol + Phosphorylation 8702571 PAK Q13153 O88643 Kinase Cytosol LIMK P53667 P53668 Kinase Cytosol + Phosphorylation 10559936 ROCK O75116 P70336 Kinase Cytosol LIMK P53667 P53668 Kinase Cytosol + Phosphorylation 10652353 CALMODULIN P62158 P62204 Activator Cytosol DAPK P53355 Q8VDF3 Kinase Cytosol + Binding 9367156 SMACDIABLO Q9NR28 Q99M73 Inhibitor Mitochondria XIAP P98170 Q60989 Inhibitor Cytosol _ Binding 10929712 XIAP P98170 Q60989 Inhibitor Cytosol CASPASE3 P42574 P70677 Protease Cytosol _ Binding 9230442 XIAP P98170 Q60989 Inhibitor Cytosol CASPASE7 P55210 P97864 Protease Cytosol _ Binding 9230442 XIAP P98170 Q60989 Inhibitor Cytosol CASPASE9 P55211 Q9R0T0 Protease Cytosol _ Binding 12620238 XIAP P98170 Q60989 Inhibitor Cytosol CASPASE3 P42574 P70677 Protease Cytosol _ Binding 10508158 XIAP P98170 Q60989 Inhibitor Cytosol CASPASE7 P55210 P97864 Protease Cytosol _ Binding 10508158 XIAP P98170 Q60989 Inhibitor Cytosol CASPASE9 P55211 Q9R0T0 Protease Cytosol _ Binding 10508158 cIAP1 Q13490 O08863 Inhibitor Cytosol CASPASE3 P42574 P70677 Protease Cytosol _ Binding 9384571 cIAP1 Q13490 O08863 Inhibitor Cytosol CASPASE7 P55210 P97864 Protease Cytosol _ Binding 9384571 cIAP2 Q13489 O08863 Inhibitor Cytosol CASPASE3 P42574 P70677 Protease Cytosol _ Binding 9384571 cIAP2 Q13489 O08863 Inhibitor Cytosol CASPASE7 P55210 P97864 Protease Cytosol _ Binding 9384571 XIAP O15392 O70201 Inhibitor Cytosol CASPASE3 P42574 P70677 Protease Cytosol _ Binding 9384571 XIAP O15392 O70201 Inhibitor Cytosol CASPASE7 P55210 P97864 Protease Cytosol _ Binding 9384571 CYTOCHROMEC P10606 P19536 DualRole Mitochondria APAF1 O14727 O88879 Adapter Cytosol + Binding 9267021 CYTOCHROMEC P10606 P19536 DualRole Mitochondria APAF1 O14727 O88879 Adapter Cytosol + Binding 9390557 APAF1 O14727 O88879 Adapter Cytosol CASPASE9 P55211 Q9R0T0 Protease Cytosol + Cleavage 9651578 APAF1 O14727 O88879 Adapter Cytosol CASPASE9 P55211 Q9R0T0 Protease Cytosol + Cleavage 9390557 APAF1 O14727 O88879 Adapter Cytosol CASPASE9 P55211 Q9R0T0 Protease Cytosol + Cleavage 9837928 dATP NA NA Messenger Cytosol APAF1 O14727 O88879 Adapter Cytosol + Binding 10364241 dATP NA NA Messenger Cytosol APAF1 O14727 O88879 Adapter Cytosol + Binding 9390557 NAIP Q13075 Q9QWK5 Inhibitor Cytosol CASPASE9 P55211 Q9R0T0 Protease Cytosol _ Binding 15280366 CALCIUM NA NA Messenger Cytosol HIPPOCALCIN P84074 P84075 Adapter Cytosol + Binding 8166736 CALCIUM NA NA Messenger Cytosol HIPPOCALCIN P84074 P84075 Adapter Cytosol + Binding 1280427 HIPPOCALCIN P84074 P84075 Adapter Cytosol NAIP Q13075 Q9QWK5 Inhibitor Cytosol + Binding 15280366 HIPPOCALCIN P84074 P84075 Adapter Cytosol NAIP Q13075 Q9QWK5 Inhibitor Cytosol + Binding 10899114 NAIP Q13075 Q9QWK5 Inhibitor Cytosol CASPASE3 P42574 P70677 Protease Cytosol _ Binding 11896143 NAIP Q13075 Q9QWK5 Inhibitor Cytosol CASPASE7 P55210 P97864 Protease Cytosol _ Binding 11896143 APOLLON Q9NR09 NA Ubiquitinase Cytosol SMACDIABLO Q9NR28 Q99M73 Inhibitor Mitochondria _ Ubiquitination 15300255 APOLLON Q9NR09 NA Ubiquitinase Cytosol CASPASE9 P55211 Q9R0T0 Protease Cytosol _ Ubiquitination 15300255 SURVIVIN O15392 O70201 Adapter Cytosol SMACDIABLO Q9NR28 Q99M73 Inhibitor Mitochondria _ Binding 12660240 PKA P17612 P05132 Kinase Cytosol MAP2 P11137 P20357 Cytoskeleton Cytosol + Phosphorylation 2561875 PKA P17612 P05132 Kinase Cytosol MAP2 P11137 P20357 Cytoskeleton Cytosol + Phosphorylation 12369833 PKC P17252 P05697 Kinase Cytosol MAP2 P11137 P20357 Cytoskeleton Cytosol + Phosphorylation 2561875 CAMKII Q9UQM7 P11798 Kinase Cytosol MAP2 P11137 P20357 Cytoskeleton Cytosol + Phosphorylation 2561875 PKC P17252 P05697 Kinase Cytosol MBP P02686 P04370 Cytoskeleton Cytosol + Phosphorylation 10460230 TUBULIN P05209 P05209 Cytoskeleton Cytosol GRB2 P62993 Q60631 Adapter Cytosol 0 Binding 8910394 TUBULIN P05209 P05209 Cytoskeleton Cytosol PI3K P42336 P42337 Kinase Cytosol 0 Binding 8910394 DYNEIN Q15701 Q15701 Adapter Cytosol TUBULIN P05209 P05209 Cytoskeleton Cytosol 0 Binding 10679011 MAP1B P46821 P14873 Activator Cytosol TUBULIN P05209 P05209 Cytoskeleton Cytosol 0 Binding 10679011 SYK P43405 Q01279 Kinase Cytosol TUBULIN P05209 P05209 Cytoskeleton Cytosol + Phosphorylation 8617742 ZAP70 P43403 P05480 Kinase Cytosol TUBULIN P05209 P05209 Cytoskeleton Cytosol + Phosphorylation 8617742 FYN P06241 P39688 Kinase Cytosol TUBULIN P05209 P05209 Cytoskeleton Cytosol + Phosphorylation 7678277 LYN P07948 P08103 Kinase Cytosol TUBULIN P05209 P05209 Cytoskeleton Cytosol + Phosphorylation 7678277 SRC P12931 P05480 Kinase Cytosol CORTACTIN Q14247 Q60598 Cytoskeleton Cytosol _ Phosphorylation 7680654 CORTACTIN Q14247 Q60598 Cytoskeleton Cytosol DYNAMIN Q05193 P09922 GTPase Vesicles 0 Binding 7680654 ACTIN P60712 P60711 Cytoskeleton Cytosol CORTACTIN Q14247 Q60598 Cytoskeleton Cytosol 0 Binding 7680654 CALMODULIN P62158 P62204 Activator Cytosol MARCKS P29966 P26645 Adapter Cytosol _ Binding 1560845 CALMODULIN P62158 P62204 Activator Cytosol MARCKS P29966 P26645 Adapter Cytosol _ Binding 2557349 ACTIN P60712 P60711 Cytoskeleton Cytosol MARCKS P29966 P26645 Adapter Cytosol 0 Binding 1560845 PKC P17252 P05697 Kinase Cytosol MARCKS P29966 P26645 Adapter Cytosol _ Phosphorylation 1560845 CDK5 Q00535 P49615 Kinase Cytosol NFH P12036 P08553 Cytoskeleton Cytosol + Phosphorylation 7760048 PP2A Q13362 Q80W65 Phosphatase Cytosol NFH P12036 P08553 Cytoskeleton Cytosol _ Dephosphorylation 7760048 NMDAR Q12879 P35436 Receptor Membrane TUBULIN P05209 P05209 Cytoskeleton Cytosol 0 Binding 10037467 PP1 P36873 P37139 Phosphatase Cytosol COFILIN P23528 P18760 Cytoskeleton Cytosol + Dephosphorylation 11093160 PP2A Q13362 Q80W65 Phosphatase Cytosol COFILIN P23528 P18760 Cytoskeleton Cytosol + Dephosphorylation 11093160 COFILIN P23528 P18760 Cytoskeleton Cytosol ACTIN P60712 P60711 Cytoskeleton Cytosol _ Binding 10980704 COFILIN P23528 P18760 Cytoskeleton Cytosol ACTIN P60712 P60711 Cytoskeleton Cytosol _ Binding 15364581 GELSOLIN P06396 P13020 Cytoskeleton Cytosol ACTIN P60712 P60711 Cytoskeleton Cytosol _ Cleavage 9334393 PROFILIN P47756 P47757 Cytoskeleton Cytosol PIP2 NA NA Lipid Cytosol + Binding 2157283 PROFILIN P47756 P47757 Cytoskeleton Cytosol PIP2 NA NA Lipid Cytosol + Binding 9034331 PROFILIN P47756 P47757 Cytoskeleton Cytosol PIP2 NA NA Lipid Cytosol + Binding 12052260 CASPASE6 P55212 O08738 Protease Cytosol LAMINA P02545 P14733 Cytoskeleton Nucleus _ Cleavage 11953316 CASPASE3 P42574 P70677 Protease Cytosol GELSOLIN P06396 P13020 Cytoskeleton Cytosol _ Cleavage 9323209 PIP2 NA NA Lipid Cytosol GELSOLIN P06396 P13020 Cytoskeleton Cytosol + Binding 10660524 GELSOLIN P06396 P13020 Cytoskeleton Cytosol CASPASE9 P55211 Q9R0T0 Protease Cytosol _ Binding 10660524 CALCINEURIN P06705 P61023 Phosphatase Cytosol MAP2 P11137 P20357 Cytoskeleton Cytosol _ Dephosphorylation 8393539 CALCINEURIN P06705 P61023 Phosphatase Cytosol MAP2 P11137 P20357 Cytoskeleton Cytosol _ Dephosphorylation 2987415 CALCINEURIN P06705 P61023 Phosphatase Cytosol TAU P10636 P20357 Activator Cytosol _ Dephosphorylation 2987415 CALCINEURIN P06705 P61023 Phosphatase Cytosol TUBULIN P05209 P05209 Cytoskeleton Cytosol _ Dephosphorylation 2987415 MAPK P28482 P27703 Kinase Cytosol NFH P12036 P08553 Cytoskeleton Cytosol _ Phosphorylation 9592082 MAPK P28482 P27703 Kinase Cytosol NFM P07197 P08553 Cytoskeleton Cytosol _ Phosphorylation 9592082 CALPAIN P07384 O35350 Protease Cytosol SPECTRIN O15020 Q62261 Cytoskeleton Cytosol _ Cleavage 11880203 PKC P17252 P05697 Kinase Cytosol ADDUCIN P35611 Q9QYB5 Adapter Cytosol _ Phosphorylation 9679146 CALMODULIN P62158 P62204 Activator Cytosol ADDUCIN P35611 Q9QYB5 Adapter Cytosol + Binding 9679146 PKC P17252 P05697 Kinase Cytosol ADDUCIN P35611 Q9QYB5 Adapter Cytosol _ Phosphorylation 8810272 CALMODULIN P62158 P62204 Activator ADDUCIN P35611 Q9QYB5 Adapter Cytosol + Binding 8810272 PKA P17612 P05132 Kinase Cytosol ADDUCIN P35611 Q9QYB5 Adapter Cytosol _ Phosphorylation 8810272 CALMODULIN P62158 P62204 Activator Cytosol SPECTRIN O15020 Q62261 Cytoskeleton Cytosol _ Binding 2492524 TUBULIN P05209 P05209 Cytoskeleton Cytosol GABARAP Q9BY60 P60518 Adapter Cytosol 0 Binding 11779480 ACTIN P60712 P60711 Cytoskeleton Cytosol N41 P11171 P48193 Adapter Cytosol 0 Binding 12399578 EGFR P00533 Q01279 Receptor Membrane N41 P11171 P48193 Adapter Cytosol + Phosphorylation 1647028 ACTIN P60712 P60711 Cytoskeleton Cytosol SPECTRIN O15020 Q62261 Cytoskeleton Cytosol 0 Binding 1647028 N41 P11171 P48193 Adapter Cytosol SPECTRIN O15020 Q62261 Cytoskeleton Cytosol 0 Binding 1647028 ACTIN P60712 P60711 Cytoskeleton Cytosol IQGAP P46940 Q9JKF1 GAP Cytosol 0 Binding 11809768 ACTIN P60712 P60711 Cytoskeleton Cytosol IQGAP P46940 Q9JKF1 GAP Cytosol 0 Binding 9199170 CORTACTIN Q14247 Q60598 Cytoskeleton Cytosol SHANK Q9Y566 P31695 Adapter Cytosol 0 Binding 10433268 SYNAPSIN P17600 O88935 Vesicle Vesicles ACTIN P60712 P60711 Cytoskeleton Cytosol + Binding 7849051 CAMKII Q9UQM7 P11798 Kinase Cytosol SYNAPSIN P17600 O88935 Vesicle Vesicles _ Phosphorylation 7849051 PKA P17612 P05132 Kinase Cytosol SYNAPSIN P17600 O88935 Vesicle Vesicles _ Phosphorylation 7849051 ACTIN P60712 P60711 Cytoskeleton Cytosol ALPHAACTININ Q08043 O88990 Cytoskeletal Cytosol 0 Binding 1107334 ANKYRIN P16157 Q02357 Cytoskeleton Cytosol SPECTRIN O15020 Q62261 Cytoskeleton Cytosol 0 Binding 2933395 CASK Q9HCP0 Q8BTH8 Kinase Cytosol ANKYRIN P16157 Q02357 Cytoskeleton Cytosol _ Phosphorylation 2933395 SPECTRIN O15020 Q62261 Cytoskeleton Cytosol ICA512 Q16849 P80560 Receptor Membrane 0 Binding 11086001 VASP P50552 P70460 Adapter Cytosol PROFILIN P47756 P47757 Cytoskeleton Cytosol 0 Binding 9034331 ROCK O75116 P70336 Kinase Cytosol PROFILIN P47756 P47757 Cytoskeleton Cytosol + Phosphorylation 14517206 PKA P17612 P05132 Kinase Cytosol FILAMIN P21333 Q8BTM8 Cytoskeleton Cytosol + Phosphorylation 15228085 ACTIN P60712 P60711 Cytoskeleton Cytosol FILAMIN P21333 Q8BTM8 Cytoskeleton Cytosol 0 Binding 325564 PKA P17612 P05132 Kinase Cytosol FILAMIN P21333 Q8BTM8 Cytoskeleton Cytosol + Phosphorylation 207708 KINESIN Q07866 Q9DBS5 Cytoskeleton Cytosol JIP Q9UQF2 Q9WVI9 Adapter Cytosol 0 Binding 11238452 ACTIN P60712 P60711 Cytoskeleton Cytosol NEURABIN Q9ULJ8 Q99NH2 Adapter Cytosol 0 Binding 9362513 TALIN Q9Y490 P26039 Cytoskeleton Cytosol INTEGRIN P05556 P09055 CellAdhesion Membrane 0 Binding 7716514 TALIN Q9Y490 P26039 Cytoskeleton Cytosol INTEGRIN P05556 P09055 CellAdhesion Membrane 0 Binding 3124107 ACTIN P60712 P60711 Cytoskeleton Cytosol VINCULIN P18206 Q64727 Cytoskeleton Cytosol 0 Binding 6789327 VINCULIN P18206 Q64727 Cytoskeleton Cytosol TALIN Q9Y490 P26039 Cytoskeleton Cytosol 0 Binding 6425696 PAXILLIN P49023 Q8CI51 Adapter Cytosol PAK Q13153 O88643 Kinase Cytosol 0 Binding 11096073 PAK Q13153 O88643 Kinase Cytosol COOL Q14155 Q9ES28 GEF Cytosol + Binding 11096073 PAK Q13153 O88643 Kinase Cytosol COOL Q14155 Q9ES28 GEF Cytosol + Binding 9726964 SHANK Q9Y566 P31695 Adapter Cytosol COOL Q14155 Q9ES28 GEF Cytosol + Binding 12626503 GIT1 Q9Y2X7 Q9JLQ2 Adapter Cytosol COOL Q14155 Q9ES28 GEF Cytosol 0 Binding 12695502 ACTIN P60712 P60711 Cytoskeleton Cytosol TALIN Q9Y490 P26039 Cytoskeleton Cytosol 0 Binding 2121138 PKCE Q02156 P16054 Kinase Cytosol ACTIN P60712 P60711 Cytoskeleton Cytosol 0 Binding 9756923 MAP2 P11137 P20357 Cytoskeleton Cytosol TUBULIN P05209 P05209 Cytoskeleton Cytosol 0 Binding 11278895 MAP1A P78559 Q9QYR6 Cytoskeleton Cytosol TUBULIN P05209 P05209 Cytoskeleton Cytosol 0 Binding 11278895 MAP1B P46821 P14873 Cytoskeleton Cytosol TUBULIN P05209 P05209 Cytoskeleton Cytosol 0 Binding 11278895 PSD95 P78352 Q62108 Adapter Cytosol CRIPT Q9P021 Q9Z1F9 Adapter Cytosol 0 Binding 9581762 PSD95 P78352 Q62108 Adapter Cytosol CRIPT Q9P021 Q9Z1F9 Adapter Cytosol 0 Binding 10570482 CRIPT Q9P021 Q9Z1F9 Adapter Cytosol TUBULIN P05209 P05209 Cytoskeleton Cytosol 0 Binding 10570482 CALPAIN P07384 O35350 Protease Cytosol MAP2 P11137 P20357 Cytoskeleton Cytosol _ Cleavage 8391085 PKA P17612 P05132 Kinase Cytosol MAP2 P11137 P20357 Cytoskeleton Cytosol + Phosphorylation 8391085 MYOSINV Q8NFW9 Q8K3I4 Cytoskeleton Cytosol CAMKII Q9UQM7 P11798 Kinase Cytosol + Binding 10336484 CALMODULIN P62158 P62204 Activator Cytosol MYOSINV Q8NFW9 Q8K3I4 Cytoskeleton Cytosol 0 Binding 10336484 CALMODULIN P62158 P62204 Activator Cytosol MYOSINV Q8NFW9 Q8K3I4 Cytoskeleton Cytosol 0 Binding 1469047 FASCIN O94856 Q810U3 CellAdhesion Membrane ANKYRIN P16157 Q02357 Cytoskeleton Cytosol 0 Binding 7961622 CRMP2 Q16555 P47942 Activator Cytosol TUBULIN P05209 P05209 Cytoskeleton Cytosol + Binding 12134159 TAU P10636 P20357 Activator Cytosol TUBULIN P05209 P05209 Cytoskeleton Cytosol 0 Binding 1421571 PKC P17252 P05697 Kinase Cytosol EIF4E P06730 P20415 Adapter Ribosomes + Phosphorylation 2355012 PKC P17252 P05697 Kinase Cytosol EIF4E P06730 P20415 Adapter Ribosomes + Phosphorylation 1911648 RSK Q15418 P18653 Kinase Cytosol S6 NA NA Adapter Ribosomes + Phosphorylation 2138782 S6 NA NA Adapter Ribosomes S40 NA NA Ribosome Ribosomes + Binding 947902 SRP54 P61011 P14576 Adapter Ribosomes NASCENTCHAIN NA NA Peptide Ribosomes + Binding 12913112 SRP54 P61011 P14576 Adapter Ribosomes NASCENTCHAIN NA NA Peptide Ribosomes + Binding 2502718 SRP54 P61011 P14576 Adapter Ribosomes SRPR P08240 Q9DBG7 Receptor ER + Binding 12913112 SRPR P08240 Q9DBG7 Receptor ER SEC61P P61620 P61621 Channel ER + Binding 12913112 S60 NA NA Ribosome Ribosomes SRP54 P61011 P14576 Adapter Ribosomes + GEF 12913112 PERK Q9NZJ5 Q9Z2B5 Kinase Cytosol EIF2 P05198 P05199 Ribosome Ribosomes + Phosphorylation 9930704 PKR Q8TCW9 Q9JKL1 Kinase Cytosol EIF2 P05198 P05199 Ribosome Ribosomes _ Phosphorylation 3479429 PKR Q8TCW9 Q9JKL1 Kinase Cytosol EIF2 P05198 P05199 Ribosome Ribosomes _ Phosphorylation 10866685 EIF2 P05198 P05199 Ribosome Ribosomes tRNA NA NA RNA Ribosomes 0 Binding 863906 EIF2 P05198 P05199 Ribosome Ribosomes tRNA NA NA RNA Ribosomes 0 Binding 833127 S40 NA NA Ribosome Ribosomes mRNA NA NA RNA Ribosomes 0 Binding 5341323 S40 NA NA Ribosome Ribosomes mRNA NA NA RNA Ribosomes 0 Binding 4909872 S40 NA NA Ribosome Ribosomes S60 NA NA Ribosome Ribosomes 0 Binding 4909872 S40 NA NA Ribosome Ribosomes S60 NA NA Ribosome Ribosomes 0 Binding 4856634 S40 NA NA Ribosome Ribosomes S60 NA NA Ribosome Ribosomes 0 Binding 14270536 EIF4E P06730 P20415 Adapter Ribosomes mRNA NA NA RNA Ribosomes 0 Binding 217002 EIF4G P78344 Q8VE62 Ribosome Ribosomes mRNA NA NA RNA Ribosomes 0 Binding 3804998 EIF3 O75822 O75822 Ribosome Ribosomes mRNA NA NA RNA Ribosomes 0 Binding 6906354 EIF4A P60843 P60842 Ribosome Ribosomes mRNA NA NA RNA Ribosomes 0 Binding 3707129 EIF4A P60843 P60842 Ribosome Ribosomes mRNA NA NA RNA Ribosomes 0 Binding 6579543 EIF4G P78344 Q8VE62 Ribosome Ribosomes DCP1 P12821 P22967 Ribosome Ribosomes 0 Binding 10944120 EIF4G P78344 Q8VE62 Ribosome Ribosomes EIF4E P06730 P20415 Adapter Ribosomes 0 Binding 10944120 EIF4G P78344 Q8VE62 Ribosome Ribosomes PABP P11940 P29341 Adapter Ribosomes 0 Binding 10944120 EIF4G P78344 Q8VE62 Ribosome Ribosomes PABP P11940 P29341 Ribosome Ribosomes 0 Binding 9195926 EIF4G P78344 Q8VE62 Ribosome Ribosomes MNK1 Q9BXL6 Q99KF0 Kinase Cytosol 0 Binding 9878069 S6K P23443 Q9Z1M4 Kinase Cytosol S6 NA NA Adapter Ribosomes + Phosphorylation 6325456 CASPASE3 P42574 P70677 Protease Cytosol EIF4G P78344 Q8VE62 Ribosome Ribosomes _ Cleavage 10371215 PKR Q8TCW9 Q9JKL1 Kinase Cytosol EIF2 P05198 P05199 Ribosome Ribosomes _ Phosphorylation 7890757 PKR Q8TCW9 Q9JKL1 Kinase Cytosol EIF2 P05198 P05199 Ribosome Ribosomes _ Phosphorylation 11555640 EIF5 P55010 P59325 Ribosome Ribosomes EIF2 P05198 P05199 Ribosome Ribosomes + Binding 9395514 DCP1 P12821 P22967 Ribosome Ribosomes mRNA NA NA RNA Ribosomes _ Cleavage 8757137 DCP1 P12821 P22967 Ribosome Ribosomes mRNA NA NA RNA Ribosomes _ Cleavage 9482745 CALNEXIN P27824 P35564 Chaperone ER NASCENTCHAIN NA NA Peptide Ribosomes 0 Binding 8486646 CALRETICULIN P27797 P14211 Chaperone ER NASCENTCHAIN NA NA Peptide Ribosomes 0 Binding 7657600 BIP P11021 P08109 Chaperone ER NASCENTCHAIN NA NA Peptide Ribosomes 0 Binding 3084497 GRP94 P14625 P08113 Chaperone ER NASCENTCHAIN NA NA Peptide Ribosomes 0 Binding 1400441 GRP94 P14625 P08113 Chaperone ER NASCENTCHAIN NA NA Peptide Ribosomes 0 Binding 2944601 PDI Q9ULC6 Q9Z185 Chaperone ER NASCENTCHAIN NA NA Peptide Ribosomes + Binding 812800 DNAJ P31689 P54102 Chaperone ER NASCENTCHAIN NA NA Peptide Ribosomes 0 Binding 2005967 DNAJ P31689 P54102 Chaperone ER NASCENTCHAIN NA NA Peptide Ribosomes 0 Binding 9585179 PHAS Q13541 P70445 Inhibitor Ribosomes EIF4E P06730 P20415 Adapter Ribosomes _ Binding 7935836 EIF3 O75822 O75822 Ribosome Ribosomes EIF4G P78344 Q8VE62 Ribosome Ribosomes + Binding 11022043 S40 NA NA Ribosome Ribosomes EIF3 O75822 O75822 Ribosome Ribosomes 0 Binding 6414530 EIF4A P60843 P60842 Ribosome Ribosomes EIF4G P78344 Q8VE62 Ribosome Ribosomes 0 Binding 9372926 PP2A Q13362 Q80W65 Phosphatase Cytosol GSK3 P49840 Q9WV60 Kinase Cytosol + Dephosphorylation 11897496 PP2A Q13362 Q80W65 Phosphatase Cytosol PKB P31749 Q60823 Kinase Cytosol _ Dephosphorylation 11897496 CALCINEURIN P06705 P61023 Phosphatase Cytosol TAU P10636 P20357 Activator Cytosol _ Dephosphorylation 12064514 CALCINEURIN P06705 P61023 Phosphatase Cytosol TAU P10636 P20357 Activator Cytosol _ Dephosphorylation 8720139 SIVA1 O15304 P02798 Adapter Cytosol BCLXL Q07817 P70345 Bcl2Family Mitochondria _ Binding 14739602 CALBRAIN Q9NZU7 Q9JLK7 Inhibitor Cytosol CAMKII Q9UQM7 P11798 Kinase Cytosol _ Binding 9920909 CALMODULIN P62158 P62204 Activator Cytosol AKAP P24588 Q9JL25 Adapter Cytosol _ Binding 9202019 CALMODULIN P62158 P62204 Activator Cytosol RAS P01111 P08556 GTPase Cytosol _ Binding 11585916 CALMODULIN P62158 P62204 Activator Cytosol VAMP Q9P0L0 Q9WV55 Vesicle Vesicles _ Binding 10944231 PKC P17252 P05697 Kinase Cytosol bARK P25098 O70293 Kinase Cytosol _ Phosphorylation 9013639 CALMODULIN P62158 P62204 Activator Cytosol bARK P25098 O70293 Kinase Cytosol _ Binding 11042191 DENSIN Q15003 Q9JI18 Adapter Cytosol NMDAR Q12879 P35436 Receptor Membrane 0 Binding 10827168 GRB2 P62993 Q60631 Adapter Cytosol PTPA P18433 P18052 Phosphatase Cytosol _ Binding 8670803 BETAARRESTIN P49407 Q91YI4 Adapter Cytosol CLATHRIN P09496 O08585 Vesicle Vesicles 0 Binding 10770944 BETAARRESTIN P49407 Q91YI4 Adapter Cytosol AP2 P53680 P61966 Adapter Vesicles 0 Binding 10770944 GABABR Q9UBS5 Q8K452 Receptor Membrane GALPHAO P09471 P18872 Gprotein Cytosol + Binding 12917685 GABABR Q9UBS5 Q8K452 Receptor Membrane GBETAGAMMA P11016 P11016 Gprotein Cytosol + Binding 11416164 EIF1A O75642 P47813 Ribosome Ribosomes S40 NA NA Ribosome Ribosomes 0 Binding 12860115 EIF4B P23588 Q9WUK2 Ribosome Ribosomes mRNA NA NA RNA Ribosomes 0 Binding 6712925 EIF4A P60843 P60842 Ribosome Ribosomes EIF4G P78344 Q8VE62 Ribosome Ribosomes 0 Binding 10480875 CBP Q92793 P45481 TF Nucleus EIF4G P78344 Q8VE62 Ribosome Ribosomes 0 Binding 15059963 PABP P11940 P29341 Ribosome Ribosomes mRNA NA NA RNA Ribosomes 0 Binding 3537727 PKC P17252 P05697 Kinase Cytosol MGLUR1 Q13255 P97772 Receptor Membrane + Phosphorylation 15305863 PDE1A P54750 Q61481 PDE Cytosol cGMP NA NA Messenger Cytosol _ PDE 7678006 PDE1A P54750 Q61481 PDE Cytosol cGMP NA NA Messenger Cytosol _ PDE 1326531 PDE1A P54750 Q61481 PDE Cytosol cGMP NA NA Messenger Cytosol _ PDE 8537356 CALMODULIN P62158 P62204 Activator Cytosol PDE1A P54750 Q61481 PDE Cytosol + Binding 3021730 PDE1B Q01064 Q01064 PDE Cytosol cGMP NA NA Messenger Cytosol _ PDE 7678006 PDE1B Q01064 Q01064 PDE Cytosol cGMP NA NA Messenger Cytosol _ PDE 1326531 PDE1B Q01064 Q01064 PDE Cytosol cGMP NA NA Messenger Cytosol _ PDE 8537356 CALMODULIN P62158 P62204 Activator Cytosol PDE1B Q01064 Q01064 PDE Cytosol + Binding 3021730 PDE1C Q14123 Q64338 PDE Cytosol cGMP NA NA Messenger Cytosol _ PDE 15082510 CALMODULIN P62158 P62204 Activator Cytosol PDE1C Q14123 Q64338 PDE Cytosol + Binding 15082510 PDE2A O00408 Q922S4 PDE Cytosol cAMP NA NA Messenger Cytosol _ PDE 7811274 cGMP NA NA Messenger Cytosol PDE2A O00408 Q922S4 PDE Cytosol + Binding 7811274 cGMP NA NA Messenger Cytosol PDE3A Q14432 Q9Z0X4 PDE Cytosol _ Binding 7870041 cGMP NA NA Messenger Cytosol PDE3B Q13370 Q61409 PDE Cytosol _ Binding 7870041 PDE3A Q14432 Q9Z0X4 PDE Cytosol cAMP NA NA Messenger Cytosol _ PDE 8395509 PDE3B Q13370 Q61409 PDE Cytosol cAMP NA NA Messenger Cytosol _ PDE 8395509 PKA P17612 P05132 Kinase Cyosol PDE3A Q14432 Q9Z0X4 PDE Cytosol + Phosphorylation 2839485 PKA P17612 P05132 Kinase Cyosol PDE3B Q13370 Q61409 PDE Cytosol + Phosphorylation 2839485 PDE4A P27815 O89084 PDE Cytosol cAMP NA NA Messenger Cytosol _ PDE 7702577 PDE4A P27815 O89084 PDE Cytosol cAMP NA NA Messenger Cytosol _ PDE 2542941 PDE4B Q07343 P14646 PDE Cytosol cAMP NA NA Messenger Cytosol _ PDE 2542941 PDE4B Q07343 P14646 PDE Cytosol cAMP NA NA Messenger Cytosol _ PDE 7998974 PDE4C Q08493 P14644 PDE Cytosol cAMP NA NA Messenger Cytosol _ PDE 9429761 PDE4D Q08499 Q01063 PDE Cytosol cAMP NA NA Messenger Cytosol _ PDE 9371713 PKA P17612 P05132 Kinase Cyosol PDE4D Q08499 Q01063 PDE Cytosol + Phosphorylation 15082510 PKG Q13237 Q9Z0Z0 Kinase Cyosol PDE5A O76074 Q8CG03 PDE Cytosol + Phosphorylation 15082510 PKA P17612 P05132 Kinase Cyosol PDE5A O76074 Q8CG03 PDE Cytosol + Phosphorylation 15082510 PDE5A O76074 Q8CG03 PDE Cytosol cGMP NA NA Messenger Cytosol _ PDE 15082510 BETAARRESTIN P49407 Q91YI4 Adapter Cytosol PDE4D Q08499 Q01063 PDE Cytosol + Binding 12399592 BETAARRESTIN P49407 Q91YI4 Adapter Cytosol PDE4D Q08499 Q01063 PDE Cytosol + Binding 12552097 PKA P17612 P05132 Kinase Cytosol NMDAR Q12879 P35436 Receptor Membrane + Phosphorylation 9115280 PKC P17252 P05697 Kinase Cytosol NMDAR Q12879 P35436 Receptor Membrane _ Phosphorylation 9115280 GALPHA11 P29992 P21279 Gprotein Cytosol PLCBETA Q9NQ66 P51432 Phospholipase Cytosol + Binding 12578375 PA NA NA Messenger Cytosol PLCBETA Q9NQ66 P51432 Phospholipase Cytosol + Binding 12578375 CBL Q13191 P22682 Ubiquitinase Cytosol CRK P46108 Q64010 Adapter Cytosol _ Binding 8626404 CBL Q13191 P22682 Ubiquitinase Cytosol CRK P46108 Q64010 Adapter Cytosol _ Binding 12697763 CBL Q13191 P22682 Ubiquitinase Cytosol GRB2 P62993 Q60631 Adapter Cytosol _ Ubiquitination 8626404 CBL Q13191 P22682 Ubiquitinase Cytosol FYN P06241 P39688 Kinase Cytosol _ Binding 8083187 CBL Q13191 P22682 Ubiquitinase Cytosol FYN P06241 P39688 Kinase Cytosol _ Binding 15208330 CBL Q13191 P22682 Ubiquitinase Cytosol LCK P06239 P08103 Kinase Cytosol _ Binding 8083187 CBL Q13191 P22682 Ubiquitinase Cytosol LCK P06239 P08103 Kinase Cytosol _ Binding 11904433 CDC42 P60953 P60766 GTPase Cytosol MLK3 Q02779 Q60700 Kinase Cytosol + Binding 10799501 RAC P15154 P15154 GTPase Cytosol MLK3 Q02779 Q60700 Kinase Cytosol + Binding 10799501 JNK P45983 Q91Y86 Kinase Nucleus ATF2 P15336 Q60765 TF Nucleus + Phosphorylation 7824938 SYNGAP Q96PV0 Q60790 GEF Cytosol RAS P01111 P08556 GTPase Cytosol _ GAP 9581761 CAMKII Q9UQM7 P11798 Kinase Cytosol SYNGAP Q96PV0 Q60790 GEF Cytosol _ Phosphorylation 9620694 RASGAP Q8IV61 Q91ZC8 GAP Cytosol RAS P01111 P08556 GTPase Cytosol _ GAP 2833817 RASGAP Q8IV61 Q91ZC8 GAP Cytosol PKB P31749 Q60823 Kinase Cytosol + Binding 14707121 ILK Q13418 O55222 Kinase Cytosol PKB P31749 Q60823 Kinase Cytosol + Phosphorylation 9736715 ILK Q13418 O55222 Kinase Cytosol GSK3 P49840 Q9WV60 Kinase Cytosol _ Phosphorylation 9736715 CAMKK Q96RP1 Q9R054 Kinase Cytosol CAMKI Q14012 Q91YS8 Kinase Cytosol + Phosphorylation 8631893 CAMKK Q96RP1 Q9R054 Kinase Cytosol CAMKIV Q16566 P08414 Kinase Cytosol + Phosphorylation 8631893 CAMKK Q96RP1 Q9R054 Kinase Cytosol CAMKI Q14012 Q91YS8 Kinase Cytosol + Phosphorylation 7642608 CAMKK Q96RP1 Q9R054 Kinase Cytosol CAMKIV Q16566 P08414 Kinase Cytosol + Phosphorylation 7642608 CAMKK Q96RP1 Q9R054 Kinase Cytosol PKB P31749 Q60823 Kinase Cytosol + Phosphorylation 9859994 CAMKIV Q16566 P08414 Kinase Cytosol CREB P16220 Q01147 TF Nucleus + Phosphorylation 7958915 CAMKII Q9UQM7 P11798 Kinase Cytosol CREB P16220 Q01147 TF Nucleus + Phosphorylation 7958915 CAMKK Q96RP1 Q9R054 Kinase Cytosol CAMKI Q14012 Q91YS8 Kinase Cytosol + Phosphorylation 10400638 CAMKIV Q16566 P08414 Kinase Cytosol SYNAPSIN P17600 O88935 Vesicle Vesicles + Phosphorylation 10400638 CHOLESTEROL NA NA Lipid Membrane SYNAPTOPHYSIN P08247 Q8BGN8 Vesicle Vesicles + Binding 12485399 MUNC13 O14795 Q9Z1N9 Vesicle Vesicles SYNTAXIN Q13277 O35526 Vesicle Vesicles + Binding 8999968 COMPLEXIN O14810 Q64276 Vesicle Vesicles SYNTAXIN Q13277 O35526 Vesicle Vesicles 0 Binding 7553862 COMPLEXIN O14810 Q64276 Vesicle Vesicles SNAP25 P60878 P60881 Vesicle Vesicles 0 Binding 7553862 SNAPIN P60878 P60881 Vesicle Vesicles AC5 O95622 Q01341 Cyclase Membrane + Binding 15319443 SNAPIN P60878 P60881 Vesicle Vesicles SNAP25 P60878 P60881 Vesicle Vesicles _ Binding 10195194 CASK Q9HCP0 Q8BTH8 Kinase Cytosol SYNTAXIN Q13277 O35526 Vesicle Vesicles + Phosphorylation 11846792 PKA P17612 P05132 Kinase Cytosol SNAPIN P60878 P60881 Vesicle Vesicles + Phosphorylation 15269257 PKI P61925 P27776 Inhibitor Cytosol PKA P17612 P05132 Kinase Cytosol _ Binding 1770951 DYRK Q13627 Q61214 Kinase Cytosol EIF2 P05198 P05199 Ribosome Ribosomes _ Phosphorylation 11311121 DYRK Q13627 Q61214 Kinase Cytosol TAU P10636 P20357 Activator Cytosol _ Phosphorylation 11311121 PP2A Q13362 Q80W65 Phosphatase Cytosol CAS P56945 Q61140 Adapter Cytosol _ Dephosphorylation 11593413 GSK3 P49840 Q9WV60 Kinase Cytosol INHIBITOR2 P05120 P12388 Inhibitor Cytosol + Phosphorylation 6090457 CASK Q9HCP0 Q8BTH8 Kinase Cytosol INHIBITOR2 P05120 P12388 Inhibitor Cytosol + Phosphorylation 6090457 GSK3 P49840 Q9WV60 Kinase Cytosol INHIBITOR2 P05120 P12388 Inhibitor Cytosol + Phosphorylation 6091765 INHIBITOR2 P05120 P12388 Inhibitor Cytosol PP1 P36873 P37139 Phosphatase Cytosol _ Binding 6327437 SHP1 Q96B97 Q9JLQ0 Phosphatase Cytosol ALPHAACTININ Q08043 O88990 Cytoskeletal Cytosol _ Dephosphorylation 15070900 SHP1 Q96B97 Q9JLQ0 Phosphatase Cytosol SPROUTY O43609 Q9QXV9 Adapter Cytosol _ Dephosphorylation 15031289 PTP1B P18031 P35821 Phosphatase Cytosol IR P06213 P15208 Receptor Membrane _ Dephosphorylation 14722096 PP5 P53041 Q60676 Phosphatase Cytosol TAU P10636 P20357 Activator Cytosol _ Dephosphorylation 14690518 CAMKPASE P49593 P36993 Phosphatase Cytosol CaMKI Q14012 Q91YS8 Kinase Cytosol _ Dephosphorylation 9442023 CAMKPASE P49593 P36993 Phosphatase Cytosol CaMKI Q14012 Q91YS8 Kinase Cytosol _ Dephosphorylation 10814834 CAMKPASE P49593 P36993 Phosphatase Cytosol CAMKII Q9UQM7 P11798 Kinase Cytosol _ Dephosphorylation 10814834 CAMKPASE P49593 P36993 Phosphatase Cytosol CAMKIV Q16566 P08414 Kinase Cytosol _ Dephosphorylation 10814834 PP1 P36873 P37139 Phosphatase Cytosol NMDAR Q12879 P35436 Receptor Membrane _ Dephosphorylation 8183343 PP2A Q13362 Q80W65 Phosphatase Cytosol NMDAR Q12879 P35436 Receptor Membrane _ Dephosphorylation 8183343 NMDAR Q12879 P35436 Receptor Membrane CAMKII Q9UQM7 P11798 Kinase Cytosol 0 Binding 10077668 CALMODULIN P62158 P62204 Activator Cytosol NMDAR Q12879 P35436 Receptor Membrane _ Binding 9728925 NMDAR Q12879 P35436 Receptor Membrane ALPHAACTININ Q08043 O88990 Cytoskeletal Cytosol 0 Binding 9728925 SYNTAXIN Q13277 O35526 Vesicle Vesicles MUNC18 P61763 P61765 Vesicle Vesicles 0 Binding 8108429 NMDAR Q12879 P35436 Receptor Membrane PSD95 P78352 Q62108 Adapter Cytosol 0 Binding 12399578 NMDAR Q12879 P35436 Receptor Membrane PSD95 P78352 Q62108 Adapter Cytosol 0 Binding 7569905 PSD95 P78352 Q62108 Adapter Cytosol NOS P29475 Q9Z0J4 Synthase Cytosol 0 Binding 11031113 PP1 P36873 P37139 Phosphatase Cytosol CAMKII Q9UQM7 P11798 Kinase Cytosol _ Dephosphorylation 12928489 PP1 P36873 P37139 Phosphatase Cytosol CAMKII Q9UQM7 P11798 Kinase Cytosol _ Dephosphorylation 8753794 PKA P17612 P05132 Kinase Cytosol I1 Q13522 Q9ERT9 Inhibitor Cytosol _ Phosphorylation 8611507 I1 Q13522 Q9ERT9 Inhibitor Cytosol PP1 P36873 P37139 Phosphatase Cytosol _ Binding 8611507 I1 Q13522 Q9ERT9 Inhibitor Cytosol PP1 P36873 P37139 Phosphatase Cytosol _ Binding 9765309 CALCINEURIN P06705 P61023 Phosphatase Cytosol SYNAPSIN P17600 O88935 Vesicle Vesicles _ Dephosphorylation 6330098 PKC P17252 P05697 Kinase Cytosol GSK3 P49840 Q9WV60 Kinase Cytosol _ Phosphorylation 1324914 PKC P17252 P05697 Kinase Cytosol GSK3 P49840 Q9WV60 Kinase Cytosol _ Phosphorylation 14556709 IQGAP P46940 Q9JKF1 GAP Cytosol BETACATENIN P35222 Q02248 TF Cytosol 0 Binding 9694656 IQGAP P46940 Q9JKF1 GAP Cytosol BETACATENIN P35222 Q02248 TF Cytosol 0 Binding 10473551 IQGAP P46940 Q9JKF1 GAP Cytosol CDC42 P60953 P60766 GTPase Cytosol 0 Binding 8798539 IQGAP P46940 Q9JKF1 GAP Cytosol RAC P15154 P15154 GTPase Cytosol 0 Binding 8798539 IQGAP P46940 Q9JKF1 GAP Cytosol CDC42 P60953 P60766 GTPase Cytosol 0 Binding 9199170 IQGAP P46940 Q9JKF1 GAP Cytosol RAC P15154 P15154 GTPase Cytosol 0 Binding 9199170 PTPA P18433 P18052 Phosphatase Cytosol FYN P06241 P39688 Kinase Cytosol + Dephosphorylation 9535845 PTPA P18433 P18052 Phosphatase Cytosol FYN P06241 P39688 Kinase Cytosol + Dephosphorylation 10562275 PTPA P18433 P18052 Phosphatase Cytosol SRC P12931 P05480 Kinase Cytosol + Dephosphorylation 9535845 PTPA P18433 P18052 Phosphatase Cytosol LCK P06239 P08103 Kinase Cytosol + Dephosphorylation 9535845 PKC P17252 P05697 Kinase Cytosol SNAP25 P60878 P60881 Vesicle Vesicles _ Phosphorylation 15277518 PKC P17252 P05697 Kinase Cytosol SNAP25 P60878 P60881 Vesicle Vesicles _ Phosphorylation 12417653 CDK5 Q00535 P49615 Kinase Cytosol MUNC18 P61763 P61765 Vesicle Vesicles _ Phosphorylation 9478941 SYNTAXIN Q13277 O35526 Vesicle Vesicles MUNC18 P61763 P61765 Vesicle Vesicles 0 Binding 9478941 CDK5 Q00535 P49615 Kinase Cytosol SYNTAXIN Q13277 O35526 Vesicle Vesicles 0 Binding 9478941 CDK5 Q00535 P49615 Kinase Cytosol MUNC18 P61763 P61765 Vesicle Vesicles _ Phosphorylation 9933594 SYNTAXIN Q13277 O35526 Vesicle Vesicles MUNC18 P61763 P61765 Vesicle Vesicles 0 Binding 9933594 PKC P17252 P05697 Kinase Cytosol MUNC18 P61763 P61765 Vesicle Vesicles _ Phosphorylation 10651895 CAMKII Q9UQM7 P11798 Kinase Cytosol VAMP Q9P0L0 Q9WV55 Vesicle Vesicles 0 Phosphorylation 8876242 CAMKII Q9UQM7 P11798 Kinase Cytosol SYNTAXIN Q13277 O35526 Vesicle Vesicles _ Binding 11978810 CASPASE3 P42574 P70677 Protease Cytosol PIP5K P48426 Q80XI4 Kinase Cytosol _ Cleavage 11042212 PIP2 NA NA Lipid Cytosol GELSOLIN P06396 P13020 Cytoskeleton Cytosol + Binding 11042212 PIP2 NA NA Lipid Cytosol CASPASE3 P42574 P70677 Protease Cytosol _ Binding 11042212 PIP2 NA NA Lipid Cytosol CASPASE8 Q14790 O89110 Protease Cytosol _ Binding 11042212 PIP2 NA NA Lipid Cytosol CASPASE9 P55211 Q9R0T0 Protease Cytosol _ Binding 11042212 P1433 Q04917 P11576 Adapter Cytosol KSR O95381 Q8VC98 Kinase Cytosol 0 Binding 10643560 P1433 Q04917 P11576 Adapter Cytosol KSR O95381 Q8VC98 Kinase Cytosol 0 Binding 9115393 KSR O95381 Q8VC98 Kinase Cytosol MEK1 Q92918 Q8BPM2 Kinase Cytosol 0 Binding 10891492 KSR O95381 Q8VC98 Kinase Cytosol MAPK P28482 P27703 Kinase Cytosol 0 Binding 10891492 KSR O95381 Q8VC98 Kinase Cytosol RAF1 P04049 Q99N57 Kinase Cytosol + Binding 9115393 bARK P25098 O70293 Kinase Cytosol MOR P35372 P33534 Receptor Cytosol _ Phosphorylation 10488100 bARK P25098 O70293 Kinase Cytosol MOR P35372 P33534 Receptor Cytosol _ Phosphorylation 11861651 BETAARRESTIN P49407 Q91YI4 Adapter Cytosol MOR P35372 P33534 Receptor Cytosol _ Binding 11861651 CALCIUM NA NA Messenger Cytosol SV2A Q9BVZ9 Q9Z0E8 Vesicle Vesicles _ Binding 8910372 PKC P17252 P05697 Kinase Cytosol BCL2 P10415 Q64373 Bcl2Family Mitochondria _ Phosphorylation 9738012 GSK3 P49840 Q9WV60 Kinase Cytosol AP1 P05412 P05627 TF Nucleus _ Phosphorylation 1846781 GSK3 P49840 Q9WV60 Kinase Cytosol TAU P10636 P20357 Activator Cytosol _ Phosphorylation 8228990 RAF1 P04049 Q99N57 Kinase Cytosol BAD Q92934 Q61337 Bcl2Family Mitochondria _ Phosphorylation 8929532 BAD Q92934 Q61337 Bcl2Family Mitochondria BCLXL Q07817 P70345 Bcl2Family Mitochondria + Binding 8929531 PKA P17612 P05132 Kinase Cytosol BAD Q92934 Q61337 Bcl2Family Mitochondria _ Phosphorylation 10880354 PP2C P35813 P49443 Phosphatase Cytosol BAD Q92934 Q61337 Bcl2Family Mitochondria + Dephosphorylation 12590938 PP2A Q13362 Q80W65 Phosphatase Cytosol BAD Q92934 Q61337 Bcl2Family Mitochondria + Dephosphorylation 11222372 PP1 P36873 P37139 Phosphatase Cytosol BCL2 P10415 Q64373 Bcl2Family Mitochondria + Dephosphorylation 12051739 PKB P31749 Q60823 Kinase Cytosol CASPASE9 P55211 Q9R0T0 Protease Cytosol _ Phosphorylation 9812896 GEPHYRIN Q9NQX3 Q8BUV3 Adapter Membrane GLYR P23415 Q61603 Receptor Membrane 0 Binding 14976213 SAM68 Q8TCZ4 Q64213 Adapter Cytosol CBP Q92793 P45481 TF Nucleus _ Binding 12496368 DREAM Q9Y2W7 Q9QXT8 TF Nucleus DRE NA NA DNA Nucleus _ Binding 11108959 NMDAR Q12879 P35436 Receptor Membrane YOTIAO Q99996 Q91VW5 Adapter Cytosol 0 Binding 9482789 PKA P17612 P05132 Kinase Cytosol YOTIAO Q99996 Q91VW5 Adapter Cytosol 0 Binding 10390370 YOTIAO Q99996 Q91VW5 Adapter Cytosol PP1 P36873 P37139 Phosphatase Cytosol 0 Binding 10390370 CALCIUM NA NA Messenger Cytosol SYNAPTOTAGMIN P21579 P46096 Vesicle Vesicles + Binding 8253763 SYNAPTOTAGMIN P21579 P46096 Vesicle Vesicles SYNTAXIN Q13277 O35526 Vesicle Vesicles + Binding 1321498 SYNAPTOTAGMIN P21579 P46096 Vesicle Vesicles SNAP25 P60878 P60881 Vesicle Vesicles 0 Binding 1470954 SYNTAXIN Q13277 O35526 Vesicle Vesicles SNAP25 P60878 P60881 Vesicle Vesicles 0 Binding 7957071 SNAP25 P60878 P60881 Vesicle Vesicles SYNAPTOBREVIN P23763 Q62442 Vesicle Vesicles 0 Binding 7961655 SYNTAXIN Q13277 O35526 Vesicle Vesicles SYNAPTOBREVIN P23763 Q62442 Vesicle Vesicles 0 Binding 8108733 RAL P11233 P05810 GTPase Cytosol RALBP1 Q15311 Q62172 GAP Cytosol + Binding 10393179 ARIP2 NA Q8K4F3 Adapter Cytosol RALBP1 Q15311 Q62172 GAP Cytosol 0 Binding 11882656 AKAP15 NA P70593 Adapter Cytosol PKA P17612 P05132 Kinase Cytosol 0 Binding 9620705 AKAP15 NA P70593 Adapter Cytosol LTYPECA Q13936 Q13936 Channel Membrane 0 Binding 9620705 GKAP O14490 P97836 Adapter Cytosol SHANK Q9Y566 P31695 Adapter Cytosol 0 Binding 10433268 REELIN P78509 Q60841 Ligand Extracellular INTEGRIN P05556 P09055 CellAdhesion Membrane _ Binding 10725376 REELIN P78509 Q60841 Ligand Extracellular INTEGRIN P05556 P09055 CellAdhesion Membrane _ Binding 10939329 PKC P17252 P05697 Kinase Cytosol PMCA P20020 Q9R0K7 Pump Membrane _ Phosphorylation 11779484 PKC P17252 P05697 Kinase Cytosol PMCA P20020 Q9R0K7 Pump Membrane _ Phosphorylation 9824678 PKA P17612 P05132 Kinase Cytosol PMCA P20020 Q9R0K7 Pump Membrane _ Phosphorylation 9824678 PKA P17612 P05132 Kinase Cytosol STEP P54829 P54830 Phosphatase Cytosol _ Phosphorylation 10908600 CALCINEURIN P06705 P61023 Phosphatase Cytosol STEP P54829 P54830 Phosphatase Cytosol + Dephosphorylation 12483215 STEP P54829 P54830 Phosphatase Cytosol MAPK P28482 P27703 Kinase Cytosol _ Dephosphorylation 9857190 CASPASE7 P55210 P97864 Protease Cytosol MEF2 Q02080 O55087 TF Nucleus _ Cleavage 11904443 CASPASE3 P42574 P70677 Protease Cytosol MEF2 Q02080 O55087 TF Nucleus _ Cleavage 11904443 SRC P12931 P05480 Kinase Cytosol SPECTRIN O15020 Q62261 Cytoskeleton Cytosol + Phosphorylation 12446661 CALPAIN P07384 O35350 Protease Cytosol SPECTRIN O15020 Q62261 Cytoskeleton Cytosol _ Cleavage 12446661 FYN P06241 P39688 Kinase Cytosol AMPAR P42261 P23818 Channel Membrane + Phosphorylation 11677266 CALPAIN P07384 O35350 Protease Cytosol AMPAR P42261 P23818 Channel Membrane _ Cleavage 11677266 SRC P12931 P05480 Kinase Cytosol NMDAR Q12879 P35436 Receptor Membrane + Phosphorylation 10846184 CALPAIN P07384 O35350 Protease Cytosol NMDAR Q12879 P35436 Receptor Membrane _ Cleavage 10846184 PKC P17252 P05697 Kinase Cytosol LTYPECA Q13936 Q13936 Channel Membrane _ Phosphorylation 11035786 PKA P17612 P05132 Kinase Cytosol LTYPECA Q13936 Q13936 Channel Membrane _ Phosphorylation 10984483 PKA P17612 P05132 Kinase Cytosol LTYPECA Q13936 Q13936 Channel Membrane _ Phosphorylation 2174428 PP2A Q13362 Q80W65 Phosphatase Cytosol LTYPECA Q13936 Q13936 Channel Membrane + Dephosphorylation 10984483 PKA P17612 P05132 Kinase Cytosol LTYPECA Q13936 Q13936 Channel Membrane _ Phosphorylation 10514522 MAP2 P11137 P20357 Cytoskeleton Cytosol LTYPECA Q13936 Q13936 Channel Membrane 0 Binding 10514522 CASPASE3 P42574 P70677 Protease Cytosol PARP P09874 P11103 Polymerase Cytosol _ Cleavage 10438458 PKC P17252 P05697 Kinase Cytosol IRS1 P35568 P35569 Adapter Cytosol _ Phosphorylation 15069075 CAMKII Q9UQM7 P11798 Kinase Cytosol RICS Q9BWG3 Q91V57 Adapter Cytosol _ Phosphorylation 12531901 RACK P25388 P25388 Adapter Cytosol NMDAR Q12879 P35436 Receptor Membrane 0 Binding 11943848 RACK P25388 P25388 Adapter Cytosol FYN P06241 P39688 Kinase Cytosol _ Binding 11943848 NAKED Q96969 O88706 Antagonist Cytosol FRIZZLED Q9UP38 O70421 Receptor Membrane _ Binding 12354775 INHIBITOR2 P05120 P12388 Inhibitor Cytosol PP1 P36873 P37139 Phosphatase Cytosol _ Binding 11812771 INHIBITOR2 P05120 P12388 Inhibitor Cytosol PP1 P36873 P37139 Phosphatase Cytosol _ Binding 11320080 PP2A Q13362 Q80W65 Phosphatase Cytosol CREB P16220 Q01147 TF Nucleus _ Dephosphorylation 8386317 PKC P17252 P05697 Kinase Cytosol GABAAR P14867 P18504 Receptor Membrane _ Phosphorylation 11517239 PKC P17252 P05697 Kinase Cytosol PLCBETA Q9NQ66 P51432 Phospholipase Cytosol _ Phosphorylation 9015864 PKA P17612 P05132 Kinase Cytosol PLCBETA Q9NQ66 P51432 Phospholipase Cytosol _ Phosphorylation 8657310 PKC P17252 P05697 Kinase Cytosol PLCBETA Q9NQ66 P51432 Phospholipase Cytosol _ Phosphorylation 2211670 PKC P17252 P05697 Kinase Cytosol PLCBETA Q9NQ66 P51432 Phospholipase Cytosol _ Phosphorylation 9307019 PKA P17612 P05132 Kinase Cytosol PLCBETA Q9NQ66 P51432 Phospholipase Cytosol _ Phosphorylation 9660757 PKC P17252 P05697 Kinase Cytosol DGK Q16854 Q9QX60 Kinase Cytosol _ Phosphorylation 12890670 PKC P17252 P05697 Kinase Cytosol DGK Q16854 Q9QX60 Kinase Cytosol _ Phosphorylation 9716136 PKB P31749 Q60823 Kinase Cytosol FORKHEAD Q12778 Q9R1E0 TF Nucleus _ Phosphorylation 10102273 PKB P31749 Q60823 Kinase Cytosol FORKHEAD Q12778 Q9R1E0 TF Nucleus _ Phosphorylation 10358075 PKB P31749 Q60823 Kinase Cytosol P53 Q12888 P70399 TF Nucleus _ Phosphorylation 11054421 PKB P31749 Q60823 Kinase Cytosol BAD Q92934 Q61337 Bcl2Family Mitochondria _ Phosphorylation 9346240 PKB P31749 Q60823 Kinase Cytosol BAD Q92934 Q61337 Bcl2Family Mitochondria _ Phosphorylation 9381178 BAD Q92934 Q61337 Bcl2Family Mitochondria BCL2 P10415 Q64373 Bcl2Family Mitochondria + Binding 7834748 BAD Q92934 Q61337 Bcl2Family Mitochondria BCL2 P10415 Q64373 Bcl2Family Mitochondria + Binding 9388232 BAX Q07812 Q07813 Bcl2Family Mitochondria BAD Q92934 Q61337 Bcl2Family Mitochondria _ Binding 9388232 BAK Q16611 NA Bcl2Family Mitochondria BAD Q92934 Q61337 Bcl2Family Mitochondria _ Binding 9388232 PP2A Q13362 Q80W65 Phosphatase Cytosol CAMKIV Q16566 P08414 Kinase Cytosol _ Dephosphorylation 9596578 PP2A Q13362 Q80W65 Phosphatase Cytosol CAMKIV Q16566 P08414 Kinase Cytosol _ Dephosphorylation 15143065 PAK Q13153 O88643 Kinase Cytosol MLCK Q15746 Q8VDF3 Kinase Cytosol _ Phosphorylation 10092231 GSK3 P49840 Q9WV60 Kinase Cytosol NFAT O95644 O88942 TF Nucleus _ Phosphorylation 11063740 CASK Q9HCP0 Q8BTH8 Kinase Cytosol NFAT O95644 O88942 TF Nucleus _ Phosphorylation 15121840 P38 Q16539 P47811 Kinase Cytosol NFAT O95644 O88942 TF Nucleus _ Phosphorylation 10788511 P38 Q16539 P47811 Kinase Cytosol NFAT O95644 O88942 TF Nucleus _ Phosphorylation 11997522 PKA P17612 P05132 Kinase Cytosol NFAT O95644 O88942 TF Nucleus _ Phosphorylation 10611249 P1433 Q04917 P11576 Adapter Cytosol NFAT O95644 O88942 TF Nucleus _ Binding 10611249 P1433 Q04917 P11576 Adapter Cytosol FORKHEAD Q12778 Q9R1E0 TF Nucleus _ Binding 14690436 FLIP O15519 O35732 Inhibitor Cytosol CASPASE8 Q14790 O89110 Protease Cytosol _ Binding 9217161 SPAL Q96FS4 Q61037 GAP Cytosol PSD95 P78352 Q62108 Adapter Cytosol 0 Binding 12059963 DAP O14490 Q9D415 Adapter Cytosol PSD95 P78352 Q62108 Adapter Cytosol 0 Binding 9286856 SHANK Q9Y566 P31695 Adapter Cytosol HOMER Q9NSB8 Q99JP6 Adapter Cytosol 0 Binding 10433269 MGLUR1 Q13255 P97772 Receptor Membrane HOMER Q9NSB8 Q99JP6 Adapter Cytosol 0 Binding 9808458 RET P09455 Q00915 Receptor Membrane RAI P29353 Q61120 Adapter Cytosol + Binding 12242309 ALPHAACTININ Q08043 O88990 Cytoskeletal Cytosol RABPHILIN Q9Y2J0 P47708 Vesicle Vesicles 0 Binding 8943213 CLIP170 P30622 Q02566 Adapter Cytosol IQGAP P46940 Q9JKF1 GAP Cytosol 0 Binding 12361581 FAK Q05397 Q60750 Kinase Cytosol CAS P56945 Q61140 Adapter Cytosol 0 Binding 8662921 FAK Q05397 Q60750 Kinase Cytosol FYN P06241 P39688 Kinase Cytosol + Binding 10085136 CRK P46108 Q64010 Adapter Cytosol C3G Q13905 P27671 GEF Cytosol + Binding 9591773 SHC P29353 Q61120 Adapter Cytosol GRIT Q8IUG4 Q91V57 GAP Cytosol 0 Binding 12446789 MEKK1 Q13233 P53349 Kinase Cytosol JNK P45983 Q91Y86 Kinase Nucleus + Binding 9405400 PIN1 Q13526 Q9QUR7 TF Nucleus AP1 P05412 P05627 TF Nucleus + Binding 11432833 SV2A Q9BVZ9 Q9Z0E8 Vesicle Vesicles SYNAPTOTAGMIN P21579 P46096 Vesicle Vesicles + Binding 8910372 CALCIUM NA NA Messenger Cytosol SYNAPTOTAGMIN P21579 P46096 Vesicle Vesicles + Binding 7559535 SYNAPTOTAGMIN P21579 P46096 Vesicle Vesicles SYNTAXIN Q13277 O35526 Vesicle Vesicles + Binding 7559535 CAMP NA NA Messenger Cytosol CAMPGEFII Q8WZA2 Q8VCC8 GEF Cytosol + GEF 9856955 PIP2 NA NA Lipid Cytosol NWASP Q92558 P42337 Activator Cytosol + Binding 10444357 PIP2 NA NA Lipid Cytosol NWASP Q92558 P42337 Activator Cytosol + Binding 8895577 PIP2 NA NA Lipid Cytosol NWASP Q92558 P42337 Activator Cytosol + Binding 11052943 CDC42 P60953 P60766 GTPase Cytosol NWASP Q92558 P42337 Activator Cytosol + Binding 11052943 CDC42 P60953 P60766 GTPase Cytosol NWASP Q92558 P42337 Activator Cytosol + Binding 8643625 CDC42 P60953 P60766 GTPase Cytosol NWASP Q92558 P42337 Activator Cytosol + Binding 10360578 GRB2 P62993 Q60631 Adapter Cytosol NWASP Q92558 P42337 Activator Cytosol + Binding 9307968 EGFR P00533 Q01279 Receptor Membrane NWASP Q92558 P42337 Activator Cytosol + Binding 9307968 PP2A Q13362 Q80W65 Phosphatase Cytosol BCL2 P10415 Q64373 Bcl2Family Mitochondria _ Dephosphorylation 9852076 RSK Q15418 P18653 Kinase Cytosol BAD Q92934 Q61337 Bcl2Family Mitochondria _ Phosphorylation 10558990 PKA P17612 P05132 Kinase Cytosol BAD Q92934 Q61337 Bcl2Family Mitochondria _ Phosphorylation 10230394 PKB P31749 Q60823 Kinase Cytosol BAD Q92934 Q61337 Bcl2Family Mitochondria _ Phosphorylation 10383455 CASPASE3 P42574 P70677 Protease Cytosol PP2A Q13362 Q80W65 Phosphatase Cytosol _ Cleavage 9582351 CASPASE3 P42574 P70677 Protease Cytosol CALCINEURIN P06705 P61023 Phosphatase Cytosol + Cleavage 11478781 CASPASE3 P42574 P70677 Protease Cytosol CALCINEURIN P06705 P61023 Phosphatase Cytosol + Cleavage 10898953 SRC P12931 P05480 Kinase Cytosol PLCGAMMA P19174 Q62077 Phospholipase Cytosol + Phosphorylation 8388373 SRC P12931 P05480 Kinase Cytosol PLCGAMMA P19174 Q62077 Phospholipase Cytosol + Phosphorylation 7682059 LCK P06239 P08103 Kinase Cytosol PLCGAMMA P19174 Q62077 Phospholipase Cytosol + Phosphorylation 7682059 LYN P07948 P08103 Kinase Cytosol PLCGAMMA P19174 Q62077 Phospholipase Cytosol + Phosphorylation 7682059 FYN P06241 P39688 Kinase Cytosol PLCGAMMA P19174 Q62077 Phospholipase Cytosol + Phosphorylation 7682059 HCK P08631 P08103 Kinase Cytosol PLCGAMMA P19174 Q62077 Phospholipase Cytosol + Phosphorylation 7682059 ROCK O75116 P70336 Kinase Cytosol CRMP2 Q16555 P47942 Activator Cytosol + Phosphorylation 10818093 LARG Q9NZN5 Q8R4H2 GEF Cytosol RHO Q07960 Q8C0D4 GTPase Cytosol + GEF 11373293 LARG Q9NZN5 Q8R4H2 GEF Cytosol IGF1R P08069 Q60751 Receptor Cytosol 0 Binding 11724822 SODIUM NA NA Ion Cytosol GAT1 P43003 P56564 Transporter Membrane + Binding 7679914 SAP97 Q12959 P70175 Adapter Cytosol N41 P11171 P48193 Adapter Cytosol 0 Binding 7937897 PSD95 P78352 Q62108 Adapter Cytosol LYN P07948 P08103 Kinase Cytosol 0 Binding 14529711 PSD95 P78352 Q62108 Adapter Cytosol YES P07947 P00520 Kinase Cytosol 0 Binding 14529711 PSD95 P78352 Q62108 Adapter Cytosol SRC P12931 P05480 Kinase Cytosol 0 Binding 14529711 AP1 P05412 P05627 TF Nucleus CREB P16220 Q01147 TF Nucleus + Binding 1827203 AP1 P05412 P05627 TF Nucleus CREB P16220 Q01147 TF Nucleus + Binding 8290251 MEKK1 Q13233 P53349 Kinase Cytosol SEK P54764 Q03137 Kinase Cytosol + Phosphorylation 7997270 P38 Q16539 P47811 Kinase Cytosol AP1 P05412 P05627 TF Nucleus + Phosphorylation 12475989 CAMKII Q9UQM7 P11798 Kinase Cytosol SAP97 Q12959 P70175 Adapter Cytosol + Phosphorylation 12933808 GSK3 P49840 Q9WV60 Kinase Cytosol TAU P10636 P20357 Activator Cytosol _ Phosphorylation 8799840 AKAP P24588 Q9JL25 Adapter Cytosol PSD95 P78352 Q62108 Adapter Cytosol 0 Binding 10939335 PDK1 O15530 Q9Z2A0 Kinase Cytosol PKC P17252 P05697 Kinase Cytosol + Phosphorylation 9889098 PLCGAMMA P19174 Q62077 Phospholipase Cytosol SYNAPSIN P17600 O88935 Vesicle Vesicles 0 Binding 10899172 PP2A Q13362 Q80W65 Phosphatase Cytosol CAMKI Q14012 Q91YS8 Kinase Cytosol _ Dephosphorylation 1320022 CAMKII Q9UQM7 P11798 Kinase Cytosol PP2A Q13362 Q80W65 Phosphatase Cytosol _ Dephosphorylation 10646534 SNAP25 P60878 P60881 Vesicle Vesicles CAVEOLIN Q03135 P49817 Adapter Cytosol 0 Binding 11883949 SYNTAXIN Q13277 O35526 Vesicle Vesicles CAVEOLIN Q03135 P49817 Adapter Cytosol 0 Binding 11883949 SRC P12931 P05480 Kinase Cytosol DYNAMIN Q05193 P09922 GTPase Vesicles + Binding 9539797 SYNAPSIN P17600 O88935 Vesicle Vesicles SRC P12931 P05480 Kinase Cytosol 0 Binding 9539797 LRP Q9BQ69 P00755 Receptor Membrane FRIZZLED Q9UP38 O70421 Receptor Membrane + Binding 12857724 ADAPTIN Q10567 O35643 Adapter Cytosol SYNAPTOPHYSIN P08247 Q8BGN8 Vesicle Vesicles 0 Binding 12498786 AMPHIPHYSIN P49418 Q7TQF7 Adapter Cytosol DYNAMIN Q05193 P09922 GTPase Vesicles 0 Binding 11050117 IP6K2 Q9UHH9 Q9Z1B3 Kinase Cytosol GRAB P10144 P04187 GEF Cytosol 0 Binding 11516400 ALPHAACTININ Q08043 O88990 Cytoskeletal Cytosol INTEGRIN P05556 P09055 CellAdhesion Membrane 0 Binding 2116421 PAXILLIN P49023 Q8CI51 Adapter Cytosol FAK Q05397 Q60750 Kinase Cytosol 0 Binding 10764815 CRK P46108 Q64010 Adapter Cytosol PAXILLIN P49023 Q8CI51 Adapter Cytosol 0 Binding 8662907 CRK P46108 Q64010 Adapter Cytosol PAXILLIN P49023 Q8CI51 Adapter Cytosol 0 Binding 10329689 CRK P46108 Q64010 Adapter Cytosol SHC P29353 Q61120 Adapter Cytosol 0 Binding 8662907 CRK P46108 Q64010 Adapter Cytosol CAS P56945 Q61140 Adapter Cytosol 0 Binding 8662907 EGFR P00533 Q01279 Receptor Membrane CRK P46108 Q64010 Adapter Cytosol 0 Binding 8662907 BCL2 P10415 Q64373 Bcl2Family Mitochondria BID P55957 P70444 Bcl2Family Cytosol _ Binding 8918887 BCLXL Q07817 P70345 Bcl2Family Mitochondria BID P55957 P70444 Bcl2Family Cytosol _ Binding 9873064 BCL2 P10415 Q64373 Bcl2Family Mitochondria BIK Q13323 O70337 Bcl2Family Cytosol _ Binding 9305912 BCLXL Q07817 P70345 Bcl2Family Mitochondria BIK Q13323 O70337 Bcl2Family Cytosol _ Binding 9305912 CASPASE8 Q14790 O89110 Protease Cytosol BID P55957 P70444 Bcl2Family Cytosol + Cleavage 9873064 PIP3 NA NA Lipid Cytosol ILK Q13418 O55222 Kinase Cytosol + Binding 9736715 PTEN P60483 O08586 Phosphatase Cytosol PIP3 NA NA Lipid Cytosol _ Dephosphorylation 10716737 GRIT Q8IUG4 Q91V57 GAP Cytosol RHO Q07960 Q8C0D4 GTPase Cytosol _ GAP 12446789 GRIT Q8IUG4 Q91V57 GAP Cytosol CDC42 P60953 P60766 GTPase Cytosol _ GAP 12446789 GRIT Q8IUG4 Q91V57 GAP Cytosol RAC P15154 P15154 GTPase Cytosol _ GAP 12446789 CASPASE3 P42574 P70677 Protease Cytosol DNAPK P78527 P97313 Kinase Nucleus _ Cleavage 8798786 P1433 Q04917 P11576 Adapter Cytosol RAF1 P04049 Q99N57 Kinase Cytosol _ Binding 12801936 CALCINEURIN P06705 P61023 Phosphatase Cytosol I1 Q13522 Q9ERT9 Inhibitor Cytosol _ Dephosphorylation 7515479 CASPASE3 P42574 P70677 Protease Cytosol RB P06400 P13405 TF Nucleus _ Cleavage 10822366 CALCINEURIN P06705 P61023 Phosphatase Cytosol CAMKIV Q16566 P08414 Kinase Cytosol _ Depolymerization 10085155 DAPK P53355 Q8VDF3 Kinase Cytosol SYNTAXIN Q13277 O35526 Vesicle Vesicles _ Phosphorylation 12730201 CASPASE8 Q14790 O89110 Protease Cytosol PKR Q8TCW9 Q9JKL1 Kinase Cytosol _ Cleavage 11555640 CASPASE3 P42574 P70677 Protease Cytosol PKR Q8TCW9 Q9JKL1 Kinase Cytosol _ Cleavage 11555640 CASPASE7 P55210 P97864 Protease Cytosol PKR Q8TCW9 Q9JKL1 Kinase Cytosol _ Cleavage 11555640 CALCINEURIN P06705 P61023 Phosphatase Cytosol NMDAR Q12879 P35436 Receptor Membrane _ Dephosphorylation 7514273 CALCINEURIN P06705 P61023 Phosphatase Cytosol DARPP32 Q9UD71 Q60829 Inhibitor Cytosol _ Dephosphorylation 2153935 SYNAPTOPHYSIN P08247 Q8BGN8 Vesicle Vesicles SYNAPTOBREVIN P23763 Q62442 Vesicle Vesicles 0 Binding 12485399 AMISYN Q8NFX7 Q8R3T5 Vesicle Vesicles SYNTAXIN Q13277 O35526 Vesicle Vesicles _ Binding 12145319 AMISYN Q8NFX7 Q8R3T5 Vesicle Vesicles SNAP25 P60878 P60881 Vesicle Vesicles _ Binding 12145319 CALMODULIN P62158 P62204 Activator Cytosol RYR P21817 Q80X16 Channel ER + Binding 8035880 ADPRIBSYCYCLASE P28907 Q64277 Synthase Cytosol cADPR NA NA Messenger Cytosol + Synthesis 1830494 ADPRIBSYCYCLASE P28907 Q64277 Synthase Cytosol cADPR NA NA Messenger Cytosol + Synthesis 7692303 cADPR NA NA Messenger Cytosol RYR P21817 Q80X16 Channel ER + Binding 8391127 ANANDAMIDE NA NA Ligand Extracellular CB1R P21554 P47746 Receptor Membrane + Binding 15082510 ANANDAMIDE NA NA Ligand Extracellular CB2R P34972 P47936 Receptor Membrane + Binding 15082510 CB1R P21554 P47746 Receptor Membrane GALPHAI P08754 Q9DC51 Gprotein Cytosol + Binding 15082510 CB1R P21554 P47746 Receptor Membrane GALPHAO P09471 P18872 Gprotein Cytosol + Binding 15082510 CB1R P21554 P47746 Receptor Membrane GBETAGAMMA P11016 P11016 Gprotein Cytosol + Binding 15082510 CB2R P34972 P47936 Receptor Membrane GALPHAI P08754 Q9DC51 Gprotein Cytosol + Binding 15082510 CB2R P34972 P47936 Receptor Membrane GALPHAO P09471 P18872 Gprotein Cytosol + Binding 15082510 CB2R P34972 P47936 Receptor Membrane GBETAGAMMA P11016 P11016 Gprotein Cytosol + Binding 15082510 CALCINEURIN P06705 P61023 Phosphatase Cytosol IP3R Q14643 P11881 Channel ER + Dephosphorylation 8521476 FKBP P20071 P26883 Adapter Cytosol CALCINEURIN P06705 P61023 Phosphatase Cytosol + Binding 8521476 FKBP P20071 P26883 Adapter Cytosol CALCINEURIN P06705 P61023 Phosphatase Cytosol + Binding 1715244 FKBP P20071 P26883 Adapter Cytosol CALCINEURIN P06705 P61023 Phosphatase Cytosol + Binding 9356420 FKBP P20071 P26883 Adapter Cytosol CALCINEURIN P06705 P61023 Phosphatase Cytosol + Binding 12514224 FKBP P20071 P26883 Adapter Cytosol IP3R Q14643 P11881 Channel ER 0 Binding 8521476 FKBP P20071 P26883 Adapter Cytosol RYR P21817 Q80X16 Channel ER 0 Binding 8521476 ANKYRIN P16157 Q02357 Cytoskeleton Cytosol IP3R Q14643 P11881 Channel ER 0 Binding 8384211 GLUTAMATE NA NA Ligand Extracellular MGLUR7 Q14831 P35400 Receptor Membrane + Binding 10488094 MGLUR7 Q14831 P35400 Receptor Membrane GALPHAI P08754 Q9DC51 Gprotein Cytosol + Binding 10488094 MGLUR7 Q14831 P35400 Receptor Membrane GALPHAO P09471 P18872 Gprotein Cytosol + Binding 10488094 MGLUR7 Q14831 P35400 Receptor Membrane GBETAGAMMA P11016 P11016 Gprotein Cytosol + Binding 10488094 CALMODULIN P62158 P62204 Activator Cytosol MGLUR7 Q14831 P35400 Receptor Membrane _ Binding 10488094 PKC P17252 P05697 Kinase Cytosol MGLUR7 Q14831 P35400 Receptor Membrane + Phosphorylation 10488094 PKC P17252 P05697 Kinase Cytosol MGLUR7 Q14831 P35400 Receptor Membrane + Phosphorylation 12021391 PKA P17612 P05132 Kinase Cytosol MGLUR7 Q14831 P35400 Receptor Membrane + Phosphorylation 12021391 PKG Q13237 Q9Z0Z0 Kinase Cytosol MGLUR7 Q14831 P35400 Receptor Membrane + Phosphorylation 12021391 CALMODULIN P62158 P62204 Activator Cytosol MGLUR7 Q14831 P35400 Receptor Membrane _ Binding 12021391 MGLUR7 Q14831 P35400 Receptor Membrane GBETAGAMMA P11016 P11016 Gprotein Cytosol + Binding 11395497 CALMODULIN P62158 P62204 Activator Cytosol D2R P14416 P61168 Receptor Membrane _ Binding 10926927 PKC P17252 P05697 Kinase Cytosol PICK1 Q9NRD5 Q62083 Adapter Cytosol 0 Phosphorylation 11007882 PKC P17252 P05697 Kinase Cytosol MGLUR7 Q14831 P35400 Receptor Membrane + Phosphorylation 11007882 PICK1 Q9NRD5 Q62083 Adapter Cytosol MGLUR7 Q14831 P35400 Receptor Membrane _ Binding 10488094 PICK1 Q9NRD5 Q62083 Adapter Cytosol ARF P32889 P32889 GTPase Vesicles 0 Binding 10623590 BETACATENIN P35222 Q02248 TF Cytosol PRESENILIN P49768 P49769 Protease Membrane 0 Binding 9223106 GSK3 P49840 Q9WV60 Kinase Cytosol PRESENILIN P49768 P49769 Protease Membrane _ Phosphorylation 9689133 PRESENILIN P49768 P49769 Protease Membrane TAU P10636 P20357 Activator Cytosol 0 Binding 9689133 GSK3 P49840 Q9WV60 Kinase Cytosol TAU P10636 P20357 Activator Cytosol _ Phosphorylation 9689133 AXIN O15169 O88566 Adapter Cytosol GSK3 P49840 Q9WV60 Kinase Cytosol + Binding 11707456 FRAT2 O75474 Q8K025 Adapter Cytosol GSK3 P49840 Q9WV60 Kinase Cytosol 0 Binding 11707456 FRAT2 O75474 Q8K025 Adapter Cytosol GSK3 P49840 Q9WV60 Kinase Cytosol 0 Binding 15073180 GSK3 P49840 Q9WV60 Kinase Cytosol PRESENILIN P49768 P49769 Protease Membrane _ Phosphorylation 11104755 GSK3 P49840 Q9WV60 Kinase Cytosol TAU P10636 P20357 Activator Cytosol _ Phosphorylation 11007782 PRESENILIN P49768 P49769 Protease Membrane SORCIN P30626 NA Adapter Cytosol 0 Binding 10748169 CALCIUM NA NA Messenger Cytosol SORCIN P30626 NA Adapter Cytosol + Binding 3028774 LTYPECA Q13936 Q13936 Channel Membrane SORCIN P30626 NA Adapter Cytosol 0 Binding 9668070 SORCIN P30626 NA Adapter Cytosol RYR P21817 Q80X16 Channel ER _ Binding 9312152 SORCIN P30626 NA Adapter Cytosol RYR P21817 Q80X16 Channel ER _ Binding 7592856 DOC2 Q14183 Q7TNF0 Vesicle Vesicles MUNC13 O14795 Q9Z1N9 Vesicle Vesicles + Binding 9195900 CALCIUM NA NA Messenger Cytosol DOC2 Q14183 Q7TNF0 Vesicle Vesicles + Binding 9195900 DOC2 Q14183 Q7TNF0 Vesicle Vesicles MUNC13 O14795 Q9Z1N9 Vesicle Vesicles + Binding 9736751 RIM Q86UR5 Q99NE5 Adapter Vesicles CAMPGEFII Q8WZA2 Q8VCC8 GEF Cytosol 0 Binding 11056535 ABP1 P19801 Q8JZQ5 Adapter Cytosol PICCOLO Q9Y6V0 Q9EQZ7 Adapter Cytosol 0 Binding 12654920 ABP1 P19801 Q8JZQ5 Adapter Cytosol DYNAMIN Q05193 P09922 GTPase Vesicles 0 Binding 11309416 NMDAR Q12879 P35436 Receptor Membrane SAP97 Q12959 P70175 Adapter Cytosol 0 Binding 10336672 SAPAP NA NA Adapter Cytosol SSCAM NA NA Adapter Cytosol 0 Binding 9694864 NMDAR Q12879 P35436 Receptor Membrane SSCAM NA NA Adapter Cytosol 0 Binding 9694864 NEUROLIGIN Q8N2Q7 Q99K10 CellAdhesion Membrane SSCAM NA NA Adapter Cytosol 0 Binding 9694864 NMDAR Q12879 P35436 Receptor Membrane MALS NA NA Adapter Cytosol 0 Binding 10341223 PSD95 P78352 Q62108 Adapter Cytosol MALS NA NA Adapter Cytosol 0 Binding 10341223 CIPP NA O70471 Adapter Cytosol NEUREXIN P78357 O54991 CellAdhesion Membrane 0 Binding 9647694 CIPP NA O70471 Adapter Cytosol NEUROLIGIN Q8N2Q7 Q99K10 CellAdhesion Membrane 0 Binding 9647694 CIPP NA O70471 Adapter Cytosol NMDAR Q12879 P35436 Receptor Membrane 0 Binding 9647694 ENDOPHILIN Q99962 Q62420 Vesicle Vesicles DYNAMIN Q05193 P09922 GTPase Vesicles 0 Binding 10490020 CIPP NA O70471 Adapter Cytosol KIR41 P78508 Q9JM63 Channel Membrane 0 Binding 9647694 KIR41 P78508 Q9JM63 Channel Membrane POTASSIUM NA NA Ion Cytosol + Opening 11169792 PSD95 P78352 Q62108 Adapter Cytosol MAP1A P78559 Q9QYR6 Activator Cytosol + Binding 9786987 MLK Q02779 Q60700 Kinase Cytosol PSD95 P78352 Q62108 Adapter Cytosol + Binding 11152698 SRC P12931 P05480 Kinase Cytosol RACK P25388 P25388 Adapter Cytosol 0 Binding 11279199 SRC P12931 P05480 Kinase Cytosol bARK P25098 O70293 Kinase Cytosol + Phosphorylation 11278940 SRC P12931 P05480 Kinase Cytosol MUSK O15146 Q9Z139 Kinase Cytosol + Phosphorylation 11356869 ALPHAACTININ Q08043 O88990 Cytoskeletal Cytosol PLD O14939 P97813 Adapter Cytosol 0 Binding 10801846 PSD95 P78352 Q62108 Adapter Cytosol LTYPECA Q13936 Q13936 Channel Membrane 0 Binding 12850569 CALMODULIN P62158 P62204 Activator Cytosol RIC P15154 P15154 Adapter Cytosol + Binding 9813038 CALMODULIN P62158 P62204 Activator Cytosol RIC P15154 P15154 Adapter Cytosol + Binding 8918462 CALMODULIN P62158 P62204 Activator Cytosol RIN Q99578 P70425 GTPase Cytosol + Binding 8824319 CALMODULIN P62158 P62204 Activator Cytosol RIN Q99578 P70425 GTPase Cytosol + Binding 9813038 CALMODULIN P62158 P62204 Activator Cytosol RIN Q99578 P70425 GTPase Cytosol + Binding 14662747 N41 P11171 P48193 Adapter Cytosol AMPAR P42261 P23818 Channel Membrane + Binding 11050113 SEC61P P61620 P61621 Channel ER NASCENTCHAIN NA NA Peptide Ribosomes 0 Binding 12887911 S40 NA NA Ribosome Ribosomes SEC61P P61620 P61621 Channel ER 0 Binding 11036067 S60 NA NA Ribosome Ribosomes SEC61P P61620 P61621 Channel ER 0 Binding 11036067 IP3R Q14643 P11881 Channel ER HOMER Q9NSB8 Q99JP6 Adapter Cytosol 0 Binding 9808459 HOMER Q9NSB8 Q99JP6 Adapter Cytosol AMPAR P42261 P23818 Channel Membrane 0 Binding 9808459 CALCINEURIN P06705 P61023 Phosphatase Cytosol LTYPECA Q13936 Q13936 Channel Membrane _ Dephosphorylation 11124974 IP3R Q14643 P11881 Channel ER CALCIUM NA NA Messenger Cytosol + Opening 2847175 IP3R Q14643 P11881 Channel ER CALCIUM NA NA Messenger Cytosol + Opening 3027583 PQCaCh O00555 P97445 Channel Membrane CALCIUM NA NA Messenger Cytosol + Opening 1651493 PQCaCh O00555 P97445 Channel Membrane CALCIUM NA NA Messenger Cytosol + Opening 10321243 LTYPECA Q13936 Q13936 Channel Membrane CALCIUM NA NA Messenger Cytosol + Opening 2449181 LTYPECA Q13936 Q13936 Channel Membrane CALCIUM NA NA Messenger Cytosol + Opening 1188153 NTYPECA Q00975 P97445 Channel Membrane CALCIUM NA NA Messenger Cytosol + Opening 1334419 NTYPECA Q00975 P97445 Channel Membrane CALCIUM NA NA Messenger Cytosol + Opening 8386525 SRC P12931 P05480 Kinase Cytosol SYK P43405 Q01279 Kinase Cytosol + Phosphorylation 7513017 LYN P07948 P08103 Kinase Cytosol SYK P43405 Q01279 Kinase Cytosol 0 Binding 7831290 SYK P43405 Q01279 Kinase Cytosol PLCGAMMA P19174 Q62077 Phospholipase Cytosol + Phosphorylation 7744830 SYK P43405 Q01279 Kinase Cytosol PLCGAMMA P19174 Q62077 Phospholipase Cytosol + Phosphorylation 8657103 NEUROFIBROMIN P21359 Q04690 GAP Cytosol RAS P01111 P08556 GTPase Cytosol _ Binding 2116237 NEUROFIBROMIN P21359 Q04690 GAP Cytosol RAS P01111 P08556 GTPase Cytosol _ Binding 2121370 DOPAMINE NA NA Ligand Extracellular D3R P35462 P30728 Receptor Membrane + Binding 15102843 D3R P35462 P30728 Receptor Membrane GALPHAI P08754 Q9DC51 Gprotein Cytosol + Binding 15102843 D3R P35462 P30728 Receptor Membrane GALPHAO P09471 P18872 Gprotein Cytosol + Binding 15102843 D3R P35462 P30728 Receptor Membrane GBETAGAMMA P11016 P11016 Gprotein Cytosol + Binding 15102843 D3R P35462 P30728 Receptor Membrane GRB2 P62993 Q60631 Adapter Cytosol + Binding 11384839 CAMKII Q9UQM7 P11798 Kinase Cytosol SYNAPTOTAGMIN P21579 P46096 Vesicle Vesicles + Phosphorylation 9016342 MAPK P28482 P27703 Kinase Cytosol SAM68 Q8TCZ4 Q64213 Adapter Cytosol + Phosphorylation 12478298 SRC P12931 P05480 Kinase Cytosol LTYPECA Q13936 Q13936 Channel Membrane + Phosphorylation 12850569 FYN P06241 P39688 Kinase Cytosol LTYPECA Q13936 Q13936 Channel Membrane + Phosphorylation 12850569 PSD95 P78352 Q62108 Adapter Cytosol KV12 P16389 P15386 Channel Membrane 0 Binding 7477295 NOS P29475 Q9Z0J4 Synthase Cytosol PSD93 Q15700 P70175 Adapter Cytosol 0 Binding 8922396 NMDAR Q12879 P35436 Receptor Membrane PSD93 Q15700 P70175 Adapter Cytosol 0 Binding 8922396 NMDAR Q12879 P35436 Receptor Membrane PSD95 P78352 Q62108 Adapter Cytosol 0 Binding 8922396 PSD95 P78352 Q62108 Adapter Cytosol NOS P29475 Q9Z0J4 Synthase Cytosol 0 Binding 8922396 PKA P17612 P05132 Kinase Cytosol KIR23 P48050 P52189 Channel Membrane _ Phosphorylation 8893032 KIR21 P48049 P35561 Channel Membrane POTASSIUM NA NA Ion Cytosol + Opening 8893032 PSD95 P78352 Q62108 Adapter Cytosol KIR21 P48049 P35561 Channel Membrane 0 Binding 8893032 KIR23 P48050 P52189 Channel Membrane POTASSIUM NA NA Ion Cytosol + Opening 8893032 PSD95 P78352 Q62108 Adapter Cytosol KIR23 P48050 P52189 Channel Membrane 0 Binding 8893032 PSD95 P78352 Q62108 Adapter Cytosol CHAPSYN110 Q15700 Q63622 Adapter Cytosol 0 Binding 8755482 NMDAR Q12879 P35436 Receptor Membrane CHAPSYN110 Q15700 Q63622 Adapter Cytosol 0 Binding 8755482 KIR21 P48049 P35561 Channel Membrane CHAPSYN110 Q15700 Q63622 Adapter Cytosol 0 Binding 8755482 KIR21 P48049 P35561 Channel Membrane CHAPSYN110 Q15700 Q63622 Adapter Cytosol 0 Binding 15304517 FYN P06241 P39688 Kinase Cytosol PSD93 Q15700 P70175 Adapter Cytosol 0 Phosphorylation 13129934 FYN P06241 P39688 Kinase Cytosol NMDAR Q12879 P35436 Receptor Membrane + Phosphorylation 9892651 PSD95 P78352 Q62108 Adapter Cytosol FYN P06241 P39688 Kinase Cytosol 0 Binding 9892651 ERBB P04626 Q01279 Receptor Membrane PSD95 P78352 Q62108 Adapter Cytosol 0 Binding 10839362 ERBB P04626 Q01279 Receptor Membrane PSD95 P78352 Q62108 Adapter Cytosol 0 Binding 11279080 ERBB P04626 Q01279 Receptor Membrane ERBIN Q96RT1 Q80TH2 Adapter Cytosol 0 Binding 11279080 PSD95 P78352 Q62108 Adapter Cytosol ERBIN Q96RT1 Q80TH2 Adapter Cytosol 0 Binding 11279080 ANKYRIN P16157 Q02357 Cytoskeleton Cytosol SPECTRIN O15020 Q62261 Cytoskeleton Cytosol 0 Binding 11086001 ANKYRIN P16157 Q02357 Cytoskeleton Cytosol SPECTRIN O15020 Q62261 Cytoskeleton Cytosol 0 Binding 7621818 NRG Q99988 Q9Z0J7 Ligand Extracellular ERBB P04626 Q01279 Receptor Membrane + Binding 6328316 PKA P17612 P05132 Kinase Cytosol LTYPECA Q13936 Q13936 Channel Membrane _ Phosphorylation 7621818 SEC63P Q9UGP8 Q9QYI4 Adapter ER SEC61P P61620 P61621 Channel ER + Binding 10799540 PIP2 NA NA Lipid Cytosol RYR P21817 Q80X16 Channel ER + Binding 1850418 CLATHRIN P09496 O08585 Vesicle Vesicles CALMODULIN P62158 P62204 Activator Cytosol 0 Binding 7836475 SYNTAXIN Q13277 O35526 Vesicle Vesicles PQCaCh O00555 P97445 Channel Membrane 0 Binding 8524397 SYNTAXIN Q13277 O35526 Vesicle Vesicles NTYPECA Q00975 P97445 Channel Membrane _ Binding 8524397 PKA P17612 P05132 Kinase Cytosol PQCaCh O00555 P97445 Channel Membrane _ Phosphorylation 12410316 BIP P11021 P08109 Chaperone ER SEC61P P61620 P61621 Channel ER + Binding 1568250 BAG1 O95816 Q8BR07 Adapter Cytosol RAF1 P04049 Q99N57 Kinase Cytosol + Binding 12502846 BAG1 O95816 Q8BR07 Adapter Cytosol RAF1 P04049 Q99N57 Kinase Cytosol + Binding 14978028 BAG1 O95816 Q8BR07 Adapter Cytosol RAF1 P04049 Q99N57 Kinase Cytosol + Binding 8692945 BAG1 O95816 Q8BR07 Adapter Cytosol BCL2 P10415 Q64373 Bcl2Family Mitochondria + Binding 8692945 BAG1 O95816 Q8BR07 Adapter Cytosol BCL2 P10415 Q64373 Bcl2Family Mitochondria + Binding 7834747 KAR P39086 Q60934 Channel Membrane NCADHERIN P19022 P39038 CellAdhesion Membrane 0 Binding 12151522 MDM2 Q00987 O35618 Ubiquitinase Nucleus P53 Q12888 P70399 TF Nucleus _ Ubiquitination 14671306 PIP3 NA NA Lipid Cytosol PKC P17252 P05697 Kinase Cytosol + Binding 8395820 GKAP O14490 P97836 Adapter Cytosol NOS P29475 Q9Z0J4 Synthase Cytosol + Binding 11122378 CALCIUM NA NA Messenger Cytosol VILIP P28677 P28677 Adapter Cytosol + Binding 1359372 CALCIUM NA NA Messenger Cytosol VILIP P28677 P28677 Adapter Cytosol + Binding 7806504 CALCIUM NA NA Messenger Cytosol NCS1 P62166 Q8BNY6 Adapter Cytosol + Binding 7806504 PKC P17252 P05697 Kinase Cytosol RAF1 P04049 Q99N57 Kinase Cytosol + Phosphorylation 9447975 PKC P17252 P05697 Kinase Cytosol RAF1 P04049 Q99N57 Kinase Cytosol + Phosphorylation 1437148 CALPAIN P07384 O35350 Protease Cytosol NMDAR Q12879 P35436 Receptor Membrane _ Cleavage 11553682 PKA P17612 P05132 Kinase Cytosol MST3 Q9Y6E0 Q9Z2W1 Adapter Cytosol + Phosphorylation 10644707 CREB P16220 Q01147 TF Nucleus CBP Q92793 P45481 TF Nucleus + Binding 8413673 EGFR P00533 Q01279 Receptor Membrane SHC P29353 Q61120 Adapter Cytosol + Binding 7681824 INTEGRIN P05556 P09055 CellAdhesion Membrane PYK2 Q14289 Q60629 Kinase Cytosol + Binding 9022036 INTEGRIN P05556 P09055 CellAdhesion Membrane PYK2 Q14289 Q60629 Kinase Cytosol + Binding 9366396 CALCINEURIN P06705 P61023 Phosphatase Cytosol BAD Q92934 Q61337 Bcl2Family Mitochondria + Dephosphorylation 10195903 P1433 Q04917 P11576 Adapter Cytosol P53 Q12888 P70399 TF Nucleus + Binding 9620776 CDK5 Q00535 P49615 Kinase Cytosol TAU P10636 P20357 Activator Cytosol + Phosphorylation 8282104 CDK5 Q00535 P49615 Kinase Cytosol TAU P10636 P20357 Activator Cytosol + Phosphorylation 7592534 IR P06213 P15208 Receptor Membrane IRS2 Q9Y4H2 O08648 Adapter Cytosol + Phosphorylation 7526222 IR P06213 P15208 Receptor Membrane IRS2 Q9Y4H2 O08648 Adapter Cytosol + Phosphorylation 7675087 IR P06213 P15208 Receptor Membrane IRS2 Q9Y4H2 O08648 Adapter Cytosol + Phosphorylation 9195949 TRKB Q16620 Q9Z139 Receptor Membrane IRS2 Q9Y4H2 O08648 Adapter Cytosol + Phosphorylation 9374521 IRS2 Q9Y4H2 O08648 Adapter Cytosol PI3K P42336 P42337 Kinase Cytosol + Binding 9374521 IRS1 P35568 P35569 Adapter Cytosol PI3K P42336 P42337 Kinase Cytosol + Binding 9374521 TRKB Q16620 Q9Z139 Receptor Membrane IRS1 P35568 P35569 Adapter Cytosol + Binding 9374521 P1433 Q04917 P11576 Adapter Cytosol IRS1 P35568 P35569 Adapter Cytosol _ Binding 9312143 MAPK P28482 P27703 Kinase Cytosol MEF2 Q02080 O55087 TF Nucleus + Phosphorylation 9069290 MAPK P28482 P27703 Kinase Cytosol MEF2 Q02080 O55087 TF Nucleus + Phosphorylation 9384584 PKC P17252 P05697 Kinase Cytosol PICK1 Q9NRD5 Q62083 Adapter Cytosol 0 Phosphorylation 9405395 PKC P17252 P05697 Kinase Cytosol PICK1 Q9NRD5 Q62083 Adapter Cytosol 0 Phosphorylation 7844141 CALPAIN P07384 O35350 Protease Cytosol CAIN Q9Y6J0 P11627 Inhibitor Cytosol _ Cleavage 12114545 CAIN Q9Y6J0 P11627 Inhibitor Cytosol CALCINEURIN P06705 P61023 Phosphatase Cytosol _ Binding 9660798 MAPK P28482 P27703 Kinase Cytosol MARCKS P29966 P26645 Adapter Cytosol + Phosphorylation 9867858 CALCIUM NA NA Messenger Cytosol DREAM Q9Y2W7 Q9QXT8 TF Nucleus + Binding 11535596 DGK Q16854 Q9QX60 Kinase Cytosol DAG NA NA Lipid Cytosol _ Phosphorylation 11287665 PLCGAMMA P19174 Q62077 Phospholipase Cytosol PIP2 NA NA Lipid Cytosol _ Cleavage 2472219 EGFR P00533 Q01279 Receptor Membrane PLCGAMMA P19174 Q62077 Phospholipase Cytosol + Phosphorylation 2472219 PDGFR P09619 P05622 Receptor Membrane PLCGAMMA P19174 Q62077 Phospholipase Cytosol + Phosphorylation 2472219 PKA P17612 P05132 Kinase Cytosol GABAAR P14867 P18504 Receptor Membrane _ Phosphorylation 2176510 PKA P17612 P05132 Kinase Cytosol GABAAR P14867 P18504 Receptor Membrane _ Phosphorylation 1321150 PKA P17612 P05132 Kinase Cytosol GABAAR P14867 P18504 Receptor Membrane _ Phosphorylation 1323140 CALCINEURIN P06705 P61023 Phosphatase Cytosol CREB P16220 Q01147 TF Nucleus _ Dephosphorylation 14697672 N41 P11171 P48193 Adapter Cytosol SPECTRIN O15020 Q62261 Cytoskeleton Cytosol 0 Binding 3121803 GRB2 P62993 Q60631 Adapter Cytosol SHP1 Q96B97 Q9JLQ0 Phosphatase Cytosol 0 Binding 14551136 CSP Q9H3Z4 P60904 Adapter Cytosol PQCaCh O00555 P97445 Channel Membrane 0 Binding 9593683 CSP Q9H3Z4 P60904 Adapter Cytosol NTYPECA Q00975 P97445 Channel Membrane _ Binding 11086994 CSP Q9H3Z4 P60904 Adapter Cytosol GBETAGAMMA P11016 P11016 Gprotein Cytosol + Binding 11086994 GBETAGAMMA P11016 P11016 Gprotein Cytosol NTYPECA Q00975 P97445 Channel Membrane _ Binding 11086994 SYNTAXIN Q13277 O35526 Vesicle Vesicles NTYPECA Q00975 P97445 Channel Membrane _ Binding 10844004 SYNTAXIN Q13277 O35526 Vesicle Vesicles PQCaCh O00555 P97445 Channel Membrane 0 Binding 9593683 SNAP25 P60878 P60881 Vesicle Vesicles PQCaCh O00555 P97445 Channel Membrane 0 Binding 9593683 SYNAPTOTAGMIN P21579 P46096 Vesicle Vesicles PQCaCh O00555 P97445 Channel Membrane 0 Binding 9593683 CREB P16220 Q01147 TF Nucleus TFIIB Q00403 P29053 TF Nucleus + Binding 7615553 SHC P29353 Q61120 Adapter Cytosol PI3K P42336 P42337 Kinase Cytosol + Binding 7537361 ERBB P04626 Q01279 Receptor Membrane SHC P29353 Q61120 Adapter Cytosol + Binding 8026468 ERBB P04626 Q01279 Receptor Membrane PI3K P42336 P42337 Kinase Cytosol + Binding 8026468 TRKA P04629 Q9Z139 Receptor Membrane PI3K P42336 P42337 Kinase Cytosol + Binding 8226808 PKA P17612 P05132 Kinase Cytosol RIM Q86UR5 Q99NE5 Adapter Vesicles + Phosphorylation 14532002 ADAPTIN Q10567 O35643 Adapter Cytosol GABAAR P14867 P18504 Receptor Membrane _ Binding 11050117 ADAPTIN Q10567 O35643 Adapter Cytosol CLATHRIN P09496 O08585 Vesicle Vesicles + Binding 11050117 ADAPTIN Q10567 O35643 Adapter Cytosol CLATHRIN P09496 O08585 Vesicle Vesicles + Binding 8909539 ADAPTIN Q10567 O35643 Adapter Cytosol DYNAMIN Q05193 P09922 GTPase Vesicles + Binding 11050117 ADAPTIN Q10567 O35643 Adapter Cytosol DYNAMIN Q05193 P09922 GTPase Vesicles + Binding 10398591 RHO Q07960 Q8C0D4 GTPase Cytosol PIP5K P48426 Q80XI4 Kinase Cytosol + Binding 8868471 PIP5K P48426 Q80XI4 Kinase Cytosol PIP2 NA NA Lipid Cytosol + Phosphorylation 7852364 CERAMIDE NA NA Lipid Cytosol PP2A Q13362 Q80W65 Phosphatase Cytosol + Binding 10400653 CERAMIDE NA NA Lipid Cytosol PP1 P36873 P37139 Phosphatase Cytosol + Binding 10400653 PA NA NA Messenger Cytosol PP1 P36873 P37139 Phosphatase Cytosol _ Binding 10409693 CERAMIDE NA NA Lipid Cytosol PP2A Q13362 Q80W65 Phosphatase Cytosol + Binding 8393446 PRMT1 Q99873 Q9JIF0 Methylase Cytosol SAM68 Q8TCZ4 Q64213 Adapter Cytosol + Methylation 12529443 GRAB P10144 P04187 GEF Cytosol RAB3 P20336 P05713 GTPase Vesicles + GEF 11516400 COLLAGEN P02452 P08121 Matrix Extracellular INTEGRIN P05556 P09055 CellAdhesion Membrane + Binding 7716514 VITRONECTIN P04004 P29788 Matrix Extracellular INTEGRIN P05556 P09055 CellAdhesion Membrane + Binding 7716514 FIBRINOGEN P02671 Q9R045 Ligand Extracellular INTEGRIN P05556 P09055 CellAdhesion Membrane + Binding 7716514 C3G Q13905 P27671 GEF Cytosol RAS P01111 P08556 GTPase Cytosol + GEF 7959692 ENKEPHALIN P01210 P22005 Ligand Extracellular DOPR P41143 P32300 Receptor Membrane + Binding 15082510 ENKEPHALIN P01210 P22005 Ligand Extracellular KOPR P41145 P33534 Receptor Membrane + Binding 15082510 ENKEPHALIN P01210 P22005 Ligand Extracellular MOPR P35372 P42866 Receptor Membrane + Binding 15082510 ENKEPHALIN P01210 P22005 Ligand Extracellular NOPR P41146 P35377 Receptor Membrane + Binding 15082510 DOPR P41143 P32300 Receptor Membrane GBETAGAMMA P11016 P11016 Gprotein Cytosol + Binding 15082510 KOPR P41145 P33534 Receptor Membrane GBETAGAMMA P11016 P11016 Gprotein Cytosol + Binding 15082510 MOPR P35372 P42866 Receptor Membrane GBETAGAMMA P11016 P11016 Gprotein Cytosol + Binding 15082510 NOPR P41146 P35377 Receptor Membrane GBETAGAMMA P11016 P11016 Gprotein Cytosol + Binding 15082510 DOPR P41143 P32300 Receptor Membrane GALPHAO P09471 P18872 Gprotein Cytosol + Binding 15082510 DOPR P41143 P32300 Receptor Membrane GALPHAI P08754 Q9DC51 Gprotein Cytosol + Binding 15082510 KOPR P41145 P33534 Receptor Membrane GALPHAO P09471 P18872 Gprotein Cytosol + Binding 15082510 KOPR P41145 P33534 Receptor Membrane GALPHAI P08754 Q9DC51 Gprotein Cytosol + Binding 15082510 MOPR P35372 P42866 Receptor Membrane GALPHAO P09471 P18872 Gprotein Cytosol + Binding 15082510 MOPR P35372 P42866 Receptor Membrane GALPHAI P08754 Q9DC51 Gprotein Cytosol + Binding 15082510 NOPR P41146 P35377 Receptor Membrane GALPHAO P09471 P18872 Gprotein Cytosol + Binding 15082510 NOPR P41146 P35377 Receptor Membrane GALPHAI P08754 Q9DC51 Gprotein Cytosol + Binding 15082510 ERBB P04626 Q01279 Receptor Membrane SYNTROPHIN Q13424 Q61234 Adapter Cytosol + Binding 10725395 ERBB P04626 Q01279 Receptor Membrane PSD95 P78352 Q62108 Adapter Cytosol 0 Binding 10725395 ERBB P04626 Q01279 Receptor Membrane PSD93 Q15700 P70175 Adapter Cytosol 0 Binding 10725395 ERBB P04626 Q01279 Receptor Membrane SAP102 Q92796 P70175 Adapter Cytosol 0 Binding 10725395 NMDAR Q12879 P35436 Receptor Membrane PLCGAMMA P19174 Q62077 Phospholipase Cytosol + Binding 9231720 NMDAR Q12879 P35436 Receptor Membrane PTP1D NA NA Phosphatase Cytosol 0 Binding 10381539 NT4 NA NA Ligand Extracellular TRKB Q16620 Q9Z139 Receptor Membrane + Binding 9354329 NT4 NA NA Ligand Extracellular TRKB Q16620 Q9Z139 Receptor Membrane + Binding 8264643 NT4 NA NA Ligand Extracellular TRKB Q16620 Q9Z139 Receptor Membrane + Binding 9728914 CAMKII Q9UQM7 P11798 Kinase Cytosol SAP97 Q12959 P70175 Adapter Cytosol + Phosphorylation 15044483 NMDAR Q12879 P35436 Receptor Membrane SAP102 Q92796 P70175 Adapter Cytosol + Binding 11937501 NMDAR Q12879 P35436 Receptor Membrane PSD95 P78352 Q62108 Adapter Cytosol 0 Binding 11937501 TRKA P04629 Q9Z139 Receptor Membrane IRS1 P35568 P35569 Adapter Cytosol + Phosphorylation 11147812 TRKA P04629 Q9Z139 Receptor Membrane SHC P29353 Q61120 Adapter Cytosol + Binding 9715270 RAP2 P10114 Q8BU31 GTPase Cytosol RAS P01111 P08556 GTPase Cytosol + Binding 10085114 RAP2 P10114 Q8BU31 GTPase Cytosol RALGDS Q12967 Q03385 GEF Cytosol + Binding 10085114 IGF1R P08069 Q60751 Receptor Cytosol IRS1 P35568 P35569 Adapter Cytosol + Binding 8776723 IGF1R P08069 Q60751 Receptor Cytosol SHC P29353 Q61120 Adapter Cytosol + Binding 8776723 IGF1R P08069 Q60751 Receptor Cytosol GRB10 Q13322 Q60760 Adapter Cytosol + Binding 8776723 FAK Q05397 Q60750 Kinase Cytosol ALPHAACTININ Q08043 O88990 Cytoskeletal Cytosol _ Phosphorylation 15070900 IR P06213 P15208 Receptor Membrane GRB10 Q13322 Q60760 Adapter Cytosol + Binding 12783867 GRB10 Q13322 Q60760 Adapter Cytosol PI3K P42336 P42337 Kinase Cytosol + Binding 12783867 CALCINEURIN P06705 P61023 Phosphatase Cytosol GABAAR P14867 P18504 Receptor Membrane + Dephosphorylation 12574411 RALBP1 Q15311 Q62172 GAP Cytosol CDC42 P60953 P60766 GTPase Cytosol _ GAP 7623849 RAL P11233 P05810 GTPase Cytosol RALBP1 Q15311 Q62172 GAP Cytosol + Binding 7623849 RALBP1 Q15311 Q62172 GAP Cytosol RAC P15154 P15154 GTPase Cytosol _ GAP 9395447 RALBP1 Q15311 Q62172 GAP Cytosol REPS1 Q96D71 O54916 Adapter Cytosol 0 Binding 9395447 REPS1 Q96D71 O54916 Adapter Cytosol CRK P46108 Q64010 Adapter Cytosol 0 Binding 9395447 REPS1 Q96D71 O54916 Adapter Cytosol GRB2 P62993 Q60631 Adapter Cytosol 0 Binding 9395447 CALCINEURIN P06705 P61023 Phosphatase Cytosol CREB P16220 Q01147 TF Nucleus _ Dephosphorylation 8195196 PP1 P36873 P37139 Phosphatase Cytosol CREB P16220 Q01147 TF Nucleus _ Dephosphorylation 8195196 PP2A Q13362 Q80W65 Phosphatase Cytosol CREB P16220 Q01147 TF Nucleus _ Dephosphorylation 8195196 CEK1 Q8TCT0 Q8K4Q7 Kinase Cytosol RAF1 P04049 Q99N57 Kinase Cytosol + Phosphorylation 7477354 CERAMIDE NA NA Lipid Cytosol CEK1 Q8TCT0 Q8K4Q7 Kinase Cytosol + Binding 7477354 CERAMIDE NA NA Lipid Cytosol PKC P17252 P05697 Kinase Cytosol + Binding 9772184 CERAMIDE NA NA Lipid Cytosol PKC P17252 P05697 Kinase Cytosol + Binding 15189345 MGLUR1 Q13255 P97772 Receptor Membrane TAMALIN NA Q8R4T5 Adapter Cytosol + Binding 11850456 TAMALIN NA Q8R4T5 Adapter Cytosol PSD95 P78352 Q62108 Adapter Cytosol 0 Binding 12586822 MGLUR1 Q13255 P97772 Receptor Membrane TAMALIN NA Q8R4T5 Adapter Cytosol + Binding 15173175 TAMALIN NA Q8R4T5 Adapter Cytosol SYK P43405 Q01279 Kinase Cytosol + Binding 15173175